1TDJ


Conserved Protein Domain Family
ACT_ThrD-I_1

?
cd04906: ACT_ThrD-I_1 
Click on image for an interactive view with Cn3D
First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase)
This CD includes the first of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase) which catalyzes the committed step in branched chain amino acid biosynthesis in plants and microorganisms, the pyridoxal 5'-phosphate (PLP)-dependent dehydration/deamination of L-threonine (or L-serine) to 2-ketobutyrate (or pyruvate). ThrD-I is a cooperative, feedback-regulated (isoleucine and valine) allosteric enzyme that forms a tetramer and contains four pyridoxal phosphate moieties. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
?
PSSM-Id: 153178
View PSSM: cd04906
Aligned: 37 rows
Threshold Bit Score: 112.256
Threshold Setting Gi: 135721
Created: 16-Mar-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Ile/Val binding site [chemical binding site]
Evidence:
  • Comment:based on comparison with related structures and other data, these residues may be involved in effector binding
  • Citation:PMID 9562556

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    ######                                                              
1TDJ         338 EALLAVTIPEeKGSFLKFCQLLGGRSVTEFNYRFADa-kNACIFVGVRLsrg----leERKEILQMLNDg-gYSVVDLSD 411 Escherichia coli
AAG10439     337 EKILSIKIPEiPGSFLKLSRMFGSSQVTEFNYRKSSl-sDAYVLVGVRTkt-----ekSFEILKSKLKKa-gFTFSDFTR 409 uncultured mari...
P25306       419 EALLATFMVEqQGSFKTFVGLVGSLNFTELTYRFTSerkNALILYRVNVdk-----esDLEKMIEDMKSs-nMTTLNLSH 492 Lycopersicon es...
NP_187616    418 EAVLATLMPEkPGSFKQFCELVGPMNISEFKYRCSSe-kEAVVLYSVGVht-----agELKALQKRMESs-qLKTVNLTT 490 thale cress
XP_460463    389 EVSLAVTIPErPGEFAILQNIIDPRAITEFSYRFNNs-gPANIFVSFNVtnk----dkELAPIVESMKSn-dYEVIDISE 462 Debaryomyces ha...
XP_752012    389 EALLSVKIPEkPGAFANLVEVILPQAVTAFSYRYARa-eSADVLMGISLsalt--greDLAKIMDQLEKa-gMPAKDLSD 464 Aspergillus fum...
XP_959505    403 EALLSVTIPErPGAFAELVNAIMPHAITEFSYRYATe-sKANVMVGISLadsgsrraeQLQTIIGRIKQsgdMDVTDLSA 481 Neurospora cras...
XP_367299    427 EALLAARIPEkPGSFAKLIEAIMPNNVTEFTYRYTDg-eVANIMLGLSLtapvaqrahQLQLLMGRIAEa-gMEVTDLSG 504 Magnaporthe gri...
ZP_00422605  328 EARFAVSIAErPGSFRALIEQLGDCVVTAFDYRRATg-gDAQVFVGVRTpg-----aeGARKIVQDLAAa-gYRATDLGG 400 Burkholderia vi...
XP_001241652 384 EALLSVTITEqPGSFAKLVEIIMPHDITEFSYRCATt-sSADILMGISLsast--gmaDLADLKLQIERd-gMSVTEVTD 459 Coccidioides im...
Feature 1                   
1TDJ         412 DEMAKLHVRYM 422 Escherichia coli
AAG10439     410 NEISNDHLRHM 420 uncultured marine gamma proteobacterium EBAC31A08
P25306       493 NELVVDHLKHL 503 Lycopersicon esculentum
NP_187616    491 SDLVKDHLRYL 501 thale cress
XP_460463    463 NELAKTHGRYL 473 Debaryomyces hansenii CBS767
XP_752012    465 DELAKRHVRFL 475 Aspergillus fumigatus Af293
XP_959505    482 DELAKSHLRYM 492 Neurospora crassa N150
XP_367299    505 DELAKSHVRYL 515 Magnaporthe grisea 70-15
ZP_00422605  401 STLWRTHGHQL 411 Burkholderia vietnamiensis G4
XP_001241652 460 DELAKTHIRYL 470 Coccidioides immitis RS

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap