Conserved Protein Domain Family
HTH_BltR

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cd04782: HTH_BltR 
Helix-Turn-Helix DNA binding domain of the BltR transcription regulator
Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BltR (BmrR-like transporter) of Bacillus subtilis, and related proteins; N-terminal domain. Blt, like Bmr, is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. These regulators are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133409
View PSSM: cd04782
Aligned: 15 rows
Threshold Bit Score: 119.257
Threshold Setting Gi: 18309747
Created: 25-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingdimer interface
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                 ###                                          
BAA12356      9 FTTGEFSKLCRVKKQTLFHYDEIGLFsPEIKKE-NGYRYYSyHQFETFQVISLFKeLGVPLKEIKCLIKgktpdkilHVL 87  Bacillus subtilis
ZP_01361267   9 LTTGEFAKLCSIPKHILFHYDQIGLFqPEIIKE-NGYRYYSfRQYDTFSIIVALKqLGMPLKEIKKFMDernpsaliSLL 87  Clostridium sp. ...
ZP_01354636  14 FTTGEFAKRFGIKKDTLFYYDRIGLFhPAKVGD-NDYRYYTfEQLDVFWMLQSLReLNFPIKSLKNYVNdpspqkliDLS 92  Clostridium phyt...
CAJ68925      6 YKTSEFAELCGVKKHTLYHYDEIELLkPSITHE-NGYRYYTiDQFEKFNIISVLKkAGTPLEEIKQYLNdldtntflNVL 84  Clostridium diff...
CAJ67857      9 FTTGEFAKICGINKKTLFHYDDIGLFsPELKKE-NGYRYYSyHQLSIFGIISSLReVKMPLKEIKAYIDkrtpnlliELL 87  Clostridium diff...
NP_350033     7 LSTGELAKMLGVTKQTVIYYDKVGLIsPAKRGE-KHYRYYTlEQADELDSILTFRnLGVPIDTLKEYLSvrnaegciEML 85  Clostridium acet...
ZP_00800444   9 FTTGEFANLVGVSKDTLFHYDKIGVFsPEIKGN-NHYRYYSvYQAEVFNVIATLKeVNMPLKEIKAYLNkrtpdeyiLLL 87  Alkaliphilus met...
NP_782424     6 YKINEVAKMHNISKKTLIYYDKIGLFkPQYVDEeNNYRYYEmKELPILKQIVYLKkIGFSLKEIKNLLDnrehdlviEAL 85  Clostridium teta...
YP_619022     6 IKTGDFAKMCAVTKKALYVYEAKGLLkPAVVKD-NGYRYYRlEQVDQVATIRLLEkLGSSLQEVGDFFAlkdlnerqKYL 84  Lactobacillus de...
NP_561681     3 LSIGEVARLFNISKDTLRYYDKIGILkPEINKE-NGYRFYDiRHLEQLGLILGIKyLGISLSEIKEIIEngdiedyyNLM 81  Clostridium perf...
Feature 1                         
BAA12356     88 KEKSIEIDKKINELKQLQ 105 Bacillus subtilis
ZP_01361267  88 EQKSEEVTKELLRLQRVK 105 Clostridium sp. OhILAs
ZP_01354636  93 KEQLTQVKEEIKKLEQIQ 110 Clostridium phytofermentans ISDg
CAJ68925     85 HRKLMDLQEEVKKIEKMC 102 Clostridium difficile 630
CAJ67857     88 EKKTIDIKNEIEKLNNIQ 105 Clostridium difficile 630
NP_350033    86 GKQQERVILEIQKLDRIR 103 Clostridium acetobutylicum ATCC 824
ZP_00800444  88 EKEEASLDTKIRELQKMK 105 Alkaliphilus metalliredigenes QYMF
NP_782424    86 ISRDKEIMNAMEELQEMH 103 Clostridium tetani E88
YP_619022    85 GKQQEAVEREMAELGKIK 102 Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
NP_561681    82 QKQKDIIKERILELKKLE 99  Clostridium perfringens str. 13

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