Conserved Protein Domain Family
ACT_AKi-DapG-BS_1

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cd04914: ACT_AKi-DapG-BS_1 
ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI
This CD includes the N-terminal of the two ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI, a monofunctional class enzyme found in Bacilli (Bacillus subtilis (BS) strain 168), Clostridia, and Actinobacteria, bacterial species. In B. subtilis, the regulation of the diaminopimelate-lysine biosynthetic pathway involves dual control by diaminopimelate and lysine, effected through separate diaminopimelate- and lysine-sensitive aspartokinase isoenzymes. AKI activity is invariant during the exponential and stationary phases of growth and is not altered by addition of amino acids to the growth medium. The role of this isoenzyme is most likely to provide a constant level of aspartyl-beta-phosphate for the biosynthesis of diaminopimelate for peptidoglycan synthesis and dipicolinate during sporulation. The B. subtilis AKI is tetrameric consisting of two alpha and two beta subunits; the alpha (43 kD) and beta (17 kD) subunit formed by two in-phase overlapping genes. The alpha subunit contains the AK catalytic domain and two ACT domains. The beta subunit contains two ACT domains. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153186
Aligned: 11 rows
Threshold Bit Score: 81.2058
Created: 19-Apr-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q04795      271 VTQFKVPAKIg--qYNVQTEVFKAMAnaGISVDFFNITPSEIVYTVAgnKTETAQRILMd-mGYDPMVTR 337 Bacillus subtilis
ABB15023    275 VTQIKILREDtpeiVNLAQKVFKGLAlaEISVDFINISPEGLAFTVKgeVTEKAVDVLEn-mGFTPRIRR 343 Carboxydothermus hydrogeno...
BAB06119    269 VTQIKVHAKDg--eFDLQEKVFRAMAaeKISVDFININLTGVVYTVMdeVADRAIEVLRe-lGFDPEVKR 335 Bacillus halodurans C-125
AAS42742    271 VTQIKVLAKEt--aYDLQQHVFKEMAneGISVDLINISPTGVAYTVSdnVSNRAVELLQn-lGYEPIVTE 337 Bacillus cereus ATCC 10987
NP_470811   271 LTQIFVKTDT----VKAQQQTFKILAdaGISLDFINISTDSVIFTVPeeKRRVVKQLLEe-aNLQTTVRE 335 Listeria innocua Clip11262
YP_075377   273 LAQVVVKTGR----DWATPRLFRRLAnaGISVDLISVSMESSAFSIPesRAAQAEMILTelgLVDLQVRH 338 Symbiobacterium thermophil...
BAB81384    266 RIQVSIKSDDnk-dNINYKTILESLAnnKISLDLINIFPKEKVFTIDagVKELFEDIMRk-nNLKYSLVE 333 Clostridium perfringens st...
NP_781912   265 RTQIKIELEQnk-eNESYFRILDILAenSISIDLINVFPRESIFTIDgkDFEKFSSIMNk-iNLKYSHID 332 Clostridium tetani E88
AAK79775    266 RVQVTTKFKDs---KIKSTEFLSLLGerNINIDLINVFPKENIFTIDkkDLNKLKDTLIk-tKVQYYLED 331 Clostridium acetobutylicum...
GAA02267    306 ITQFRIPMDGcgdtAGLQRRMFEALAlaGISIDFINVHPDVVIFTVKnsVAAKAAQILEn-mGLRPSILP 374 Pelotomaculum thermopropio...
ZP_01147878 272 VTQLKIIAKDia-vEDPALRIFRALAlaDISIDFINVSPELIMLTVKdeVAKKAVDVLEn-lSVFPQVKP 339 Desulfotomaculum reducens ...
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