Conserved Protein Domain Family
ACT_AK-Ectoine_2

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cd04915: ACT_AK-Ectoine_2 
ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway
This CD includes the second of two ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium alcaliphilum, Vibrio cholerae, and various other halotolerant or halophilic bacteria. Bacteria exposed to hyperosmotic stress accumulate organic solutes called 'compatible solutes' of which ectoine, a heterocyclic amino acid, is one. Apart from its osmotic function, ectoine also exhibits a protective effect on proteins, nucleic acids and membranes against a variety of stress factors. de novo synthesis of ectoine starts with the phosphorylation of L-aspartate and shares its first two enzymatic steps with the biosynthesis of amino acids of the aspartate family: aspartokinase and L-aspartate-semialdehyde dehydrogenase. The M. alcaliphilum and the V. cholerae aspartokinases are encoded on the ectABCask operon. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153187
View PSSM: cd04915
Aligned: 14 rows
Threshold Bit Score: 96.936
Threshold Setting Gi: 89069071
Created: 21-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAY96773    403 KVSIVSAIGSDMKIPGILAKTVSALAEkQISVLAMHQSMRQVDMQFVIDEDAYTDAMKSLHCHLVE 468 Methylobacter alcaliphilus
CAG35180    399 HTAIVCAIGSNIAKPGILAKATNALATsHINILAVSQTSRQTNMQFIINREHFKEAQRVLHAALCE 464 Desulfotalea psychrophila LSv54
ZP_00754743 397 MVALISAIGAHMETNKVLAQGLQALLEhQLQPMAAHSSMRNVNVQFVVDDADYANGVCVLHQALMP 462 Vibrio cholerae O395
YP_207083   397 MVALIAVIGSQIDTNKALAKGVLSLMNsDVTPVALHSSMRNVNVQFVVSDKDYQNAIKALHHEFCE 462 Vibrio fischeri ES114
YP_133155    48 MVTFISIIGASINTNTALSKGILALTDkQISPIAAHSSMRNVNVQFVVEDKYYKAAICALHSEFIN 113 Photobacterium profundum SS9
ZP_01144939 407 RLAMVALIGSDLSAEGCVGRALDALGAaGIGVKAMQHQMRNVDIQFILDTDRFDDAIRALHAALVE 472 Acidiphilium cryptum JF-5
ZP_00997643 399 TLAMASVIGRDLSTLRVLQRGLCAIADsGHECIGATQGPRNVDVQFVMERDVLKPCIKALHDAFFE 464 Oceanicola batsensis HTCC2597
ZP_01156452 403 ALSLVSVIGRDLRGLRVLSRGLAALDEqEIDVIAAQQTSRRVDSQFVVARDAQSAAVKALHDEFFP 468 Oceanicola granulosus HTCC2516
ZP_01673421 402 KVALVSAIGTNMADTWVLPTAVHSLTNaGVEILGLHKCMRQVDIQFVVDEKDFQNAICALHRDLVE 467 Candidatus Desulfococcus oleov...
ZP_01747952 397 KCALVSVIGRDLTGLSVLTRGMAALEEaDIVPLGAAQGPRSVDVQFIVDHSELSNAIRSLHDVFFP 462 Sagittula stellata E-37
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