Conserved Protein Domain Family
ACT_F4HF-DF

?
cd04875: ACT_F4HF-DF 
N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase)
This CD includes the N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase) which catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to FH4 and formate. Formyl-FH4 hydrolase generates the formate that is used by purT-encoded 5'-phosphoribosylglycinamide transformylase for step three of de novo purine nucleotide synthesis. Formyl-FH4 hydrolase, a hexamer which is activated by methionine and inhibited by glycine, is proposed to regulate the balance FH4 and C1-FH4 in response to changing growth conditions. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
?
PSSM-Id: 153147
View PSSM: cd04875
Aligned: 88 rows
Threshold Bit Score: 59.881
Threshold Setting Gi: 57167791
Created: 9-Aug-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ZP_00379373   5 VFTLECDERPGITHAVTGALLthGGDIKELKQFddQYTERLFLRIDFSLqdesqgaIEALRADFEGIGtd-fEASW 79  Brevibacterium linen...
2984098       5 ILLVSCPDRKGLVKEISSFIAdnGGNIVSFDQHidEQTKTFLARVEWSLedf-kipREKIENEFKKVAqk-fSMNF 78  Aquifex aeolicus VF5
AAO76488      5 KLLLHCPDKPGILAEVTDFITvnKGNIIYLDQYvdHVENIFFMRIEWELkdf-lvpQEKIEDYFRTLYgqkyEMDF 79  Bacteroides thetaiot...
ZP_01126394  11 ILLMHCADQQGLVAAISEFIArnEGNIVYLDQHvdERRGIFFMRVEWELarf-rvaVEAIDKAFDEAIgqrfGMHW 85  Nitrococcus mobilis ...
ZP_01052420   7 TFLIQCPDQKGLVAKITSFFFekGFNILSCQQYvnALENTYFMRIRLNSegs-disKSSLEKDFLDLAtp-lDFKW 80  Tenacibaculum sp. ME...
ZP_01107962  11 TILIHCPDQSGIISAVTTFIHsrGGNITYLDQHvdQQADVFFMRLESDFkkn-afqPIDFKNEFNSTLadhyQMEW 85  Flavobacteriales bac...
ZP_01050855   5 TLLIHCKDQKGIIASVTNFILenEGNTTYIDQHvdAVANVFFMRLECVFtna-sfnTAQFKAAFKEKLatpfEMQW 79  Cellulophaga sp. MED134
ZP_01059115   5 TLLINCPDRKGIVTTITQFILerQGNIVYLDQHvdRQESIFFMRVESEFdqe-gfsIADFEMQFIAQFvddyQLTY 79  Flavobacterium sp. M...
ZP_01718343   5 ILLIQCPDQKGIVAEVSRFLYsyQGNILEIDQHvdKGLSLFFMRAAWELdsf-sleKEKIAQQFEKEVgakfKMDF 79  Algoriphagus sp. PR1
YP_860532     5 TLLIHCPDTSGIIAAVTSFFHqrKGNIIYIDQYvdLENQTFFMRLECEFnhq--isFDDVKAHFKKDLgnpyKMSW 78  Gramella forsetii KT...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap