Conserved Protein Domain Family
ACT_TH
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cd04930: ACT_TH 
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH). TH catalyses the hydroxylation of L-Tyr to 3,4-dihydroxyphenylalanine, the rate limiting step in the biosynthesis of catecholamines (dopamine, noradrenaline and adrenaline), functioning as hormones and neurotransmitters. The enzyme is not regulated by its amino acid substrate, but instead by phosphorylation at several serine residues located N-terminal of the ACT domain, and by feedback inhibition by catecholamines at the active site. Members of this CD belong to the superfamily of ACT regulatory domains.
Links
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Statistics
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PSSM-Id: 153202
Aligned: 9 rows
Threshold Bit Score: 140.226
Created: 7-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative amino
Feature 1:putative amino acid binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to and mutational studies on phenylalanine hydroxylase and prephenate dehydratase
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         ####           
NP_990136     38 RQSLIEDARKEREaaaaatda-----------aestetiVFEEKDGra---mLNLFFMLKga-kTSPLSRALKVFETFEA 102 chicken
NP_954986     69 RQSLIEDARKEREaavaaaaaavp-----sepgdpleavAFEEKEGka---vLNLLFSPRat-kPSALSRAVKVFETFEA 139 human
AAR23931      38 RQSLIEDARKDREvaaagaa-------------ecadslVFEEKDGka---iVSLLFSLKgs-kPSSLSRTLKVFETFEA 100 African clawed ...
NP_001001829  16 KRSLIEDARRDREsgssspgp-----------srcgdsfVFEEEKTgk--itLNILFALKne-kNAGFFKAGKVFETFET 81  zebrafish
CAA53802      48 KQTVLEEARSKANdyglted------------eillanaASESSDAeaamqsAALVVRLKe--gISSLGRILKAIETFHG 113 fruit fly
AAW47987      48 KQSVLEEARQRANdagltee------------evvlaktIAECPESentvqkAALVLRLRe--gIGSLARILKTIENFKG 113 honey bee
XP_001373552  18 SSVCVESGSEGQKgsmekes------------gspcshpQAEKWEGkegkteMTVLFSLG----KTSLSRIAQVFESFEA 81  gray short-tail...
XP_786206     56 KKSLIEDARRESTrsslditsmslvl-sspeekddvfddAFEPQQEsai-rrFTVTFSSKedmgFGSLSEALRVFQKRKV 133 purple urchin
AAZ32939      33 RRSLIDDARAEKElcrttgrrlssawrqlslseddedleVLDHAEDnyvpvkATIVFSPNd--gFERLPAILDAFKRYHV 110 Florida lancelet

Feature 1             ####                                               
NP_990136    103 KIHHLETRLSRkpr-egtAELEYFVRCEv--hSSDLNTFISSIKRv--AEDVRTTK 153 chicken
NP_954986    140 KIHHLETRPAQrpr-aggPHLEYFVRLEv--rRGDLAALLSGVRQv--SEDVRSPA 190 human
AAR23931     101 KIQHLETRPGRksv-gtaEELEYFVRCEv--hRSDLSTLMSSVRRv--CEDVRSTR 151 African clawed frog
NP_001001829  82 KLLHLESRASRkskrssgEDLEFFMRCEv--hCSDTDIFINSLKRv--ADDVRIVQ 133 zebrafish
CAA53802     114 TVQHVESRQSRve----gVDHDVLIKLDm--tRGNLLQLIRSLRQsgsFSSMNLMA 163 fruit fly
AAW47987     114 TVTHVESRPSKke----gLQFDVLVKVDm--tRQYLLQLIRNLRQssaLDGVTLLA 163 honey bee
XP_001373552  82 KIHHLETRPAPkak-ntlHPLEVFMKFEi--hNSGINLLINSLRKv--VEDVKIHW 132 gray short-tailed opossum
XP_786206    134 TLTHVESRPSNki----dGQIEFLMQCEt--kGSSSKNVLTALQKv--ADNVRLEK 181 purple urchin
AAZ32939     111 KIHHIESRPPQdg----gGDVSVLVRCErdecKGNIPGLVISLKGr--VKSLQLFN 160 Florida lancelet

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