Conserved Protein Domain Family
ACT_AK-Ectoine_1

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cd04910: ACT_AK-Ectoine_1 
ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway
This CD includes the first of two ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium alcaliphilum, Vibrio cholerae, and various other halotolerant or halophilic bacteria. Bacteria exposed to hyperosmotic stress accumulate organic solutes called 'compatible solutes' of which ectoine, a heterocyclic amino acid, is one. Apart from its osmotic function, ectoine also exhibits a protective effect on proteins, nucleic acids and membranes against a variety of stress factors. de novo synthesis of ectoine starts with the phosphorylation of L-aspartate and shares its first two enzymatic steps with the biosynthesis of amino acids of the aspartate family: aspartokinase and L-aspartate-semialdehyde dehydrogenase. The M. alcaliphilum and the V. cholerae aspartokinases are encoded on the ectABCask operon. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153182
View PSSM: cd04910
Aligned: 12 rows
Threshold Bit Score: 92.7403
Threshold Setting Gi: 50875340
Created: 21-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
allosteric
Feature 1:allosteric regulatory residue
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           #                                   
AAY96773    330 VYAFEVFDQNMAGeiHNYDREILGQIRRFRAHIVSKDiNANTITHYLSaslktIRRIRDALQEIYpdAEINQ 401 Methylobacter alcaliphilus
CAG35180    330 VTCLEVHDTRMVGe-VGFDMKIMEVLSAHQVSYINKAtNANTIGVIVYdn-dcTEELLRDLRAEF--ELVTD 397 Desulfotalea psychrophil...
ABA57537    330 VFAIEFFEQDMVGs-SGYDTQLLALLERFKLKIVAKDtNANTITHFVAsslkaIKRVTHAMEDAFpsAAVAV 400 Nitrosococcus oceani ATC...
NP_798098   324 VFALHLFDQAMVGkvDNVSYELMEIISDARVSLIGKEmNANSITYYLGgssdsLNKVLYKAEKRYpnASIKG 395 Vibrio parahaemolyticus ...
ZP_01116730 329 IYAIEVFDQDMAGlfHTYDPKIVSVIKEYKAHIVSKDiNANTVTHYLQtnlktIKRIRKKLETLFpeAEVDQ 400 Reinekea sp. MED297
YP_760351   329 VFALEVFDQDMVGe-KGYDSTILDALTRHSIRIVSKCsNANTITHYIEgsrkaLKRATADIETKLpgAEVST 399 Hyphomonas neptunium ATC...
ZP_01596487 331 VFAVELFDQDMAGdiDKFDVDILKVLRQFHAHIIAKDiNANTITHYLAinlktLKRVMRVLHERFadAEITQ 402 Marinomonas sp. MWYL1
ZP_01113085 330 VYALNVFDQDMVGe-PHQFLEIQQLVQEFNVPLLAKEhNANTVTLYLDtglkvVERIQARLERHFpnAEMTS 400 Reinekea sp. MED297
ZP_01673421 330 VTGIEVWDQDMVGr-WDHDLEMLKHLAAAKIRYLAKDtNANTLTHYIAaplakIKRLTDNIKQDFpsADILV 400 Candidatus Desulfococcus...
YP_390791   358 LIALEVFDQEMMGqqGSYEKVIIDATNRLKCQVITKDfNANTITIYLKaslkkVKRLAEQLKQGLptATINT 429 Thiomicrospira crunogena...
ZP_01168384 330 VFGIEIFDQEMLGd-AKYDIEISKLLAQLKLYVINKDaDANSITYYVGgsrkmVNRAANLMENMYpeGQIRL 400 Oceanospirillum sp. MED92
YP_465024   352 VSAVEIHDPSMVGt-VGFDLGVMEIFQRHGISYILKAtNANSITHVVWek-svSSAFVEELENQY--QKVTV 419 Anaeromyxobacter dehalog...

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