Conserved Protein Domain Family
Peptidases_S8_Autotransporter_serine_protease_like

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cd04848: Peptidases_S8_Autotransporter_serine_protease_like 
Peptidase S8 family domain in Autotransporter serine proteases
Autotransporter serine proteases belong to Peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Autotransporters are a superfamily of outer membrane/secreted proteins of gram-negative bacteria. The presence of these subtilisin-like domains in these autotransporters are may enable them to be auto-catalytic and may also serve to allow them to act as a maturation protease cleaving other outer membrane proteins at the cell surface.
Statistics
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PSSM-Id: 173794
View PSSM: cd04848
Aligned: 48 rows
Threshold Bit Score: 140.537
Threshold Setting Gi: 126668008
Created: 6-Oct-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic triadputative active
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                                              #      
ZP_01223469    99 TGAGVTVGVIDSGVFeeHIEFAQGSGDKVEyagsyysi-------------------------gnprsddAISHGTLVAG 153  marine gamma ...
NP_602747      29 NGDKVKVGVLDGDFInkKNYLENKYGNIEIlern--------------------------------ynpkHSNHGELVLK 76   Fusobacterium...
NP_604320      34 NGSTVKIGILDSDFTdpVRKAQLSARYPGIefiprv-----------------------------nsdtsTSSHGVQVLE 84   Fusobacterium...
ZP_00144474    46 EGEGVKVAILDSDFQnaVRSSAKNEDGTAAivrrtralnvifpgtevdiipritsevrakdgtliattptTSQHGEEVLE 125  Fusobacterium...
ZP_02477735   383 TKFTNKIGIVDMDYNvrDDLGKAFKFENGSdriilnag------------------------lytranghKSSHGTMVAG 438  Haemophilus p...
ZP_02478919   194 EYSVQKIGVIDTDFVkdDKTFGNRLLLNQGlwrq--------------------------------akgqKHDHGSQVAA 241  Haemophilus p...
YP_001233597   90 TGTGVSIGILDTGANtgVQALQGRVAWFNSylaqgnntln---------------------qnniasandPYGHGSIVTA 148  Acidiphilium ...
AAM40596      106 TGAGYRIGVVDSGINgnHPALQGRLSDSFIyvdprdn---------------------------niavgdVVGHGTVVAE 158  Xanthomonas c...
NP_778548      93 TGKGYMIGVVDSGVNrnHVTLHDQVIHNNVyvdyqd----------------------------paspddVNGHGTNVAQ 144  Xylella fasti...
YP_001437000   77 NGAGIKVGVADTGILttHPALLGVVKGTLNyvdpsan---------------------------nlsvgdVRGHGTMVAQ 129  Enterobacter ...
Feature 1                                                                                         
ZP_01223469   154 IIAankdgadv----ssdfnmhGVAFDASILGYEiplgsgsgpydp--levdqinfsddNYFANRFNTMADQvDIINLSF 227  marine gamma ...
NP_602747      77 VLReknkl----------giiaGSIGENDDFSGKegttvi--------------pkletYEKVLEKFNPNQKvKVFSQSW 132  Fusobacterium...
NP_604320      85 VMMdtl--------------edRTKGKAKFKAIAasignggaset----nksvnpnvktYEKVFERFNFNQKvKVVNQSF 146  Fusobacterium...
ZP_00144474   126 VLRdmd--------------ssGGPYYNRIHTILgsfgldfydpdesknlfgavlankeTYDAALTRFGNQSvKIFNQSF 191  Fusobacterium...
ZP_02477735   439 VID-------------------QKNKNATLYAYTaksay---------------meavsASNQHYDEAYRHGvRIFNNSY 484  Haemophilus p...
ZP_02478919   242 VIA-------------------KYNSTSWIYGYTaess-----------------gmtsPSNLHFEAAQEQGiKIFNNSY 285  Haemophilus p...
YP_001233597  149 LLGgatqgtydntqgpvnffagGVAPDATLYVAQtcdat----------------gactLYGKTYQDLMANGvHLFNQSL 212  Acidiphilium ...
AAM40596      159 LAAggavg----------qwpgGIAPGATLVSARiiadkaptddg---sgqgneidgplGLEAVHADLIRAGtRIMNNSW 225  Xanthomonas c...
NP_778548     145 LIAgqpve----------ywpgGIAPGATIFSARvfssaaesakeg-piggnffegeaaQIKRVNADMIAAGvRIQNNSW 213  Xylella fasti...
YP_001437000  130 TLAgratg----------lftgGTAPGATLISARiipdva-------------ntrqslNFGQINYDLARAGaKIINNSW 186  Enterobacter ...
Feature 1                                                                                         
ZP_01223469   228 GFSgvvtsyta---------------tqvqsafgLTIDALAQQNKSLGeRSIFVFSAGNAWNdtdeqgntvdanspelmp 292  marine gamma ...
NP_602747     133 GVPetigsyiskseee------rmraiapgqtssEGRKILDFYKKEVNkDTLFIWANGNTLVnnqnqvvlfnd--ayyqg 204  Fusobacterium...
NP_604320     147 GADitieeapytkn----------nirnyvwagdSKPFATYFEEKVNNdGGLFVWAAGNRKGatetnpgqdmds-vgmea 215  Fusobacterium...
