2F06


Conserved Protein Domain Family
ACT_PDH-BS-like

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cd04889: ACT_PDH-BS-like 
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C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
Included in this CD is the C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate, found in Bacillus subtilis (BS) and other Firmicutes, Deinococci, and Bacteroidetes. PDH is the first enzyme in the aromatic amino acid pathway specific for the biosynthesis of tyrosine. This enzyme is feedback inhibited by tyrosine in B. subtilis and other microorganisms. Both phenylalanine and tryptophan have been shown to be inhibitors of this activity in B. subtilis. Bifunctional chorismate mutase-PDH (TyrA) enzymes such as those seen in Escherichia coli do not contain an ACT domain. Also included in this CD is the N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains as seen in the uncharacterized structure (pdb 2F06) of the Bt0572 protein from Bacteroides thetaiotaomicron and related ACT domains. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153161
View PSSM: cd04889
Aligned: 40 rows
Threshold Bit Score: 49.0411
Threshold Setting Gi: 24379240
Created: 26-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2F06_A        9 LSIFLEnkSGRLTEVTEVLAkeNINLSALCIAena--dfGILRGIVSd---pDKAYKALK 63  Bacteroides thetaiotaomicron VPI-5482
ZP_01186604 300 LYVDVLdkVGALAHITSILAeeEISITNLQILearegllGVLRISFQreedrTQAKIALG 359 Bacillus weihenstephanensis KBAB4
BAC13737    298 VYVDIHdqSGAIAKVVQILAdeNFSIKNIEILevregitGVLRLSFHtqkeqIGSSKKLT 357 Oceanobacillus iheyensis HTE831
CAD64408    296 LFLNVPdrVGALADVTQRLAqaQLSLVNIHILeireeidGVLQLTFSdlktrTQASSLLA 355 Lactobacillus plantarum WCFS1
ABB14686    292 LTANIPdrPGMLAKVTGLLArfNINIKDIEILkaregdgGVLKLSFAtfeerQKAFSLLE 351 Carboxydothermus hydrogenoformans Z-...
AAF10695    300 LVVALPdrPNQIRAVTQALGaeRVNIKDIEVLair-edgGSLRLGLEspedaARAAVILR 358 Deinococcus radiodurans R1
BAD70622    294 LVVQVPdrPGEIARIATALGeaGVNIKDIEVLtir-eaaGALRLSFAtreerERARRVLQ 352 Thermus thermophilus HB8
YP_445736   313 VYVRAPdeEGVIHELSGHLLdaDLNIKDIELQtirdgtgGTFRLAFEtagdaEEAVAVLS 372 Salinibacter ruber DSM 13855
YP_430189   304 LVVTVPdrPGVIGAMATSLGdaGINIIDIEILrvregegGSIRLGFTtaaaaTRALEILQ 363 Moorella thermoacetica ATCC 39073
GAA00307    330 IVAAIPdqPGALARLTAHLAgaGINITDIEILrvregegGTVRVGFAteseqEGSYRLLK 389 Pelotomaculum thermopropionicum SI
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