1U8S


Conserved Protein Domain Family
ACT_GcvR_1

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cd04893: ACT_GcvR_1 
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ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains
This CD includes the first of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains. The glycine cleavage enzyme system in Escherichia coli provides one-carbon units for cellular methylation reactions. This enzyme system, encoded by the gcvTHP operon and lpd gene, catalyzes the cleavage of glycine into CO2 + NH3 and transfers a one-carbon unit to tetrahydrofolate, producing 5,10-methylenetetrahydrofolate. The gcvTHP operon is activated by the GcvA protein in response to glycine and repressed by a GcvA/GcvR interaction in the absence of glycine. It has been proposed that the co-activator glycine acts through a mechanism of de-repression by binding to GcvR and preventing GcvR from interacting with GcvA to block GcvA's activator function. Evidence also suggests that GcvR interacts directly with GcvA rather than binding to DNA to cause repression. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153165
View PSSM: cd04893
Aligned: 11 rows
Threshold Bit Score: 110.875
Threshold Setting Gi: 24982685
Created: 22-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1U8S_B        6 HLVITAVGTDRPGICNEVVRLVTQAGCNIIDSRIAMFGkEFTLLMLISGSpSNITRVETTLPLLGQQhDLITMMKRT 82  Vibrio cholerae
YP_269881     4 YLVLTAMGSDRTGCVSELTKLASECECNILDSRMAIFGsEFTFIMLLTGDtRAINKIEMKIPQLAHSlDLITMMKRT 80  Colwellia psychrery...
YP_201563    36 HLLINAYTTHPESPLLPVTRRIADSGCNLLDARLATVGrDVSVTALATGSwDSVAKLEAMLTRLEREeGLKLVWYRT 112 Xanthomonas oryzae ...
AAN66860     10 FLVISALGPNPMELANVLSRAAFENRCAVVTSRLSRHGeTSALVLQVGGSwDALARLESTLPGLGKKhGLTLDVVRS 86  Pseudomonas putida ...
ZP_01126785   5 FLVVSALGEDRPGIVNELSRIIAESGCNIEDSRMTVLGgEFAIILLAEGRwNKLAKLEAALPSLGRRlGLTVNSKRT 81  Nitrococcus mobilis...
YP_436023    10 YLVISAIGEDRPGIVNELAKACSDYQCNIVDSRMTVLGaEFALVMMVSGSwDAIAKLENIIPPLARKlDLNLIIKQT 86  Hahella chejuensis ...
ABA58978      4 HLVISAIGHEQPGLLKELTSAILDSGCSIEDSRMVLLGtKFTIQLLVSGSwSAVAKLEAMLPGLKQRlTLTILSKRT 80  Nitrosococcus ocean...
ZP_01111347   5 QLIVTILGTDNSGILSEIATTVSEAQCNILDSRQAIYGkEFSLTMIIEGTqSAITKAECILPALFQRlDLLSMMKRT 81  Alteromonas macleod...
ZP_01449877   4 QLIINFLGVDKPGLLSAIASTINTANCNILDSRQAIFGqELSITMIIEGNqNAITKAEVAIPTLCHElDLLAMMKRT 80  alpha proteobacteri...
YP_692495    14 LIVISALGTDRPGIVQALSKAVLEYDGNIMDSRMTVLGgEFAVLMLVAGNaATLDSLEAGQQQLADQlNLRITLKRT 90  Alcanivorax borkume...
YP_113178     2 QIVATILGADRLNLIADIGQVVSECRCTLLESRLTELGtEFAGHLMVEGNwNHIARFESALENLAARyALKIHMRRL 78  Methylococcus capsu...
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