Conserved Protein Domain Family
ACT_TPH

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cd04929: ACT_TPH 
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes. TPH catalyses the hydroxylation of L-Trp to 5-hydroxytryptophan, the rate limiting step in the biosynthesis of 5-hydroxytryptamine (serotonin) and the first reaction in the synthesis of melatonin. Very little is known about the role of the ACT domain in TPH, which appears to be regulated by phosphorylation but not by its substrate or cofactor. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153201
View PSSM: cd04929
Aligned: 9 rows
Threshold Bit Score: 116.314
Threshold Setting Gi: 30580625
Created: 7-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative amino
Feature 1:putative amino acid binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to and mutational studies on phenylalanine hydroxylase and prephenate dehydratase

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ####                ####                                       
Q8IWU9     64 TAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRrrSSEVEIFVDCECgKTEFNELIQLLKFqTTIVTLNP 137 human
NP_990287  18 TAIIFSLKNEVGGLVKALKLFQEKHVNLVHIESRKSKrrNSEFEIFVDCDSnREQLNEIFQLLKShVSIVSMNP 91  chicken
AAN59951   57 AAVVFSLKNEVGGLVKALKLFQENHVNLVHIESRKSKrrNSEFEIFVDCDSnREQLHEIIQLLRKhVNVVEMDA 130 zebrafish
3183183    55 ASVIFSLKNEIGGLVKALKLFQEKHVNLIHIESRKSKrrNSEFEIFVDCDSnREQLNEIFQLLKPhVNVISMSP 128 African clawed frog
BAD01049   46 TPMIFSIKNELGNLAKVLKLFKENDIRVLHIESRKANm-SSELEIFVDCEGkKKMLKNVMDFMKDaMLLTEVMT 118 Hemicentrotus pulcherrimus
NP_612080  79 ISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEmaTNQADVLVDVECdQRRLDQVVKMLNReVASVNYTS 152 fruit fly
XP_394674  47 NSVVFSLKNQIGGLARALQVFQDLGVNVIHIESRKSVrrGSEYEILVDVECdSKRMEQLTRMLSReVAAINLAQ 120 honey bee
ABF18968   88 TTVVFSVNNHVGHLASALKIFQENKINVVHIESRKSRraDSEYDIYVDVETdHIRLEELVNRLKReVASITFNQ 161 California sea hare
XP_967413  50 ISVIFTLKNQVGGLVRALQAFQDLGINVNHIESRPSQlaDNQVDFLVDIDTdQRKLDQLGRLLKReVQTMVIGT 123 red flour beetle

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