Conserved Protein Domain Family
ACT_AKi-DapG-BS_2

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cd04937: ACT_AKi-DapG-BS_2 
ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI
This CD includes the C-terminal of the two ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI, a monofunctional class enzyme found in Bacilli (Bacillus subtilis (BS) strain 168), Clostridia, and Actinobacteria bacterial species. In B. subtilis, the regulation of the diaminopimelate-lysine biosynthetic pathway involves dual control by diaminopimelate and lysine, effected through separate diaminopimelate- and lysine-sensitive AK isoenzymes. AKI activity is invariant during the exponential and stationary phases of growth and is not altered by addition of amino acids to the growth medium. The role of this isoenzyme is most likely to provide a constant level of aspartyl-beta-phosphate for the biosynthesis of diaminopimelate for peptidoglycan synthesis and dipicolinate during sporulation. The BS AKI is tetrameric consisting of two alpha and two beta subunits; the alpha (43 kD) and beta (17 kD) subunit formed by two in-phase overlapping genes. The alpha subunit contains the AK catalytic domain and two ACT domains. The beta subunit contains two ACT domains. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153209
View PSSM: cd04937
Aligned: 8 rows
Threshold Bit Score: 107.093
Threshold Setting Gi: 126698921
Created: 19-Apr-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q04795       339 CAKVSAVGAGIMGv-PGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPAVNALHEEFEL 402 Bacillus subtilis
NP_623000    335 CAKVSIIGNRIRGv-PGVMARVIKALSKRNIEIYQTADSHNTISCLVSQDKVEEAIRVLHDEFSL 398 Thermoanaerobacter tengcongens...
YP_075377    340 CAKVTVVGSGMRGr-PGVMATVAEALYAAEVPIWQTADSHVTISCLIPAADVQRAVQALHDAFEL 403 Symbiobacterium thermophilum I...
BAB81384     335 LSTIAIVGSRMRGi-PGVMAKIVGALDNENIEVLQTADSHMTIWCLVESKNVREAIKALHRVFMK 398 Clostridium perfringens str. 13
AAK79775     333 CSKIAIIGNRICGv-PGVMAKILKAITKEGIEVLQTADSHTTIWCLVKSNVRNKAINALHREFNL 396 Clostridium acetobutylicum ATC...
ZP_00801907  341 CSKVTVVGNRITGi-PGVMATIVGALSSEDIQILQSSDSHSTISCLVDESDAKKAVNALHSAFHL 404 Alkaliphilus metalliredigenes ...
YP_535949    334 CVKVSIIGGGMVGt-PGVIAKMVTALSKTGVEILQTADSDTTVWILVTEDNFKLAVNTLHEAFLE 397 Lactobacillus salivarius subsp...
YP_001087818 342 CAKVTLICSRIADemSGIMSKVVRGLSKAGVSLLQTSDSNMTISCLVSEEDMHTAVHAIHQQFYL 406 Clostridium difficile 630
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