1HCF,1WWC,1HE7,2IFG


Conserved Protein Domain Family
IgI_TrKABC_d5

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cd04971: IgI_TrKABC_d5 
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the fifth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrkB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system. This group belongs to the I-set of IgSF domains.
Statistics
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PSSM-Id: 409360
View PSSM: cd04971
Aligned: 10 rows
Threshold Bit Score: 147.165
Threshold Setting Gi: 5822441
Created: 12-Feb-2007
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:
  • Structure:1HCF; human Trkb domain 5 bound to neurotrophin-45, a nerve growth factor, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #                   ##
1HCF_X      4 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNEsk---------yICTKIHVtn------htEYHGCLQLDN 68  human
1WWC_A      8 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLREsk---------iIHVEYYQeg-------eISEGCLLFNK 71  human
1HE7_A      3 MPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNEts---------fIFTEFLEpaa----netVRHGCLRLNQ 69  human
2IFG_A    249 FPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNEts---------fIFTEFLEpaa----netVRHGCLRLNQ 315 human
AAH87462  283 PPVITFIDLPTLDHHWCIPFSVRGNPKPTLQWFHEGNVLSEtd---------fIWSKIHEtsn----ntiEHHGCLQLDS 349 African clawed frog
CAG03100  190 PPVILRLAEPEQRHDTCIEFTVRGYPHPKLRWFHEHKEIQQnd---------yIRTEMDYyq-------dYLEGCLTFQN 253 Tetraodon nigrovir...
AAX94284  283 APPRILSLEYKVLFHKSICFTVHGYPLPTLTWYKGRALFTArn---------hMYVSMENskv----tpyETSGCLKFEV 349 Florida lancelet
XP_793428 335 APKINRFWGPIKRFHYCIDLNVTALPTPNVTIYHNGTKELHydarldnvtinsHPTMRRYevttkartpwQIFGCLMFLL 414 purple urchin
NP_990562 285 APNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEGAILNEse---------yICTKIHVin------qsEYHGCLQLDN 349 chicken
CAM56611  336 PPTVLELYLPERSQDWCIPFVVTGNPRPDLHWYHEGKPLEEqe---------yIRTEIHDit------ntEYHGCLKLDT 400 zebrafish
Feature 1       #                          
1HCF_X     69 PTHMNNGDYTLIAKNEYGKDEKQISAHFM 97  human
1WWC_A     72 PTHYNNGNYTLIAKNPLGTANQTINGHFL 100 human
1HE7_A     70 PTHVNNGNYTLLAANPFGQASASIMAAFM 98  human
2IFG_A    316 PTHVNNGNYTLLAANPFGQASASIMAAFM 344 human
AAH87462  350 PTHLNNGFYTLRAENKYGRDERSISALFM 378 African clawed frog
CAG03100  254 PTHINNGNYTLEASNALGTVTKTVFGHFL 282 Tetraodon nigroviridis
AAX94284  350 PSHVDNGNYTLVATNTYGQTSRSLVVTFM 378 Florida lancelet
XP_793428 415 PSHYDNGNYTLVVSNELGSDRKNISAIFF 443 purple urchin
NP_990562 350 PTHLNNGAYTLLAKNEYGEDEKRVDAHFM 378 chicken
CAM56611  401 PTHIHNGIYTLVASNEFGEDRGNVTAHFM 429 zebrafish

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