Conserved Protein Domain Family
Peptidases_S8_11

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cd04843: Peptidases_S8_11 
Peptidase S8 family domain, uncharacterized subfamily 11
This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.
Statistics
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PSSM-Id: 173792
View PSSM: cd04843
Aligned: 18 rows
Threshold Bit Score: 294.991
Threshold Setting Gi: 159898738
Created: 9-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #                                       #               
YP_630202    237 GIDAKYAWTVLGgq---gQNVKVVDIEGGWRt-tHEDMPDLFHMGGTQyt--------dqSWRDHGTAVLGEIVGARNAY 304 Myxococcus xant...
ZP_01910797  227 PGVDVDAAWAIGlr---gEGIRLGDIEYGWNt-aHEDLVDQGVVPEPGqtpt-----pddNSLDHGTAVVGITSAGNNGY 297 Plesiocystis pa...
YP_564669    198 GIDALYAWTKTGgn---gQGVKIIDMENGFNs-nHEDLPTTFVRKYDY------------DDSDHGTAVLSVVGAKRDGK 261 Shewanella deni...
NP_827825    244 GIDAHWAWQRPGgs---gQDVTVIDVEGAWQl-gHEDLAAKLAGVVVGtpl------tdlAWRNHGTAVIGVIGGDRNER 313 Streptomyces av...
XP_001903120 183 GINALYAWGFPGgd---gANTTIIDIERGWKl-dHEDLVDANITLLAGlnvk----dryqSNYRHGTAVLGAMLMVDNNI 254 Podospora anser...
ZP_01443977  118 GIDARYGWTVPGgt---gAGVRIIDVEQGITp-dHEDLPPLVAETGPLn----------pQSSNHGSAVMGVLVGAENGY 183 Roseovarius sp....
YP_001544985 135 GIDAEAAWKVLEha---gKAITIVDIEKSWQl-eHPDLLQHGSSPITIlpsllhcdmhdpACADHGTNVLGVLVAQNNTE 210 Herpetosiphon a...
YP_001481095 191 GVNALNAHKHYPga--kgEGVTVMSNENGRWnndHIDLPRAIFSIGEDi----------aASRYHDTMSLGIMAGKDNDF 258 Serratia protea...
YP_001907222 189 GINAFAAHEKYPgstgkgITVLSNEIDRWDPe--HLDLPQPLFVLSYKp----------eKISAHDTMSVGIMAGKDNDF 256 Erwinia tasmani...
YP_002152439 152 GLGIIDAWNKNAy----gQGIQVADIEWDFDl-sHPDLLANNITPLFPlte-------ktDQADHGTAVAGLIMGKKDGK 219 Proteus mirabil...
Feature 1                                                                                        
YP_630202    305 GVTGIAHQAKAGYESig----------aqSTASAITRAataa----glgGIVLIELHARGPSDGTAcscntsq------- 363 Myxococcus xant...
ZP_01910797  298 GITGGVSEAQLHTFPelsv------eggsRRVAAILSAvsvf----epgDVLMYEMQIGGPNGPEAyi------------ 355 Plesiocystis pa...
YP_564669    262 GVTGIAYGAQLGFHGws-----------pSIAQAINNAagyl----sagDVIILEGQINRNINNGDsctsqnq------- 319 Shewanella deni...
NP_827825    314 GVTGIVPDAVTAAASfq----------giGTAAAIHAAadrl----gpgDVVLVELHRPGPRFDYEqrddqr-------- 371 Streptomyces av...
XP_001903120 255 GGVGIIPGAQGHVVGvtrvvg---ggpfeNYPEAILDAvdal----gfgDAILLEIQVPDANGNMFp------------- 314 Podospora anser...
ZP_01443977  184 GVTGIAHGAEAGFVShfg---------paTMAQAVLVAtllv----edgDIIVIEIQRRGPVNGQPclpgcnvctgtatt 250 Roseovarius sp....
YP_001544985 211 GGVGIAHDAAAAVISpwqkpsngtnqpswNIANAIVAAsnylttlelsgNLILLELQIYQDLAGGPytntpnq------- 283 Herpetosiphon a...
YP_001481095 259 GVLGIAHQSQFAYVAwq----------vsNFVDGINLLka--------gDVIQVGQQRLTSLIPAStcrsgn-------- 312 Serratia protea...
YP_001907222 257 GVTGIANQASFAYCDsp----------nkLFIEAVKRLkp--------gDVIQLGIQLGITTMPGCtqdc---------- 308 Erwinia tasmani...
YP_002152439 220 GITGLAYKLDMFYAIsel---------ssGRIEAIIASkqkl----hagDIVLYEMQTVCEHHAYVp------------- 273 Proteus mirabil...
Feature 1                                                                                        
YP_630202    364 ---cdyiamEYWQANYDAIKTATANGVIVVEAAGNGSADLDapayg-----------safnrNTRDSGAIFVGGSTattr 429 Myxococcus xant...
ZP_01910797  356 -------paEYAPAVHMATRTATDAGVLVVAAAGNGNQNLDapey-------------aeymAREDSGALIVGAGSstvq 415 Plesiocystis pa...
