1TDJ,1TDJ


Conserved Protein Domain Family
ACT_ThrD-I

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cd04885: ACT_ThrD-I 
Click on image for an interactive view with Cn3D
Tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase)
This CD includes each of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase) which catalyzes the committed step in branched chain amino acid biosynthesis in plants and microorganisms, the pyridoxal 5'-phosphate (PLP)-dependent dehydration/deamination of L-threonine (or L-serine) to 2-ketobutyrate (or pyruvate). ThrD-I is a cooperative, feedback-regulated (isoleucine and valine) allosteric enzyme that forms a tetramer and contains four pyridoxal phosphate moieties. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153157
View PSSM: cd04885
Aligned: 76 rows
Threshold Bit Score: 67.5309
Threshold Setting Gi: 116508333
Created: 16-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Ile/Val binding site [chemical binding site]
Evidence:
  • Comment:based on comparison with related structures and other data, these residues may be involved in effector binding
  • Citation:PMID 9562556

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ######                                                     
1TDJ        341 LAVTIPEeKGSFLKFCQLLGGRSVTEFNYRfadaknACIFVGVRlsrgleerKEILQMLNDggySVVD 408 Escherichia coli
ZP_01078731  79 IAVKIPEsPGSFRSFCQALETRNITEFNYRysdpeqAAIFVGVQlgghphsrENLLDDLKDy--EIVD 144 Marinomonas sp. MED121
ZP_00422605 331 FAVSIAErPGSFRALIEQLGDCVVTAFDYRratggdAQVFVGVRtpga-egaRKIVQDLAAagyRATD 397 Burkholderia vietnamiensis G4
ZP_00767370 333 FAVTIPErPGSFKQFCRVIGPHNITEFNYRyaprpeANVFVGVQltna-nqrHELAERMRNagyTVLD 399 Chloroflexus aurantiacus J-1...
AAF10147    396 LAVTIPErPGAFLEFIELIGSRAITEFNYRyapredARIFVGVQlgqp-gerQELLTLLRGrgyAVLD 462 Deinococcus radiodurans R1
ZP_01092688 354 IAVSIPEqPGSFKRLCELLGTRGITEFNYRmsdktqAHVFVGLTtsnr-qdtADMIEKLNRhafAAVD 420 Blastopirellula marina DSM 3645
ZP_01104074 331 ISVTIPEkPGAFRKFCNSIGRRNITEFNYRyssakdARVFVGVTvepggedlKALIDQLAGegyECED 398 gamma proteobacterium KT 71
AAU90541    331 LAVTIPErPGSFLEFCRVLGRRNITEFNYRffdekaAQVFVGLPvasgaidrESLVREFERqgfGVLD 398 Methylococcus capsulatus str...
YP_432369   331 LAVKIPErPGSYKRFIQALSRRNITEFNYRycdateAQIFVGVQissgleerKELVGALEEkgySVLD 398 Hahella chejuensis KCTC 2396
ZP_01450306 337 FAVKIPEvTGSFKRFCEVLGGINITEFNYRfanaeqAYVFVGVKlkrgleeyAELTATLAQngyEAVD 404 alpha proteobacterium HTCC2255

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