Conserved Protein Domain Family
HTH_MerR-like_sg4

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cd04779: HTH_MerR-like_sg4 
Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily
Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 4). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133406
View PSSM: cd04779
Aligned: 5 rows
Threshold Bit Score: 138.793
Threshold Setting Gi: 68054875
Created: 25-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                 ###                                          
NP_979693     2 YRIGQLALMAHVSKRTIDYYTNLGILk-AERSQS-NYRYYDeTAVETLQFIEKCKeMHMPLCEIKEKIEekkkl----lg 75  Bacillus cereus ...
NP_388837    12 YRISELAALAGVTKRTVDYYTNLGLLt-PARSCS-NYRYYDeNALKRLIFIVDCKkQRLALSDIKDRLEnqfpssakldd 89  Bacillus subtili...
NP_924456    89 YRIGELAHLAKVNPRTIDFYTREGLLepLDRADAhQHRYYPaTSLDRLDLIKHLRgRHMSLAEIRDQLKcvqr------p 162 Gloeobacter viol...
ZP_01150238   2 YRIGQFAKLAGVSRRTVDYYTKLGLLe-PVRSES-NYRYYNqDALIRLKLIEMLKsQRLTLEEIKGQIEyisnvmnsdkk 79  Desulfotomaculum...
ZP_00539024   2 LKIGQVAEATGLSKRTIDYYTSLGLLt-TERTPA-GYRLYTeDVVQHIQKIEYLKtQRLSLQEILAFFTerev------k 73  Exiguobacterium ...
Feature 1                                                                   
NP_979693    76 inEHVSKQVNEVTDHIHRLEAELTELKplldgltdsqreKISKSLSgQTTALIQTLALLL 135 Bacillus cereus ATCC 10987
NP_388837    90 eiGNLALEIDHMNQNISGILHRFERLKped-------rdKLKSKLPpEKLAVFQSFMLLL 142 Bacillus subtilis subsp. subtilis st...
NP_924456   163 eqREVIQTLQLVCRQIDDLQHQLKDLSpiasqtdralvmVMTVEAMqKVATLTAALTTLL 222 Gloeobacter violaceus PCC 7421
ZP_01150238  80 kySQRAIDIQYLKDQFKVLETQLGQLQpmvtnmeagqaaAMTKQVLiQSMTIIQSLLLYI 139 Desulfotomaculum reducens MI-1
ZP_00539024  74 tgDAIYQEVQQLQESVNGLEQRLLQSTdye-------kqEIRLELS-QRLTLIASLIAQL 125 Exiguobacterium sibiricum 255-15

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