Conserved Protein Domain Family
Peptidases_S8_Subtilisin_like_2

?
cd04847: Peptidases_S8_Subtilisin_like_2 
Peptidase S8 family domain in Subtilisin-like proteins
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
?
PSSM-Id: 173793
View PSSM: cd04847
Aligned: 89 rows
Threshold Bit Score: 148.606
Threshold Setting Gi: 110632872
Created: 6-Oct-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
active sitecatalytic triad
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                 #                                       
CAD31494     330 PVVGVIDAGVAAISQLepwrAGTAGLIspad-----rdeAHGSFIAGLLAGGGglnptiANRLEPTPCRFFDIDVLPrrg 404 Mesorhizobium loti
YP_361634    274 PRVAVFDGGTQNSFGAhvveLAAPGLPpatv-----adlAHGVNVTSALLFGPvd--psHTALSAPPWMVEHHRVLPtn- 345 Xanthomonas cam...
ZP_02327397  271 IKVGVFDGGINPTHPFlakfSKENKAVssnat---kegiKHGTAVAGVVLYGDlnqyeaNSHLDDPVLFVESFRVLPls- 346 Paenibacillus l...
YP_638634    315 PRIALLDGLPMAGHIAlserLIIDDPDqiaaty-tasqmQHGTAMASLICHGDln--apGASTQRRLYVRPVMQPHPfng 391 Mycobacterium s...
YP_642730    290 PRIALLDGLPFSNHAVlagrLVIDDPDrlgeny-plssrHHGTAMASLIIHGDls--vpGEPLDRPLYVRPIMCPHElaa 366 Mycobacterium s...
ZP_03712132  263 PRVALLDGLPVSNHGAlrgrLIIDDPDdlenhy-pvikrQHGTEMASLIIHGDln--kpDSPLDRPLYVRPIMESVEgig 339 Corynebacterium...
YP_734649    313 PRVALFDGLPLSNHSDlrgsLIIDDPDnfeagy-paqnrVHGTAMASLIVNGDlt--dgGSKLSTPLYVRPVMKPDPhtf 389 Shewanella sp. ...
YP_001679568 306 PVVALLDGLPLENHPLlsgrIIVDDPDgwasey-earerKHGTAMASLIINSDle--egKPPLNRRIYVRPILKPLGfeg 382 Heliobacterium ...
CAJ13778     307 PVIAVFDGLPLANHRLlngrLIVDDPDnvesty-nanerVHGTSMASLIVHGDln--dgLRPLGRPVYVRPIMQPIPndf 383 Desulfococcus m...
ZP_01076659  312 PIVALFDGLPLSNHEAlknrLIIDDPDdfealysspmeqVHGTSMASLIIHGDlnk-kdEPSLDRPLYVRPILAPGSphf 390 Marinomonas sp....
Feature 1                             #                       #                                  
CAD31494     405 l-----lgqyYQTPDEFFDQLETQIEVAKAEg------vRVFNMSLGAPGVRQGLGysSFAANLDRIALTHDVIFLVSAG 473 Mesorhizobium loti
YP_361634    346 --------dsPEQALDVLDRIVTALRIARTAdr----pyRFANISLGPVATFFDDDihEWTSRLDTELADGRTLCTAAVG 413 Xanthomonas cam...
ZP_02327397  347 --------dpKDFDLYEAIEFIEQVVPNRHDi-------DVYNLSFGPTGPIFDDEisRFTYALDTLAWNYQKLFVVAVG 411 Paenibacillus l...
YP_638634    392 de---etvlrDRLLVDLIHEAFRRMFERHGQhdpvapsvRIINLSIGDPIQMFVRRvsPLAKLLDWLAHTYNVLILVSAG 468 Mycobacterium s...
YP_642730    367 gs---eevlpNQLFTDLLHRAVRRIVEGESGrepaapsvRIINLSIGAQARALARRmsPVGRLLDWLAHTYNLLFVVSAG 443 Mycobacterium s...
ZP_03712132  340 ct---eqvisNVLFPDLLIRAVRRIMEGDGDseavapsvRIINLSIGDPARVLTRRmsPGGRVLDWLAVNYNLLFIVSAG 416 Corynebacterium...
YP_734649    390 nna--ealpdDELPLDIIHRAVKRIFEGDGAelpvapsiKVINLSIGDPNIHFDGKmsPFARLLDWLSSKYNVLFVVSAG 467 Shewanella sp. ...
YP_001679568 383 nra--eempiDCLPIDLVHRAIKRIFEGDGEegpqaprvKIINLSIADRNRPFDRVmsPWARLIDWLSWQYKVLILVSGG 460 Heliobacterium ...
CAJ13778     384 raprrehipdDVLLVDLIHRSVKRLFEGDGSegpvapsvRVINLSIGDPYRQFLQSmsPVARLLDWLSLTYGVLFIVSAG 463 Desulfococcus m...
ZP_01076659  391 dgmksekvpdNYLPIDLMHRAVIRMKVGDEGaqptapdvLVINLSVGDPYRRFDIQmsPWARMLDWLSYKYDVLFVVSAG 470 Marinomonas sp....
Feature 1        #                                                                               
CAD31494     474 NLRGRDARPEWSAtaedalemlat---------raiaeeritapGEHLFGITVGAINAPSVLGAVADVPTTytrr----- 539 Mesorhizobium loti
YP_361634    414 NNGALDGELGRIQp-----------------------------pGDAVNLFAIGAADTRHPKWNRAPYSATgp------- 457 Xanthomonas cam...
