Conserved Protein Domain Family
HTH_HMRTR_unk

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cd04787: HTH_HMRTR_unk 
Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators
Putative helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR), unknown subgroup. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules, such as, metal ions, drugs, and organic substrates. This subgroup lacks one of the conserved, metal-binding cysteines seen in the MerR1 group.
Statistics
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PSSM-Id: 133414
View PSSM: cd04787
Aligned: 13 rows
Threshold Bit Score: 194.444
Threshold Setting Gi: 110593482
Created: 19-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingdimer interface
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                 ###                                          
ZP_00816383   1 MKVKEIATAAGVNPDTVRFYTREGLLR-PTRNPdNNYQQYDaEDLRRLRFARKARQLGFSLPEIRQILEQAddHHSPCPM 79  Marinobacter aqu...
YP_437785     6 LKVSEMAKRSGVTADTVRFYTKQGLLQ-PTRDPdNGYQLYDrDDLQKLIFAKKARQLGFSVKEINQIMAQAedHHSPCPM 84  Hahella chejuens...
YP_575048     1 MKVSDLARAAGVTGETVRHYTREGLLH-PRRDPgNGYQLYDpDDLNRLRFIQRARTLGFSLREVREILEHAdhGDSPCPM 79  Chromohalobacter...
ZP_00816782  21 MKVNEIANLADVSPDTVRFYNREGLLR-PRKDPrNGYNLYNsEDLWRLRFVRVANKLGFNLREVKVILSHGteGGLAGSD 99  Marinobacter aqu...
ZP_00837970   1 MRVNQLAKNLNITGDTVRFYTRIGLLS-PAKSSvNGYKDYSdKDQSRMQFILSARNLGFSVDEIKVIFSRTdqGESACGL 79  Shewanella sp. PV-4
YP_527406     1 MRVKELANHLSVSAETVRFYTRQGFLS-PTKNPvNGYKEYGlKDQSRLRFILSARALGFTVKDIAEILSVAeqKRTPCPM 79  Saccharophagus d...
ZP_01101458  30 VKVIEMARRLGVTADTVRFYTRIKILK-PGKNKaNGYREYSeKDYNRLRFVLSARQLGFSVEDIQEILNHAdkKKSPCPT 108 Congregibacter l...
ZP_01109928   1 MKVREIASALATTPDTVRYYTRLQLIT-PAKSD-NGYKFYStKDASRLRFILSARHLGFSVEDIKQILREAdnGKTACPL 78  Alteromonas macl...
YP_339531     1 MYVKQLANKMSVTPDTIRHYTRMQLLK-PVRSVsNGYQEYTkTDQQRLKFIINARQLGFSVKDIQHIITESeqGNCPCPL 79  Pseudoalteromona...
ZP_01109886   1 MRVKQIADALEISADSVRYYTRIGFLV-PSKSH-NGYKYYRpADVTRLRFILSARSLGFSINDIKEILFTSsqTNAPCPT 78  Alteromonas macl...
ZP_01451716   2 MTVKGLATAVNVTPDTVRYYVRTGLLR-PVRDPvNGYRRFSmLDVDRLRFICRAKSLGFTLAEITDVFADAeaGDSPCPR 80  Mariprofundus fe...
ZP_01381834   1 MQLIECAREAGVTPDTLRHYLRVGLLVpDGRGA-NGYRAFSeRSVARVRFIRNALALGFTLKDAAEFVEMSqrGTSPCPR 79  Acidovorax sp. JS42
YP_693125     1 MRVSELAKQAKTTAETVRHYTNIGLLS-PSRDShNGYRYYRaEDLRLLRFALKARSLGFTLSDIQSLIHASreGETPCGQ 79  Alcanivorax bork...
Feature 1                                                                           
ZP_00816383  80 VRDVFQQRLAEVEREISELQKLRARMVSALSTWQEMPDGTPDGHt--------------ICRLIEHWD 133 Marinobacter aquaeolei VT8
YP_437785    85 VRRLFEEKFAEVERQIAELTQLKTRMQEAMSAWEHMPDGDPNGHt--------------ICRLIEHWE 138 Hahella chejuensis KCTC 2396
YP_575048    80 VRDLLAARLPDIHARIRELQALATRMERALETWRDMPDGTPDGHs--------------LCRLIESLP 133 Chromohalobacter salexigens ...
ZP_00816782 100 LKELFTDRLCRLDQELKELKRLRDDMKTTVQVWRQMPDGAPNGHsvqefsraptsvyayIFGLKISER 167 Marinobacter aquaeolei VT8
ZP_00837970  80 VRQMIQQKLEETEKQFEEMVKLRRKLSNAVEDWSHKPDKAPTGNm--------------ICHLIEGTY 133 Shewanella sp. PV-4
YP_527406    80 VRMMIEKRLLETEAQYQETVKLRQRMREAVKTWSGLPDAEPTGDm--------------ICHLIESFS 133 Saccharophagus degradans 2-40
ZP_01101458 109 VRRLIDQRLHETERQLRETLKLRDRMQQAVLEWSQKPDKAPTGHm--------------LCHLIEEFT 162 Congregibacter litoralis KT71
ZP_01109928  79 VRTLIARRLAETERQFKAMLLLRQNMMLAVRKWGAMGDKAPSSHv--------------VCHLIEEFE 132 Alteromonas macleodii 'Deep ...
YP_339531    80 TRKLIVKRLAETEALFQETLKLRTRMQAAVKQWQSSPDGATSAD---------------ICSLIESFV 132 Pseudoalteromonas haloplankt...
ZP_01109886  79 VRRLIEQRLKETEQRYQDMHELRLRMRKAISEWENTPDQHPTADt--------------ICHLIEGFT 132 Alteromonas macleodii 'Deep ...
ZP_01451716  81 VRAIIRRRIEENRQRIDELLALQDRMELADSQWQSMEDGMPDEGs--------------ICRLIDAMD 134 Mariprofundus ferrooxydans PV-1
ZP_01381834  80 ARALLSERLDEQARRLKEATELHLRMQQADRDWTRLPDGVPDGHs--------------VCSLIEGAA 133 Acidovorax sp. JS42
YP_693125    80 VRTLIEDRLNQVETRITELQALSDRMRDAMEQWQGAPDCRLDDGr--------------VCGLIDSFV 133 Alcanivorax borkumensis SK2

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