Conserved Protein Domain Family
HTH_CadR-PbrR

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cd04784: HTH_CadR-PbrR 
Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators
Helix-turn-helix (HTH) CadR and PbrR transcription regulators including Pseudomonas aeruginosa CadR and Ralstonia metallidurans PbrR that regulate expression of the cadmium and lead resistance operons, respectively. These proteins are comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains have three conserved cysteines which form a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133411
View PSSM: cd04784
Aligned: 36 rows
Threshold Bit Score: 161.199
Threshold Setting Gi: 42630863
Created: 19-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
AAK48830      1 MKIGELAKATDCAVETIRYYEREQLLPePARSDGNYRLYTQAHVERLTFIRNCRTLDMTLDEIRSLLRLRDSPDdsCGSV 80  Pseudomonas putida
ZP_01402887   5 MRIGELGRATGVDIETIRYYEKIGLLPaPARSDNGYRSYAQPHLERLAFIRHCRALDISLADVKRLLDFAAQPGadCGDI 84  Verminephrobacte...
NP_900823     1 MLIGELARQTGCEVETIRYYEREGLLSaPQRSASGYRRYTAEQLGELNFILHCRSLGMSLADIRNLAAFKADHEhdCEDI 80  Chromobacterium ...
YP_048059    41 YLIGELSKKSHISVDSIRFYEKRGLLQaPQRAPNNYRYYDDQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEqqCNVI 120 Acinetobacter sp...
NP_246880     5 FKIKQASEQTGVHLETIRYYEKQGLIA-PTHQQNGYRVFDENQLEQLRFIKTCRNIGLSLSNIKTLLQLQQTPNkqCNEI 83  Pasteurella mult...
YP_088625     3 MKINELSKKSGINLETIRYYEKTGLLPePKRAANGYRVYDQQSLSQLNFIKSCRWLGFSIDEIKQLNELKNTPKh-HCVA 81  Mannheimia succi...
ZP_00156402   1 MKISELSKSTHTNIETIRYYEKQGVLQpPKRLANGYRYYDEESVEQLKFIKKCRTLGFSLENIKVLNRIKFSMEd-HYQA 79  Haemophilus infl...
YP_268685     1 MKINQLSKLTNVLSKTIRYYEDVGLLPkASRNSNGYREYRSSDVDNLIFIRRCRELQIPLEKIKILIQVQTDTSssCSEV 80  Colwellia psychr...
YP_662430     1 MQIKQLAQVTNVSAKTIRYYEDIGLLPeAKRGENGYRYYQQTDVSSLNFIRRCKELRMPLADIKRLVAVQSDGNapCAEV 80  Pseudoalteromona...
YP_339105     1 MQIKQLAHLVNINAKTIRYYEQINLIPaPKRESNGYRTYTQADTERLIFIRRCRDLQIPIDDIKTLLVAQSYGDksCVEV 80  Pseudoalteromona...
Feature 1                                                      
AAK48830     81 NALIDEHIEHVQARIDGLVALQEQLVELRrRCNAQg--aECAILQQL 125 Pseudomonas putida
ZP_01402887  85 DRLIDAQLARARARLKSMRALERQLAALRaRCHPGqvtgECGILHEL 131 Verminephrobacter eiseniae EF01-2
NP_900823    81 NLLIDQQIAKVHQQVEALRLLEQQLLALRdKCHDShaaaDCGILQTL 127 Chromobacterium violaceum ATCC 12472
YP_048059   121 DQAIEEHLEHINQKIRQFETFKIQLEQLReRCQSNstidHCKIVQTL 167 Acinetobacter sp. ADP1
NP_246880    84 NALAEQHLAYLDEQITELQQVKTFLMQFV-GCENKtv-dKCQIIQGI 128 Pasteurella multocida subsp. multocida str. Pm70
YP_088625    82 DEMILSHLKQVEEKIARLLEIQTFLQNLVnHEEHSv--eECRAISGL 126 Mannheimia succiniciproducens MBEL55E
ZP_00156402  80 DQLVLNQLIQVENKISQLLEIKDFLQSIVtESEHNe--eECKAIEGL 124 Haemophilus influenzae R2866
YP_268685    81 DLLIKQQLENVRETINELSLLEKTLHTLAkSCSNDiv-gECEILKNL 126 Colwellia psychrerythraea 34H
YP_662430    81 DALIAQQLEQIRVAQYELQQLEKNLQALAdSCQHGqi-kNCDILNHL 126 Pseudoalteromonas atlantica T6c
YP_339105    81 DDIIENQLIKVRAAQKELKKLEVSLASLLtNCTANti-nDCQIIKEL 126 Pseudoalteromonas haloplanktis TAC125

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