ZP_02327397  412 NDGEAPSPYNRVQa-----------------------------pADLVNGLGVGAYTFNYDTAERIRASYScig------ 456 Paenibacillus l...
YP_638634    469 NHAIDADIPAAALldtdelrravgta-----myekarqrrllspAEAVNVISVGALHADAASTPTSDTVLDttdtgmpa- 542 Mycobacterium s...
YP_642730    444 NHLDPITIPADSAndpavarvaatra-----vydatilrgilppGDALNVLTVGATHDDGLGEIDIPDTVWditqpgapa 518 Mycobacterium s...
ZP_03712132  417 NHNEIPITIPVEAlsniesartaavqa----tfnnslllgilspGDAINVLTIGATHNDKADAIKVPDTVLdvnranfpa 492 Corynebacterium...
YP_734649    468 NHPKAVTVQQLGStfhqftedvkaveff-kavqndtwarkllspAESVNAITVGSLHSDESSPVLRVGLYNiyseempa- 545 Shewanella sp. ...
YP_001679568 461 NQLDDLQIEGSRQelqrltaeeleekvl-qavvrqarqrrllspAEAINALTVGATHEDAVTHFEARRRINpivtqglps 539 Heliobacterium ...
CAJ13778     464 NQSDAIQLGISRTefessdpqeqetavv-kalfsdarnrkllspAESINGLTVGSVQYDSSHFGAVNNRFNpflqflps- 541 Desulfococcus m...
ZP_01076659  471 NMAQSICLEGIKErdfqslqlfnmeehfikaiakqkyerrmmspAESINALTIKAEHSDDFVGKLPPNQIDiletkkifs 550 Marinomonas sp....
Feature 1                                                                                   #    
CAD31494     540 -----gpgPGGARKPELAHIGGvspragssc---------------------------glhsigvdgQLVEGSGTSYATP 587 Mesorhizobium loti
YP_361634    458 ------grSPGFVKPDVLAFGGspaepmp-------------------------------vysplagGVVAVGGTSFASP 500 Xanthomonas cam...
ZP_02327397  457 -----dgrEGCKVKPDVCAFGGdsrypihl------------------------------inssdskEKLLSAGTSYSAP 501 Paenibacillus l...
YP_638634    543 lyspvgfgHRNSVKPEILLPGGrslhqrppvaegtttlypae-----ttitgpgmrvaapgrggslnGTTYLHGTSNATA 617 Mycobacterium s...
YP_642730    519 hygatgpgVDRSVKPDIHHVGGralytrpvaasgretveveia---rtaiagpgvqvavpgragatnTTVFTTGTSNATA 595 Mycobacterium s...
ZP_03712132  493 hysgrgpgINRSIKPDLYYMGGrvvykrpvitpeqqgnivleia--dssvvgpgvraavpsrggainGTKFCIGTSNAAA 570 Corynebacterium...
YP_734649    546 aysgqgngYARSVKPDISMPGGrmlyneaighsnltavsn----------yaapgqkvahphasafnHRVYIRGTSNSAA 615 Shewanella sp. ...
YP_001679568 540 pispvglgYRRAIKPDVLMPGGkqlyqepmmgqgtetplklls---fpgiapghkvacpgvqpgispSAAFLCGTSNATA 616 Heliobacterium ...
CAJ13778     542 pvsafgsgYRRAIKPDIVFPGGrvlyqedlrssrrdnyvikpvepsirntppgnksaiparqsgsleGIAYSCGTSNAAA 621 Desulfococcus m...
ZP_01076659  551 pinpislgKKNSIKPELMMPGGrltyrnksylaeqdivlepvv---strfgpgqktalpssvlgsvnSYGYTAGTSNAAA 627 Marinomonas sp....
Feature 1                                                    
CAD31494     588 LVTGSLAALDHRLegq-------------apRETLLALSVHKAE 618 Mesorhizobium loti
YP_361634    501 LALRTALGVDVLSqsr-------------fdPITLQALLINAAE 531 Xanthomonas campestris pv. vesicatoria str. 85-10
ZP_02327397  502 IISSKAAEILGRCsr--------------ftPLVARALLIHTAQ 531 Paenibacillus larvae subsp. larvae BRL-230010
YP_638634    618 MATRTADHIFDVLealqavdgeppfasaeyhPVLTKALLVHAAT 661 Mycobacterium sp. MCS
YP_642730    596 LVTREASRVFDTLeaavsgaedaplpdgqyhPLLVRALLAHASS 639 Mycobacterium sp. MCS
ZP_03712132  571 LVTHEASKLFDILeegnsenn---lpdalyhPLLVRALLVHASS 611 Corynebacterium matruchotii ATCC 33806
YP_734649    616 LISRGCAEVCDVLenlfeesnk-vgefeqysPLLLKSLITHGAS 658 Shewanella sp. MR-4
YP_001679568 617 LATRTTAQLYEYIvgvlrgeeggeqlqdrylAVLLKALFTHGAE 660 Heliobacterium modesticaldum Ice1
CAJ13778     622 LMSRAAGICYDSLqqifeeqaa-evdariheAPLLKAMLVHGCA 664 Desulfococcus multivorans
ZP_01076659  628 LATRRIAFLYETLkgikdlgds-ealshapdALILKALLAHGAE 670 Marinomonas sp. MED121

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap