1U8S


Conserved Protein Domain Family
ACT_GcvR_2

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cd04869: ACT_GcvR_2 
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ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains
This CD includes the second of the two ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains. The glycine cleavage enzyme system in Escherichia coli provides one-carbon units for cellular methylation reactions. This enzyme system, encoded by the gcvTHP operon and lpd gene, catalyzes the cleavage of glycine into CO2 + NH3 and transfers a one-carbon unit to tetrahydrofolate, producing 5,10-methylenetetrahydrofolate. The gcvTHP operon is activated by the GcvA protein in response to glycine and repressed by a GcvA/GcvR interaction in the absence of glycine. It has been proposed that the co-activator glycine acts through a mechanism of de-repression by binding to GcvR and preventing GcvR from interacting with GcvA to block GcvA's activator function. Evidence also suggests that GcvR interacts directly with GcvA rather than binding to DNA to cause repression. Members of this CD belong to the superfamily of ACT regulatory domains.
Statistics
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PSSM-Id: 153141
View PSSM: cd04869
Aligned: 25 rows
Threshold Bit Score: 77.6467
Threshold Setting Gi: 50875669
Created: 18-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1U8S_B     95 EVYVESDDkLGLTEKFTQFFAQrQIGMASLSAQTIskdklhseqnQFHIAISARVDsgCNLMQLQEEFDALCTALDVQGS 174 Vibrio cholerae
YP_269881  93 RAEYSGIDqPGILKAMTAFFATrKIDISSLKSKIDpk------tnHMSANILFALTekISIDELEYDFLELCQQTDVQGF 166 Colwellia psychrer...
YP_131044  97 DFHIEADDtPGLIEQFTLFFATrKVDISSLSAHTVeaesd-dstnHFILQISTNLPedCNLMTLQEEYEALCLNLQVKGT 175 Photobacterium pro...
YP_205302  93 DAFIESEDrPGLTEKFTDFLANrDIDLKTLSAQTLkkse---nqnTFQIQITAEIFkeCHIIEIQEEFESLCASLNVSGK 169 Vibrio fischeri ES114
CAG35509   98 VMTVQSPNkKGLVHGVSQFCHAhKMNIIDLSTNLRn--------gIYTMALQLDLTksTGINAIEKDLARYNRDSGLQIV 169 Desulfotalea psych...
YP_436023  98 NVNVVALDhPGIVYRIAQFFYSrKINIDELQTNTYsaph--sgtqMFNINMTVNIPadMHLASLREEFMLFCDDLNLDAV 175 Hahella chejuensis...
AAM41031  125 IVEVIAADkPGILFQLADFFDRqGITIENLQSTRYramq--tgaeMFSAQVTIGVPanMHIAALRDDFLEFCDHLNLDAI 202 Xanthomonas campes...
YP_692495 103 EVEVVAMDnPGIVHEIAHFFSGrNINIDDLHTGTYaaph--tgtrMFSLHLTLSMNaeHSVAQLRDAFLDFCEARNLDAT 180 Alcanivorax borkum...
YP_113178  92 AVDVVAGEsGSHLYELADFFAArHIKILDVSTSRPpapy--tgtpMFIAHLTVMIPpaMKIIPLRDEFVEFCDRQNLDAI 169 Methylococcus caps...
NP_249700  99 VAYVSAVYrPDILNELCQFFIDhNIELENLTCDTYqaph--tnttMLNATITVTLPagTQISWLRDQFLDFADALNLDAL 176 Pseudomonas aerugi...
1U8S_B    175 LNF 177 Vibrio cholerae
YP_269881 167 IIK 169 Colwellia psychrerythraea 34H
YP_131044 176 VTF 178 Photobacterium profundum SS9
YP_205302 170 INF 172 Vibrio fischeri ES114
CAG35509  170 LQH 172 Desulfotalea psychrophila LSv54
YP_436023 176 LEP 178 Hahella chejuensis KCTC 2396
AAM41031  203 MDP 205 Xanthomonas campestris pv. campestris str. ATCC 33913
YP_692495 181 MTP 183 Alcanivorax borkumensis SK2
YP_113178 170 LEP 172 Methylococcus capsulatus str. Bath
NP_249700 177 IEP 179 Pseudomonas aeruginosa PAO1
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