Conserved Protein Domain Family
ACT_HSDH-Hom

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cd04881: ACT_HSDH-Hom 
ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains
The ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) encoded by the hom gene of Bacillus subtilis and other related sequences. HSDH reduces aspartate semi-aldehyde to the amino acid homoserine, one that is required for the biosynthesis of Met, Thr, and Ile from Asp. Neither the enzyme nor the aspartate pathway is found in the animal kingdom. This mostly bacterial HSDH group has a C-terminal ACT domain and is believed to be involved in enzyme regulation. A C-terminal deletion in the Corynebacterium glutamicum HSDH abolished allosteric inhibition by L-threonine. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153153
View PSSM: cd04881
Aligned: 79 rows
Threshold Bit Score: 59.8368
Threshold Setting Gi: 50954437
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6648065     349 QFLRIHVKDEVGSFSKITSVFSerGVSFEKILQLPikgh----delAEIVIVTHHTSEADFSDILQNLNDLEVVqe-vkS 423 Bacillus subtilis
YP_076568   351 YYLRLHAVDAPGSLARIAERFGehGVSLAEVVQASggpdhpddggaAELVLVTHTVQDANLQAVVRDLKEMRDTvlrvdN 430 Symbiobacterium ...
AAK78974    349 YYVRITVKDLPGVLGEISMIFGeeGVSLLSVMQKGkre------ecVTVVYFTHSANEGMIKSAIDRIKSSKYTks-vdN 421 Clostridium acet...
AAO36829    348 YYIRITVGDKPGVLGEITTILGenNVSLLSVIQKGkrq------ehASLVFVTHRTNEGDVQKAIEKISGLSDVlk-vdN 420 Clostridium teta...
NP_624136   339 YYIRLIAFDRPGVMSKITGVLGnkGISLLSVVQKGslg------etAEIVLVTHIANTGKVLEALKEIEELKEVek-ieS 411 Thermoanaerobact...
NP_927241   347 FYIRLRALDRPGVVGHIGQIFGrhSVSLASIVQKNprg------aaAELVIITHDVAEARLRAALAELRASSEVqd-fcT 419 Gloeobacter viol...
ZP_00802063 353 YYIRVMVKDRPAVLGKIASLIGdsGVSLSTVIQKGegd------psVSLVFITHRTNEGNIKRALDAIIAVPEVve-laN 425 Alkaliphilus met...
YP_877001   349 YYIRMTVNDEPGVLGNIAGILGkhDVSLLSVIQKAkee------esVKLVFITHKTLEGNINKSMEEMKKLSSVqs-ieN 421 Clostridium novy...
GAA00328    351 YYIRLKVADKPGVLAGIAFVLGsnEVSLASVIQKHtdg------kfAEIVLVTHEVLERNLQDALRIIKELSTVne-isN 423 Pelotomaculum th...
ZP_01667612 350 YYIRMLVEDKPGVLAAIAGAFGaqQVSLHSVIQKRkvd------nwAEVVLITYRVSHASLRLAINTIEGMSIVgk-vqN 422 Thermosinus carb...
6648065     424 TYRVE 428 Bacillus subtilis
YP_076568   431 VIRVE 435 Symbiobacterium thermophilum IAM 14863
AAK78974    422 IIRIE 426 Clostridium acetobutylicum ATCC 824
AAO36829    421 IIRIE 425 Clostridium tetani E88
NP_624136   412 VIKVR 416 Thermoanaerobacter tengcongensis MB4
NP_927241   420 AIRVL 424 Gloeobacter violaceus PCC 7421
ZP_00802063 426 LIRVE 430 Alkaliphilus metalliredigenes QYMF
YP_877001   422 IIRVE 426 Clostridium novyi NT
GAA00328    424 VIRVE 428 Pelotomaculum thermopropionicum SI
ZP_01667612 423 VIRVE 427 Thermosinus carboxydivorans Nor1
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