Conserved Protein Domain Family
HTH_MerR-like_sg1

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cd04777: HTH_MerR-like_sg1 
Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily
Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 1), N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133404
View PSSM: cd04777
Aligned: 6 rows
Threshold Bit Score: 148.714
Threshold Setting Gi: 106894910
Created: 4-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #              ###                                             
ZP_00909652   1 MKIGKFVKANNLTIDTVRHYINMTLIIPEKHGGQYNFDdRCQSDLEDILLLKGMGFSLSEIKSIFMFKRLAKLTKYEENE 80  Clostridium beij...
NP_979003    28 MKIGKFGEVNNISIDTIRHYMDLSLIIPEKKGGHYFFDeYCQTDLELILYYKDLGFSLNEIKELFFYKNLAKSMNHEKDT 107 Bacillus cereus ...
ZP_00801069   1 MKIGAFSAKHNITIDTVRHYIDLGLLLPHKKGGQYEFTsKDSNDLQGVLELKGLKFTLGEIQKVFSYKRITGMRTIQDQL 80  Alkaliphilus met...
ZP_01360777   1 MRIGEFAKKYDLTIDTIRHYMDIELLLPEKKGGHYFFGeKEEMNLKEILDLKALKFTLSEIQKIIGYSRLSQLRTKEDQK 80  Clostridium sp. ...
ZP_01362022   1 MRIGEFAKKHRITQDTIRYYLDMGLLVSEKKGGQYKFTkADSEDMERIIELKSLDFSLIEIQKILTFQRLSGSNTDVFRN 80  Clostridium sp. ...
ZP_01186966   1 MKIGTFAKLFHVTTDTVRYYIELGLLIPDKKNTQYQMNqLCFDDMTFITELKKFHFSLIEIQRILSYRRVTNFSDHEDID 80  Bacillus weihens...
Feature 1                                  
ZP_00909652  81 CFKSFFVNKDKEIENKIRELKLMKQKL 107 Clostridium beijerincki NCIMB 8052
NP_979003   108 FYQSLFKLKYDKMEQEIELLEEKRDKL 134 Bacillus cereus ATCC 10987
ZP_00801069  81 RYKKILEEKTEELVAEQKHLAKTVMYL 107 Alkaliphilus metalliredigenes QYMF
ZP_01360777  81 YIRAILWHKKNTLAEEERSIKNALEIL 107 Clostridium sp. OhILAs
ZP_01362022  81 LYLPFLKNKKEEVEKELIKYNRMNEFL 107 Clostridium sp. OhILAs
ZP_01186966  81 YYNNSLIDKKDELTKKKEDISKAIQLI 107 Bacillus weihenstephanensis KBAB4

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