1WMD


Conserved Protein Domain Family
Peptidases_S8_Kp43_protease

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cd04842: Peptidases_S8_Kp43_protease 
Click on image for an interactive view with Cn3D
Peptidase S8 family domain in Kp43 proteases
Kp43 proteases are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Kp43 is topologically similar to kexin and furin both of which are proprotein convertases, but differ in amino acids sequence and the position of its C-terminal barrel. Kp43 has 3 Ca2+ binding sites that differ from the corresponding sites in the other known subtilisin-like proteases. KP-43 protease is known to be an oxidation-resistant protease when compared with the other subtilisin-like proteases
Statistics
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PSSM-Id: 173791
View PSSM: cd04842
Aligned: 63 rows
Threshold Bit Score: 167.122
Threshold Setting Gi: 163846300
Created: 9-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic triad
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                                               #                 
1WMD_A         16 SYGLYGQGQIVAVADTGLDTGrndssm-------heafrgKITALYALGrtnna---ndtnGHGTHVAGSVLGNGst--- 82   Bacillus sp. ...
ZP_02183595   110 GLNLNGDGIQIGHWEAGGLALtthq-----------efngRVTHAEFELv----------tSHATHTACTLIGTGvdn-- 166  Flavobacteria...
YP_001634344  234 NPASAPGSIVIGVWDCGWVESnhpa------------fsgRLTIGDPDSftngcgdvagtdYHATHVAGTAAGSGagsps 301  Chloroflexus ...
ZP_01203072   193 GRNYTGAGIGVLVRDDGIVGPhid-------------fegRIDNTQATGtg---------qTHGDGVAGILAGAGnlnp- 249  Flavobacteria...
ZP_03735238   274 LGIDGGSGVKVAICDSGVDTNdknnktg------hrdllgRQNSFLDYGdgdyc---pedlAHGTHVASIAVGSAgtgqk 344  Dethiobacter ...
YP_001547178  309 LPNNPAEYPIVDVVDDGFDDGtinplhpdfylngvrpgtsRITATSNCTldprg---nslaGHGQINAGIIGGYNnlt-- 383  Herpetosiphon...
ZP_01891639   225 GRNYTGAGIGVMVRDYGPVENhad-------------fkgRLVNDTNGLen---------lNHGENVAGIFAGAGninp- 281  unidentified ...
ZP_01687175   108 YPQFNGDGLFVSVREDPFNKTdid-------------fagRIADTANVGkt--------vdTHASIIASVIAGGGnsss- 165  Microscilla m...
ZP_01691796   114 FPALTGEGMLVSLHEPLFNTNdidlrg--------rfiskGTEAIYDFAk----------aDHPTNMATFIAGAGnsss- 174  Microscilla m...
YP_001196569  183 FPLLRGEDQTAVIKDDFFDVNdvd-------------ilnKHIASTTQSav--------vsNHATAMATIVCGLGnssv- 240  Flavobacteriu...
Feature 1                                                                                     ####
1WMD_A         83 -------nkGMAPQANLVFQSimdsggg------------------lgglpsnLQTLFSQAYSag-----aRIHTNSWGA 132  Bacillus sp. ...
ZP_02183595   167 ------darGMASSATIVSRR--------------------------------SNNDESEIANfga--aggILSNHSYST 206  Flavobacteria...
YP_001634344  302 ----grdlrGHADQATVLSYDv-------------------------------YDVDLEVMQAiqd--ydlDISQNSWGP 344  Chloroflexus ...
ZP_01203072   250 ------enrGMAAGSNVYVSNyas--------------------------sflDGTTTSLIANgn-----vQITNSSYGN 292  Flavobacteria...
ZP_03735238   345 dgdgfywgqGVAPRAEYVNQNillgp-----------------------wppdWQKLVRDAAVkg-----aQVMNNSWCS 396  Dethiobacter ...
YP_001547178  384 -------gfPYIDEASSGIAGgyniglgiapytrmsstkifrnsgsfsisncdGGDSYADIVTagye-hqaAITSNSWGQ 455  Herpetosiphon...
ZP_01891639   282 ------imrGMAAGADIYNVDstq--------------------------dfmDTQTTSLLYDgt-----vQITNTSSGF 324  unidentified ...
ZP_01687175   166 ------salGVAWKAQLYSSG--------------------------------FRNGLAPDNGntlmrqkaYVQNHSYGV 207  Microscilla m...
ZP_01691796   175 ------rgkGVAWKANLTSSNnadt-------------------------lpeSDTYYQNTGI--------IAQNHSYGL 215  Microscilla m...
YP_001196569  241 ------lgkGVAQKARLVSSDf-------------------------------MNIYPDEIETlq----gaTTSNHSYGT 279  Flavobacteriu...
Feature 1                                                   #####                                 
1WMD_A        133 Avng--------aytTDSRNVDDYVRk--------nDMTILFAAGNEGPnggt--------------isaPGTAKNAITV 182  Bacillus sp. ...
ZP_02183595   207 Gnpngdip-vygvytNNSKEWDEILYna-------pYLTLCKSAGNDRNdgentvdn------gydliytVSTSKNLITV 272  Flavobacteria...
YP_001634344  345 DtggicdltvlgvydEFAAMFDALVHgtyst-eitkQIAVAFANGNEQSycpngw----------rtgsgGAMGKNVIAV 413  Chloroflexus ...
