Conserved Protein Domain Family
ACT_ThrD-II-like

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cd04886: ACT_ThrD-II-like 
C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains
This CD includes the C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains. The Escherichia coli tdcB gene product, ThrD-II, anaerobically catalyzes the pyridoxal phosphate-dependent dehydration of L-threonine and L-serine to ammonia and to alpha-ketobutyrate and pyruvate, respectively. Tetrameric ThrD-II is subject to allosteric activation by AMP, inhibition by alpha-keto acids, and catabolite inactivation by several metabolites of glycolysis and the citric acid cycle. Also included in this CD are N-terminal ACT domains present in smaller (~170 a.a.) archaeal proteins of unknown function. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153158
View PSSM: cd04886
Aligned: 75 rows
Threshold Bit Score: 54.0862
Threshold Setting Gi: 2842611
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_951545   328 LKVELDDLPGALARLATEIAeAKANISIITHDRRsks-lpiGKTEVLIELETrg-feHIQEVISHLQgvGYLVDV 400 Geobacter sulfurreduc...
AAL64106    328 LVGEVPDKPGTLAKASSFLAsHNVNILEVFHERYdpe-qrpNYVRLIFVVEIpg-tlDVSKLLDELEknGFFFRV 400 Pyrobaculum aerophilu...
NP_696683   340 FEVELPDTPGQLVKVATLLAeQRANVIQLDHDQFkasghytNAVSLGVTVETng-peHIDRILAALReaGFQPKR 413 Bifidobacterium longu...
ZP_00802751 290 FTVALPDKPGELLKVSEILTrLNGNVIKLDHNQFknl-drfMEVELEVTVETng-hqHINQITTELNkaGYNILK 362 Alkaliphilus metallir...
ZP_00912096 326 VSVLLPDKPGELTNVSKVIAeAHGNIIKLDHNQFvsi-nrnSAVELDITMETfg-hdHKEAIIKALKdsGYDPKV 398 Clostridium beijerinc...
CAE09296    329 FSVILVDKPGSLKGLTDILSqVGANIVRIDYDRTsts-layGDANVTIALETkg-geHQEEIRQELWkyHYRFVE 401 Wolinella succinogenes
NP_562081   328 FSLEVPHKPGQILKIAKVLAdTNANIVKLEHDHFkar-dalKNMVIEVTLETng-hsHIEEIKKALTdqNYVIKQ 400 Clostridium perfringe...
ABK77476    314 VFILLPDKPGALKEVVDEITsANANIVEVVHDRFsse-inaGSAGVTLSLETqg-agAADGLVRHLRdrGIIFRL 386 Cenarchaeum symbiosum
ZP_01711096 230 LKGLIPDRPGMLAQVTGVLGrLGVNIVEIRHERYnpl-irpNYTEVDVIVETppeegAVDRVIEELSrlGFNFKV 303 Caldivirga maquilinge...
YP_920018   335 IQGVLPDKPGQLKKVIDVVSeLGLNIVEIQHERLnpl-lspGMAQVTLGLEVps-reYADMLILKLKaqGLDFKV 407 Thermofilum pendens H...
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