YP_564669    320 ---necvplEWNQATFDVISAVTNRGIIVIEAAGNGNENLDdpiyq-----------nrfnrNTRDSGAFLIAATNpsas 385 Shewanella deni...
NP_827825    372 ----gylalEWWPDDFAAIRYATAKGVIVVEAAGNGGESLDdaayerrpdefptwwrnpfnpSHRSSGAVLVGAGApppg 447 Streptomyces av...
XP_001903120 315 --------vEIIDAVFDAISLATSLGITVIEPAGNGQQDLDapilcigsat-pasilnpsspEFRDSGAIMVGAATstip 385 Podospora anser...
ZP_01443977  251 paqddsipiEFWQANFDAIQTATANGVIVVAAAGNGGSDLDdpvyn-----------gqfdrTVRDSGAIIVGAGDpvth 319 Roseovarius sp....
YP_001544985 284 --pgrllpvELEPANFEAIRLASELGIIVIEAAGNGASDLAtcwdtvgt-----yqiepetaRYRDSGAILVGAVYsrdp 356 Herpetosiphon a...
YP_001481095 313 ----cfvpvEIEQAWFDAIKTATDSGIHVIMAAGNGNVNLDhpvfq-----------grfdrSVRDSGAIIAGAVCgddg 377 Serratia protea...
YP_001907222 309 -----yapmEYSQSWFDAIKTATDSGIHVITAAGNGKLNLDhpsfn-----------gkfdrSKRDSGSVIAGAVDartg 372 Erwinia tasmani...
YP_002152439 274 --------aDYEMHIWEATRTLTEAGIIVIMAAGNGGVDLDlpfy-------------dsyrQRSDNHSIRVGAGSpytl 332 Proteus mirabil...
Feature 1                                                                         #              
YP_630202    430 l----------pmcwtNFGTRVDVHGWG--ERVYSMgygnvfga------sygedqfYTSSFSGTSSASPIVVGAAASAQ 491 Myxococcus xant...
ZP_01910797  416 ht---------kmgfsTYGSRVDIQGWG--TNVFTLgggtfeay------gddynqaYNGGFNGTSSAVPVVSNAVVVIS 478 Plesiocystis pa...
YP_564669    386 ia---------rsyfsNHGTRIDFNGWG--NEVAAAglygntlf------ngginqrYGDGFAGTSSASPIVAGAVAALQ 448 Shewanella deni...
NP_827825    448 thgrdhgpdrsrlafsNYGARVDAQGWG--REVTTTggfwdrpgdl--qggaeeivwYTDTFSGTSSASPMVVGALAALQ 523 Streptomyces av...
XP_001903120 386 rt---------rvlesNYGARIDVHAWG--ENILTAsvags-----------addidTYLPFDGTSGAAPIIAGAALSVQ 443 Podospora anser...
ZP_01443977  320 a----------pscftNYGDRIDLQGWG--RGVTTLgygglfdglgppsgpgllqqsYTANFSGTSSATPIVAGAAAAVQ 387 Roseovarius sp....
YP_001544985 357 nka-------trtassNYGQRVNCFAWG--NGVFTTna-----------------sgYSLSFGGTSAAAAIIAGAAILAQ 410 Herpetosiphon a...
YP_001481095 378 k----------kaifsTYGSRIDSASWGcwDIVTTTvdykanl-------waepnaqYTQAYSGTSAANPIIAGAAASLS 440 Serratia protea...
YP_001907222 373 e----------tawfsDYGSAVGSASWG--GDVTTTyangsgad-----lwdaphaqYTASFSGTSSANPIIAGAVAGLS 435 Erwinia tasmani...
YP_002152439 333 n----------rlpfsTHGSPIHVQAWG--EDVTTAgygdlfh--------gdgnnkYTANFSGTSSACALVAGAAAVIQ 392 Proteus mirabil...
Feature 1                                 
YP_630202    492 GVALAng-rrLTSTQMRSLLRANGT 515 Myxococcus xanthus DK 1622
ZP_01910797  479 QYAQQqg-vaLNGFGMRNLLVKTAI 502 Plesiocystis pacifica SIR-1
YP_564669    449 GFSKNakgqtLSVQTIKNILTATGV 473 Shewanella denitrificans OS217
NP_827825    524 GMLKAadqepMSPERARVLLRATGS 548 Streptomyces avermitilis MA-4680
XP_001903120 444 GMISAnrgtkLDALALRDLIKIDGT 468 Podospora anserina DSM 980
ZP_01443977  388 GAVLAaggdpLTSIEMREVLRAGAT 412 Roseovarius sp. HTCC2601
YP_001544985 411 AIGEQlrqarFSPEELRRLLTHPDA 435 Herpetosiphon aurantiacus ATCC 23779
YP_001481095 441 GIAKQyg-rlLTPRHLRKLLTETGT 464 Serratia proteamaculans 568
YP_001907222 436 GIAKQhg-vtISPKEMRELLTETGT 459 Erwinia tasmaniensis Et1/99
YP_002152439 393 SWYKDktntvLTPIEMRELLIKTGT 417 Proteus mirabilis HI4320

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