Conserved Protein Domain Family
ACT_AKiii-YclM-BS_2

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cd04916: ACT_AKiii-YclM-BS_2 
ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII
This CD includes the second of two ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in Bacilli (Bacillus subtilis (BS) YclM) and Clostridia species. Aspartokinase is the first enzyme in the aspartate metabolic pathway and catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. B. subtilis YclM is reported to be a single polypeptide of 50 kD. AKIII from B. subtilis strain 168 is induced by lysine and repressed by threonine and it is synergistically inhibited by lysine and threonine. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153188
View PSSM: cd04916
Aligned: 15 rows
Threshold Bit Score: 88.8507
Threshold Setting Gi: 68196218
Created: 14-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P94417       384 LALIMVVGEAMRHnVGTTARAAKALSeaQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFA 449 Bacillus subtilis
AAO36830     374 MALVAIVGRGMLRtVGMSAKIFDALAreKVNIRMIIQGSSEINIIVGVENEDFEKALKSIYDEFAK 439 Clostridium tetani E88
NP_266896    385 FSIITIVGEDMKEhVGVTARATAALSkqGISIAMLSQGSSEVSVMFIVKEKYEKEALKAIYSAFFD 450 Lactococcus lactis subsp. lac...
YP_193742    386 YAIIMVVGEGMKKtPGVSRQILDSLAsqGITPRMINQGASQISIMIGTKKEKADKAVKIIYQDFFN 451 Lactobacillus acidophilus NCFM
NP_692792    385 LAVIMVVGEGLVNtIGVAARATSSFSkaRVNIEMINQGSSEVSMMFGIHAEDIDKAIQSLYHEFFE 450 Oceanobacillus iheyensis HTE831
AAR21292     180 FAMIMIVGEGMHNtVGVSARMTAALAraNVNIEMINQGSSEVSLVIGIHEKDTDRAVRELYAEFFG 245 Bacillus pseudofirmus
ZP_01163699  386 YAITMVVGEGMRNrTGVIDDILMPLAekHIAVPMINQGASRIAIMIGTYNEDADEAVRAIYHRFFA 451 Lactobacillus reuteri JCM 1112
ZP_00802392  374 MALIAVVGRGMIKtKGISAKVFGALAkeGINVRMITQGSSELNIIVGIENSDFERGISVLYKVFQK 439 Alkaliphilus metalliredigenes...
YP_001037800 384 RALVMIVGEGMMStVGIAARACTALAkaNVNIEMINQGSSEVSMMFGVKAEDNVKAVKALYDEFFS 449 Clostridium thermocellum ATCC...
ZP_01354185  376 LALIAVVGRGMKAtRGTAARIFAALAhsDINIKMIDQGSSELNIIIGVRNEDFDAAIKAIYDIFVI 441 Clostridium phytofermentans ISDg
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