Conserved Protein Domain Family
HTH_CadR-PbrR-like

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cd04785: HTH_CadR-PbrR-like 
Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators
Helix-turn-helix (HTH) CadR- and PbrR-like transcription regulators. CadR and PbrR regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which comprise a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133412
View PSSM: cd04785
Aligned: 39 rows
Threshold Bit Score: 145.768
Threshold Setting Gi: 103488040
Created: 19-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
YP_616043     1 MKIGELSRATGTNIETIRYYERIGLLPaPARTAgNYRSYGDAHRARLRFVRHSRELGFTIEEIRSLLDLsddpardCGEA 80  Sphingopyxis ala...
ZP_00053716   6 FNIGRLGERAGVNIETIRYYEKIGLLPePGRTAaGYRQYGEDHLRRLSFIRKGRDLGFSIEAIRALLRLaehpeqpCEDA 85  Magnetospirillum...
ZP_01001232   4 LRRGDLAKLTGCNLETIRYYENIGVMPePPRSSkNYRVYDDRHVARLRFIMRARELGFTLDEVRDLLALvdggaqtCGEV 83  Oceanicola batse...
YP_757555     3 ITRGKLAKLTGCHLETVRYYESIGLMPePARAAnGFRTYSDDDVRRLQFLMRARDLGFAVAEVQNLLSLvdnnaysCGQV 82  Maricaulis maris...
ZP_01104895   8 LSRGTLAKRSGVNSETVRYYEKISLLPePVRSAgGHRVYREDDLQRLCFIRRCREMGFSLEEIRGLLSLvdrqqvsCKRV 87  Congregibacter l...
ZP_01018337  10 LKRAELAGRLGCNLETIRYYEKIGLLPePARTAsGHRLYSNEDQVRLRFILRARSLGFSVEDVRSLLGIndg-rpsCAEV 88  Parvularcula ber...
YP_756326     5 LKRGAVAKLLDCNIETIRYYESIDLVAaSARSDaGHRLFSQADVERLRFALRLRQLGFALAEVRELLTMtekqtfsCKQV 84  Maricaulis maris...
ZP_01439115   7 FGIGELSRRTAVNIETIRYYERIGLLPsPPRTEgGHRLYSEAHRKRLVFIRRSRELGFTIDEIHNLLGLveg-gytCGEV 85  Fulvimarina pela...
ZP_00052637   6 FNIGGLSRQTGVNIETIRYYEKIGMLPpPARSQgGFRQYEDHHIQRLRFIRRGRDLGFSIDSIRALLTLaerpdspCEGA 85  Magnetospirillum...
YP_617601     6 IAIGELSRQTGCNIETIRYYERIGLTPrASRRG-RYRSYDTADIRRLRFIRRARELGFTLEEISALIGIaaagevsCANA 84  Sphingopyxis ala...
Feature 1                                                     
YP_616043    81 DRIATRHLNQVEAKIAQLTLLRDELKRIVgRCRGGvaADCRVIEAL 126 Sphingopyxis alaskensis RB2256
ZP_00053716  86 DRLASAHLAEVERKIEELGRLRDALSEMA-HCCAGtvAECRIIDAL 130 Magnetospirillum magnetotacticum MS-1
ZP_01001232  84 QGLANAHLASVRAKIADLKRIEHVLSSTVaQCSGDdvPECPVIDAL 129 Oceanicola batsensis HTCC2597
YP_757555    83 RDITLDHLASVRKKIADLKRLESVLGDMAsQCDGGvvPECPIVDAL 128 Maricaulis maris MCS10
ZP_01104895  88 KSIADEHLRDIRTKISDLKKMEKTLRTLSaSCSGEdvPECPIIESL 133 Congregibacter litoralis KT71
ZP_01018337  89 RALAEAHRGDIRKRIADLKQMDRRLGEIMaGCTGAetPDCALTDKL 134 Parvularcula bermudensis HTCC2503
YP_756326    85 AGIAEMHLSQIHRKVADLRQLAASLEEITsQCQRTdtPDCALVLSL 130 Maricaulis maris MCS10
ZP_01439115  86 QAVALDHLKHIRRKITDLRRMERTLADTAaRCAGGtsPDCPIVDVL 131 Fulvimarina pelagi HTCC2506
ZP_00052637  86 DQMVLLHLDEVERKIADLTLLRDELRKMK-NCCGQvvAQCQIIGSL 130 Magnetospirillum magnetotacticum MS-1
YP_617601    85 RGIAAAHLASVRARLLDLRRMEEVLHGVVrACDAGehAGCPLIETL 130 Sphingopyxis alaskensis RB2256

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