Conserved Protein Domain Family
HTH_NolA-AlbR

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cd04788: HTH_NolA-AlbR 
Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR
Helix-turn-helix (HTH) transcription regulators NolA and AlbR, N-terminal domain. In Bradyrhizobium (Arachis) sp. NC92, NolA is required for efficient nodulation of host plants. In Xanthomonas albilineans, AlbR regulates the expression of the pathotoxin, albicidin. These proteins are putatively comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133415
View PSSM: cd04788
Aligned: 8 rows
Threshold Bit Score: 127.879
Threshold Setting Gi: 21218949
Created: 25-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
AAB06564     11 WRIGELAGATGVTVRTLHHYEHTGLLaASERTDgGHRMYDrESIQRVHQIRALRELGFSLQEIRRAMDgrt-----sltD 85  Bradyrhizobium sp.
BAC91598      6 WKVGELARQTGLSVRTLHYYDEISLLsPSHYTEgGHRLYCtGDIARLQQIKSLRQLGFSLDEIRTSLErsdc----splE 81  Gloeobacter viol...
ZP_00421607   3 LKVGELAKRSGLTVRTLHHYHAIGLLaPSARADnGYRLYDrDDIARLHQIQALRRFGLSLAEIGDYLNqpgt----plvE 78  Burkholderia vie...
YP_373420    12 LKIGDLAKRAGLSVRALHHYDAIGLLsPSQRTDgGARLYGrDDLVRLHRIEALKRFGYSLPDIKASLDgqla---gsplA 88  Burkholderia sp....
YP_076013     6 WKIGELARRVGITVRTLHHYDHIGLLsPSSSTEaGHRVYSdADVRRLLSIISLKRLGFSLREIKVLLSdaae----dprA 81  Symbiobacterium ...
NP_630079     9 RHIGALARETGLSIRTLRYYDRLGLLtPSARTEgGHRCYDaGDVRRLHRVLALRSFGLPLARIRAVLDaepd---hdpaE 85  Streptomyces coe...
NP_624728     1 MLIGEVARRSGVSARMLRHYESLGLVrPSGRTGsGYREYSrADIRRIFHIESLRSLGLSLREIGRALDepgfapaalvdD 80  Streptomyces coe...
YP_517382     6 MKIGDLADLFGVTVRTLHYYHQIGLLiPSQTTAsGHRLYNeNDVKRLYQIITLKNFGFSLEEIGKMTSstdp----dplV 81  Desulfitobacteri...
Feature 1                           
AAB06564     86 LLRKHLQRIEVQVARATQLR 105 Bradyrhizobium sp.
BAC91598     82 VLQRHIAHVKEQIELQQRLC 101 Gloeobacter violaceus PCC 7421
ZP_00421607  79 LVAKQIASLERQLAQAAQLR 98  Burkholderia vietnamiensis G4
YP_373420    89 LLQRQIAELDAQASRAQRLG 108 Burkholderia sp. 383
YP_076013    82 MLQVQLARLDEQIAALTEVR 101 Symbiobacterium thermophilum IAM 14863
NP_630079    86 LIRRQLDVVEERLRQTAELR 105 Streptomyces coelicolor A3(2)
NP_624728    81 LIRRTRERIAAETELLTRLR 100 Streptomyces coelicolor A3(2)
YP_517382    82 LINLQVQKAAEALEFQQALY 101 Desulfitobacterium hafniense Y51

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