ZP_00144474   192 GGNkayddsslaqyrnegdslplyfnkvvgstapQVKQVPYFRDIVENkGGLFVWAAGNDAGknsslna----------- 260  Fusobacterium...
ZP_02477735   485 GNNphrdsvn-----------------gkgwkqlSDLHLYKQLAEMAErDSIFVWASGNDGRdkktgrseya----tieg 543  Haemophilus p...
ZP_02478919   286 GTApsnelvk-----------------yrgwtylTSHLLHKQIAEMAEnGSIFVWAVGNEGQlkgygaqav------tea 342  Haemophilus p...
YP_001233597  213 AENassfst--------------------asaaiQASQQIGALFAPFGtGNLYVWAAGNNPQspndisve---------a 263  Acidiphilium ...
AAM40596      226 GGLywtd------------------------pnvTNPVAQEYRAFVIGnDGLVVFASGNESRtepsdtaalps---qpgp 278  Xanthomonas c...
NP_778548     214 GYEsedtggep----------------vwrspitTGLFVNAYRDFVLNnNGLVVFASGNEAQpqpgqlsrlps---lptv 274  Xylella fasti...
YP_001437000  187 GIPdwnpt----------------------statTTYFVNAWKPFISSyNGLIVFASGNDGAanpvgvak---------l 235  Enterobacter ...
Feature 1                                                                                         
ZP_01223469   293 glpylfPELKDHMLAVAAVDdngeiafy---------------------------snrcgvaADYCLVAPGggdgngngn 345  marine gamma ...
NP_602747     205 glphlySELEKGWITVVGVKkkdgnmlnkhyt-------------------dtahlaypgnaKWWAISADAe-------- 257  Fusobacterium...
NP_604320     216 glpylvNDLEKGWIAVVGIQpketvrvgtapdgtpivnikpngklnihrtgtdrlayagdnaKYWSISADDs-------- 287  Fusobacterium...
ZP_00144474   261 glpyfeHRLEPGWISTVGVLdedngkyyvlgr------------------gnyelskagfeaKWWSISALMys------- 315  Fusobacterium...
ZP_02477735   544 hvpvirDGARKGWIVVTSINpqnsgvmey-------------------------asqigkdaKNWGIAAPGe-------- 590  Haemophilus p...
ZP_02478919   343 hipvayKQAKKGWIAVASITgqwkspys---------------------------srvgedaKNWGIATYGd-------- 387  Haemophilus p...
YP_001233597  264 eapaytNSLQPQWISAVNVDinslgqvsgl----------------------dptsnacgitAQWCIAAPGyd------- 314  Acidiphilium ...
AAM40596      279 ngtrpaADLERGWLVVGAVDtanptqlas-------------------------ysnacgvtMRYCLVAPGts------- 326  Xanthomonas c...
NP_778548     275 kgapsaADLERGWLVVAALDsldhpdqlt------------------------sysnhcgiaMHYCLAAPGdv------- 323  Xylella fasti...
YP_001437000  236 pslapaSGLDKGWLVATAVDtfnpsyias-------------------------yanrcgvmKNSCLAAPGsv------- 283  Enterobacter ...
Feature 1                                       #                                  
ZP_01223469   346 venleriWGPTkpdpeaevggyYYGGAIGTSFAAPVVSGSLALLKQMFptvgNHELTARLLTTAD 410  marine gamma proteobacterium...
NP_602747     258 -------VVDS-----------KGVTHRGSSFAAPRVAKVAALVAEKYdwmtADQVRQTLFTTTD 304  Fusobacterium nucleatum subs...
NP_604320     288 -------AIPT-----------AGRAGIGSSYAAPRVSRAAALVAEKFdwmtADQVRQTLFTTTD 334  Fusobacterium nucleatum subs...
ZP_00144474   316 ------aKNSQet-------dpNKKVGIGSSYAAPRVTMAAALVYEKYpwmtNDQIRQTLFTTTD 367  Fusobacterium nucleatum subs...
ZP_02477735   591 -------WYLFg----------DKVRTEGTSFATPVVTAAVANVWEKFdwmdHHLVTQTILSTAN 638  Haemophilus parasuis 29755
ZP_02478919   388 -------HQVF-----------GDRHVQGTSFAAPVVSAAVAKVWEKFpwmdNHLVTQTILSTAD 434  Haemophilus parasuis 29755
YP_001233597  315 ------qVPIVagt------sfNTGFAVGTSFSAPIITGVAALIWQKFpwftPANVSDTLLTTAT 367  Acidiphilium cryptum JF-5
AAM40596      327 ------vYVGPdsta----gnlSYFYGSGTSFAVPLVSGAAALVWQAYpyfnNDLVRQTLLGTAT 381  Xanthomonas campestris pv. c...
NP_778548     324 ------vVIHNsvtns-ssvddEYYKLQGTSFSAPLVSGAAALVWEAFpyfsNDLVRQTLLGTAT 381  Xylella fastidiosa Temecula1
YP_001437000  284 ------yVQSTdst-----gkpVLRLVSGTSFAAPQVSGVAAMVWQKYpyftNDLVRQTVLGTAT 337  Enterobacter sakazakii ATCC ...

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