Conserved Protein Domain Family
ACT_AKiii-DAPDC_2

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cd04920: ACT_AKiii-DAPDC_2 
ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC)
This CD includes the second of two ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein. Aspartokinase (AK) is the first enzyme in the aspartate metabolic pathway and catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. The lysA gene encodes the enzyme DAPDC, a pyridoxal-5'-phosphate (PLP)-dependent enzyme which catalyzes the final step in the lysine biosynthetic pathway converting meso-diaminopimelic acid (DAP) to l-lysine. Tandem ACT domains are positioned centrally with the AK catalytic domain N-terminal and the DAPDC domains C-terminal. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153192
View PSSM: cd04920
Aligned: 5 rows
Threshold Bit Score: 112.541
Threshold Setting Gi: 83859343
Created: 4-Apr-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_00952864         401 AAVSLVGYGVRRILHKLAPALEMFQdkPIRLVSQAANDLNFTVVVDASEGRALAARLHEELIA 463 Oceanicaulis alexandrii H...
YP_444447           403 AIVSLVGRHIRSLLSELGPAFEVFDeqKVHLVTQAASDLNMSFVVDEDQASRLVRELHAQFFG 465 Salinibacter ruber DSM 13855
ZP_00681627         399 AAITLVGRGMRSLLHKLSEVWATFGkeRVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIE 461 Xylella fastidiosa Ann-1
YP_124092           398 SAVSLVGHHIRTVLPHLGPALEVFEakQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIE 460 Legionella pneumophila st...
REF_jgi:Mmar10_0407 393 AAVSLVGRGVRALLAQFGPAMEAFAhyPVRLVSQAANDLNLTVVVDGDQGKPLCRRLHDQLIQ 455 Maricaulis maris MCS10
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