Conserved Protein Domain Family
ACT_LSD

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cd04903: ACT_LSD 
C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit
The C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit, found in various bacterial anaerobes such as Clostridium, Bacillis, and Treponema species. These enzymes catalyze the deamination of L-serine, producing pyruvate and ammonia. Unlike the eukaryotic L-serine dehydratase, which requires the pyridoxal-5'-phosphate (PLP) cofactor, the prokaryotic L-serine dehydratase contains an [4Fe-4S] cluster instead of a PLP active site. The LSD alpha and beta subunits of the 'clostridial' enzyme are encoded by the sdhA and sdhB genes. The single subunit bacterial homologs of L-serine dehydratase (LSD1, LSD2, TdcG) present in Escherichia coli, and other enterobacterials, lack the ACT domain described here. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153175
View PSSM: cd04903
Aligned: 30 rows
Threshold Bit Score: 69.8694
Threshold Setting Gi: 6458183
Created: 18-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative L-serine binding site [chemical binding site]
Evidence:
  • Comment:based on homology to the E. coli 3PGDH ACT domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # #                 #                                              
BAB82329    149 TLIISHKDvPGAVSKVTAIVYehNINIAFMKVFRTeRGKAARMVFEMDSp-iTKDIIDEIKKVeAVEKLVVI 219 Clostridium perfringens ...
NP_266986   152 TFVVIHEDvPGMIARVSSVLSehQINIAQMNVTREaKGEKAIMILEVDTp-nVKEVIEEMKLIpRLHAVNFF 222 Lactococcus lactis subsp...
NP_736534   151 TLIIVHQDiPGMIAKVTDILSdfNINIAQMNVTREsAGEKAIMIIEVDSr-dCQQAVKKIEAIpHLHNVNFF 221 Streptococcus agalactiae...
NP_816353   151 TFIVVHQDvPGMIAKVTNILSasDINISTMTVTREsKGEKAIMIIEVDQa-eVGDIVMQLAEIpHIYSVNYF 221 Enterococcus faecalis V583
NP_972113   146 TLVVEYQDiPGRIAAITSVTAkhKINISQIHIGRDyRGGTATMCLQMDGlsvGPELKEDILQIdHIYNVILI 217 Treponema denticola ATCC...
YP_144005   145 TLVIKNVDtPGVVARVARILAddEVNIAYLTVSRKkRGGEAMMSIEVDRp-lSEVPLRYLEHLsYILWVRQI 215 Thermus thermophilus HB8
AAF10074    162 TLLLRYTDaVGMIARIASSIAaaGVNIAALTCTRAaRGGQALLAIELDAp-pSPEALSFIASWqDVNWVRLL 232 Deinococcus radiodurans R1
ZP_01352286 150 TLVIRHHDyPGMVAYIATSLSerNVNIAFMRLFRErKGATAYSVVESDEe-iPRELLEKLREHpKVEDVMLI 220 Clostridium phytoferment...
ZP_01190195 145 TLWVLHRDkPGEVGIITSILGcyKLNIAFMRVFRKkRGTIGSSIIELDQd-vDEDIIDHLQGMkDILKVRYI 215 Halothermothrix orenii H...
EBA40360    157 TLFVAHKDvPGVLAALTNLLAyaHVNIAFCRTYRTeVGGQAYSVFETDGa-pDDTVVPMLRKLdNVDYATFI 227 Collinsella aerofaciens ...

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