ZP_01203072   293 Gcna--------gytITANTVDSQINnt-------pTLLHVFSAGNSNGsdcgygagg----qwgnitggHKQGKNVIAT 353  Flavobacteria...
ZP_03735238   397 Gkapg------dgytLPARTFDRLIRdavpgtarprGLAVIFSAGNAGPgsfs--------------itpPKELKNAIVV 456  Dethiobacter ...
YP_001547178  456 Pgsmg-------aynIYSQLYDQLTRdassddagnqAMLHIFAAGNMGEfgan-------------tvsaPSTAKNVISV 515  Herpetosiphon...
ZP_01891639   325 Lcqn--------gytLNAVTLDQQANdl-------pSLLHVLSAGNANNfdcdygagd----qwgnlggaNKTSKNNIAA 385  unidentified ...
ZP_01687175   208 Gaien-------yygIEAEAYDQHGIdf-------pQLLHVFSIGNFGNqtataahtkynikgfanlsgqFKVAKNVLTV 273  Microscilla m...
ZP_01691796   216 Kgqvn------nvydDKARAFDLSANnn-------dQLLHVVSSGNDGTigptegnykg-vvgyanlsgsFKMAKNILHV 281  Microscilla m...
YP_001196569  280 Iien--------fygSLASAYDDQLFln-------tDLTHCFSSGNTGLegyks------------itgnFKQSKNSIVM 332  Flavobacteriu...
Feature 1                                                                                         
1WMD_A        183 GATENlrpsfgsya--------dninhvaqFSSRGPTKDGRIKPDVMAPgtFILSarsslap----------dssfwaNH 244  Bacillus sp. ...
ZP_02183595   273 GAVNDvsaysgp-----------qsitqsaFSNWGPTDDWRIKPDIIANgvSVYSad--------------------dDS 321  Flavobacteria...
YP_001634344  414 GATNSddks------------------mtdFSSFGPTEDGRVNPTVVAPgcEAGGegaiw--------------stlpGP 461  Chloroflexus ...
ZP_01203072   354 ANVNDdgs-------------------lagSSSNGPATDGRIKPDITAHgqGHISt----------------------DE 392  Flavobacteria...
ZP_03735238   457 GNSLNynpdkrfrc--------kdirgvfgASSRGPARDGRILPTVVAPgtDVAAalsqgsrrtp----ivgsgdkvhRS 524  Dethiobacter ...
YP_001547178  516 GATENvrdegvldgngceisqadnaddlavFSGKGPTDDSRIKPDIMAPgtHVIGpapqesgflgagvcggltnpyypDN 595  Herpetosiphon...
ZP_01891639   386 ANVTFdgt-------------------ivgTSSRGPAADGRIKPDLSAMgdGQWTt----------------------NE 424  unidentified ...
ZP_01687175   274 GEIDTnsv-------------------vttLSSRGPAYDGRIKPELVAYggGNGSsesaai-----------vsgiglLA 323  Microscilla m...
ZP_01691796   282 GAISAnkq-------------------llpFSSKGPAYDGRIKPELVAYggNGGDfsgtsnaa-------aittgmvtLL 335  Microscilla m...
YP_001196569  333 GCVDQnev-------------------impFSSKGPAYDGRIKPELVAFstQGTSnstala------------tgiitLM 381  Flavobacteriu...
Feature 1                   #                                                                     
1WMD_A        245 DSKYAYMGGTSMATPIVAGNVAQLREHFVKnrgi----------------------------------------tpkPSL 284  Bacillus sp. ...
ZP_02183595   322 DTDYTTKSGTSMSTPSVTGAIALLQQHYHNengv----------------------------------------ymkAAT 361  Flavobacteria...
YP_001634344  462 TYGANGWCGTSMATPAVSGILGLMLEAYNLtyns----------------------------------------dplPAT 501  Chloroflexus ...
ZP_01203072   393 DNGYLSFGGTSGAAPGVAGVAAQLYDAYQTlang---------------------------------------nlpeSAL 433  Flavobacteria...
ZP_03735238   525 TNRYVYMTGTSMSAPLISGACALLIEWWRRrtgg---------------------------------------kdpsPAM 565  Dethiobacter ...
YP_001547178  596 QTLYTWSSGTSHSAPAVSGAASLLYTKYRTsfgng--------------------------------------atpsPAM 637  Herpetosiphon...
ZP_01891639   425 GGGYNAFGGTSAAAPSIAGVAAQLYEAYGDyngg---------------------------------------alpqSAL 465  unidentified ...
ZP_01687175   324 QQAYQNKKGQIPPAALLKAVLINAADDLGRtgidfeygfgsvdalgtiktlednryftetlaatndsktfkitvpahAQH 403  Microscilla m...
ZP_01691796   336 QQAYQQQKGQFPSATLLRAVLINSAEDVATtgvdfktgygninvyrahqnlia-eqyvtgtatqgntasfdmnvpanATH 414  Microscilla m...
YP_001196569  382 KQHYKNIHNKTLSNAATKAILINSAKDLGStgpdftygygninadkclktise-nriisdsltsaqtnahtinvpenAKN 460  Flavobacteriu...
Feature 1                   
1WMD_A        285 LKAALIAGAA 294  Bacillus sp. KSM-KP43
ZP_02183595   362 VKALLLGTTD 371  Flavobacteriales bacterium ALC-1
YP_001634344  502 LRAILVHTAE 511  Chloroflexus aurantiacus J-10-fl
ZP_01203072   434 IKAIMLNTAN 443  Flavobacteria bacterium BBFL7
ZP_03735238   566 LKALLINGAE 575  Dethiobacter alkaliphilus AHT 1
YP_001547178  638 LKAYLLASSR 647  Herpetosiphon aurantiacus ATCC 23779
ZP_01891639   466 IKAAMLNTTN 475  unidentified eubacterium SCB49
ZP_01687175   404 LKVTLVWHDP 413  Microscilla marina ATCC 23134
ZP_01691796   415 LKITLVWNDP 424  Microscilla marina ATCC 23134
YP_001196569  461 LKITLVWNDL 470  Flavobacterium johnsoniae UW101

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