2CKN


Conserved Protein Domain Family
IgI_1_FGFR

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cd04973: IgI_1_FGFR 
First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the first immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for all FGFs.
Statistics
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PSSM-Id: 409362
View PSSM: cd04973
Aligned: 6 rows
Threshold Bit Score: 172.771
Threshold Setting Gi: 109157343
Created: 18-Sep-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ####                                                                            
2CKN_A      1 PTLPeqaqpw-gvpveVESLLVHPGDLLQLRCRLRDdvqSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVT 79  house mouse
120048     25 STLPdevap--ktkteVEPYSAQPGDRITLQCRLREdvqSINWVKNGVQLSETNRTRITGEEIQISNAGPEDNGVYACVT 102 African clawed frog
P21804     25 PTLPdqalp--kanieVESHSAHPGDLLQLRCRLRDdvqSINWVRDGVQLPENNRTRITGEEVEVRDAVPEDSGLYACMT 102 chicken
P21802     31 TTLEpeepptkyqisqPEVYVAAPGESLEVRCLLKDa-aVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTA 109 human
P18461     34 ATLEpeepptkyqisqPDVHSALPGEPLELRCQLKDa-vMISWTKDGVPLGPDNRTVIIGEYLQIKDASPRDSGLYACTA 112 chicken
AAA35835   25 PTLPeqaqpw-gapveVESFLVHPGDLLQLRCRLRDdvqSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVT 103 human
Feature 1                    
2CKN_A     80 SSPSGSDTTYFSVNV 94  house mouse
120048    103 NGPSRTYTVLCSVNV 117 African clawed frog
P21804    103 NSPSGSETTYFSVNV 117 chicken
P21802    110 SRTVDSETWYFMVNV 124 human
P18461    113 IRTLDSDTLYFIVNV 127 chicken
AAA35835  104 SSPSGSDTTYFSVNV 118 human

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