Conserved Protein Domain Family
ACT_AKiii-YclM-BS_1

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cd04911: ACT_AKiii-YclM-BS_1 
ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII
This CD includes the first of two ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in Bacilli (Bacillus subtilis (BS) YclM) and Clostridia species. Aspartokinase is the first enzyme in the aspartate metabolic pathway and catalyzes the conversion of aspartate and ATP to aspartylphosphate and ADP. Bacillus subtilis YclM is reported to be a single polypeptide of 50 kD. AKIII from Bacillus subtilis strain 168 is induced by lysine and repressed by threonine and it is synergistically inhibited by lysine and threonine. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153183
View PSSM: cd04911
Aligned: 19 rows
Threshold Bit Score: 101.921
Threshold Setting Gi: 68196218
Created: 19-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
allosteric
Feature 1:allosteric regulatory residue
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                                      
P94417          307 FCSIYISKYLMNREIGFGRRALQILEEHGLTYEHVPSGIDDMTIILRQGQMdaatERSVIKRIEEDLHADEVIVEH 382 Bacillus subtilis
AAO36830        298 FVVIAIEKNMMNIEQGYCRKVLSVLEENYVSFEHMPSGVDAVSLVISKNQLng-kLDGILEEIEMKCKPDSIEVYP 372 Clostridium teta...
REF_tigr:SE0896 308 FTVINIKKYLMNRLVGFTRKILGVLEDYNISFDHMPSGIDNISIIMRTNQIqg-kESQVLNAIRKRCEVDELSIDH 382 Staphylococcus e...
NP_785785       308 FCSLYLRKYLLNKEVGLGRKILTILENHHISYEHMPSGIDDLTIIFDEHQLtpelEKTLVAEISTAINPDEIYFTH 383 Lactobacillus pl...
NP_814159       307 FASIYISKYLMNRELGFGRRLLEVLEKLALSYEHMPSGIDDITIVLREDQLtteiENRLMAQLQEVLAPDELRITH 382 Enterococcus fae...
AAK78259        297 FTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLdg-kCDKIIEEIKKQCNPDSIEIHP 371 Clostridium acet...
ZP_00802392     298 FTVIAIEKMLMNAEKGFIHKLLTILEANGISAEHMPSSIDSISLVISDKGLkn-nIQKVINEIRVQTNPDSIVAYP 372 Alkaliphilus met...
YP_803686       311 FAALYIHKYLLNREVGFTLKLLKILYRYDISYEHMPSGIDDLTIIFNQNQItdeiLPSLLSDIREELHTDQLEWID 386 Pediococcus pent...
YP_878691       298 FTTIVIQKTYMNAEIGFGRRLLSALETYGISFEHMPSGIDTISIVIDDAQLdn-kLDKLLEEIKRQCNPDSIHVIP 372 Clostridium novy...
ZP_01354185     300 FCSINIEKAMMNTEVGFGRKVLEVFEKNNISFEHVPSGIDTFTVFVHQSEFee-kEQKVLAGIHKLVEPDSIDMEG 374 Clostridium phyt...

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