Conserved Protein Domain Family
ACT_PDH-BS

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cd04909: ACT_PDH-BS 
C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH)
The C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate, found in Bacillus subtilis (BS) and other Firmicutes, Deinococci, and Bacteroidetes. PDH is the first enzyme in the aromatic amino acid pathway specific for the biosynthesis of tyrosine. This enzyme is feedback-inhibited by tyrosine in B. subtilis and other microorganisms. Both phenylalanine and tryptophan have been shown to be inhibitors of this activity in B. subtilis. Bifunctional chorismate mutase-PDH (TyrA) enzymes such as those seen in Escherichia coli do not contain an ACT domain. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153181
View PSSM: cd04909
Aligned: 18 rows
Threshold Bit Score: 86.133
Threshold Setting Gi: 12724765
Created: 5-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAA20868    298 FYDLYVDVPDhPGVISEITAILAaeRISITNIRIIETREd-INGILRISFQSddDRKRAEQCIEaraEYET 367 Bacillus subtilis
CAD64408    293 FYDLFLNVPDrVGALADVTQRLAqaQLSLVNIHILEIREe-IDGVLQLTFSDlkTRTQASSLLAd-aGYQI 361 Lactobacillus plantarum W...
AAK05843    285 FYDLFISVPDeKGVVLKVLGLLE--DFSITNVKINEENRedIHGQLQISFKRaeDLKEAREIIEkatDFTV 353 Lactococcus lactis subsp....
ABB14686    289 LYDLTANIPDrPGMLAKVTGLLArfNINIKDIEILKAREg-DGGVLKLSFATfeERQKAFSLLEk-eGYRP 357 Carboxydothermus hydrogen...
AAF10695    297 RHDLVVALPDrPNQIRAVTQALGaeRVNIKDIEVLAIRE--DGGSLRLGLESpeDAARAAVILRe-aGFEV 364 Deinococcus radiodurans R1
ZP_00874742 296 FYDLFLSVPDeEDTILKVLEVLR--GISIVNIRINEENRedIHGILQITFKNkgNLEDAAKRLReqtTYKI 364 Streptococcus suis 89/1591
BAD70622    291 MHDLVVQVPDrPGEIARIATALGeaGVNIKDIEVLTIRE--AAGALRLSFATreERERARRVLQe-aGYRL 358 Thermus thermophilus HB8
YP_445736   310 LSDVYVRAPDeEGVIHELSGHLLdaDLNIKDIELQTIRDg-TGGTFRLAFETagDAEEAVAVLSa-aGYEA 378 Salinibacter ruber DSM 13855
YP_430189   301 LHELVVTVPDrPGVIGAMATSLGdaGINIIDIEILRVREg-EGGSIRLGFTTaaAATRALEILQn-sGINV 369 Moorella thermoacetica AT...
GAA00307    327 LFEIVAAIPDqPGALARLTAHLAgaGINITDIEILRVREg-EGGTVRVGFATesEQEGSYRLLKe-kGYTV 395 Pelotomaculum thermopropi...
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