Conserved Protein Domain Family
HTH_MerR-like_sg5

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cd04780: HTH_MerR-like_sg5 
Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily
Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 5), N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133407
View PSSM: cd04780
Aligned: 12 rows
Threshold Bit Score: 101.25
Threshold Setting Gi: 29833868
Created: 4-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
NP_828502    13 MRMSELSRRSGVSVTTIKYYLREGLLPAGRRLSaTQAGYDeDHLRRLRLIRALTgvRGLPVSAARDVLGala-------- 84  Streptomyces ave...
ZP_00995968   1 MRLAELSDTTGVAVATLKYYLREGLLHPGRAVSrTQSDYDeTHVERVRLVRALSevGGLSLATIGRVLDvitspgqdwit 80  Janibacter sp. H...
YP_288163     1 MRIGELSRRSGVSVPTIKYYLREKMLPEGERIAaNQVRYSeEHLRRLRLIRSLIdvGGLPVPTVREVLAe---------- 70  Thermobifida fus...
ZP_01430007   1 MRISELSKQSGLSVPTIKFYLREGLLQPGVRTGrNQAEYAeEHLARLWFVKVLTgpGRLGISDVREVLTa---------- 70  Salinispora trop...
ZP_01130211   1 MKISELSLETGASLATIKYYLREGLLPAGERSApNQATYSkAHVRRIHMIRALTdvGGLAVSDAKRVIDa---------- 70  marine actinobac...
YP_832383     1 MQLKELSERSGVSAASIKYYLREGLLPAGAAVHpTRAQYSaRHVERLELIQALRriVGLTIEQIRGLLRm---------- 70  Arthrobacter sp....
YP_182263     1 MRISEVAKAAGVSLPTIHYYTREGLLSPLLKTApNMAYYSpDCVEDIRLIKELQseKFLPLSVIKLVLQarrd------- 73  Dehalococcoides ...
YP_496756     1 MRMRELEEKTGVNREVIRILLRKGLLPEPLRLArNQAEYDeTHVRAVAVVRELQkgSRLTLDQIKELLDgngl------- 73  Novosphingobium ...
ZP_01304514   1 MKMRELEERTGVDREVIRIMIREGLLPEPQRPArNAAEYDeGHVSGIATIRHLQqtSRMTLKEIRSALSgeal------- 73  Sphingomonas sp....
ZP_00380938   1 MKLSALAAESGVSTASIKYYIHVGILPPGRKRNaTTAVYSqAHLDRLALITWLRreLGSPIESIAALTRs---------- 70  Brevibacterium l...
YP_394367     3 YKVSQIVKLTQTPKSTILYYIREGLLPEAKKLKsNVHRYSdIHVEILEYIRYMKqeMGSSNEELKTMLKn---------- 72  Thiomicrospira d...
ZP_01376995   2 LKMNELIQKSDTPKSTILYYVKEGLLPEPDKPKpNLYLYEeKCVQIIEFIKYLQinFNSSIAQIKALFShpsf------- 74  Campylobacter cu...
Feature 1                                   
NP_828502    85 --ehAGDTHSLLGLTLGSIRLAEESADD 110 Streptomyces avermitilis MA-4680
ZP_00995968  81 vlstAQRSLVGGREARVVDNLGRASAWV 108 Janibacter sp. HTCC2649
YP_288163    71 ----IDASQPSVHHAVALAHRGLPVLTG 94  Thermobifida fusca YX
ZP_01430007  71 ---iDSRGRPLRGLCSVISPTVAAMPMV 95  Salinispora tropica CNB-440
ZP_01130211  71 ----IESDLPLTRAFEIAQRTVSEQVDP 94  marine actinobacterium PHSC20C1
YP_832383    71 ----ADDGAPRLDLLAAVQRVVLELDSY 94  Arthrobacter sp. FB24
YP_182263    74 gqdiEHLGEMRTLLDDVFQPVVTGEPNP 101 Dehalococcoides ethenogenes 195
YP_496756    74 -dsgAGAQTYQHLEELLAIRFGLAETRL 100 Novosphingobium aromaticivorans DSM 12444
ZP_01304514  74 -erpGPASAYSHLEALLSRSFGLEQPTS 100 Sphingomonas sp. SKA58
ZP_00380938  71 ---iDDESLENIELMGICQRLALEASNV 95  Brevibacterium linens BL2
YP_394367    73 ----KNSSLSSSFSMIAPMMQTLENIPK 96  Thiomicrospira denitrificans ATCC 33889
ZP_01376995  75 dinnPYETLFKTLELIMGANFTRIYSID 102 Campylobacter curvus 525.92

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