Conserved Protein Domain Family
HTH_Cfa-like

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cd04775: HTH_Cfa-like 
Helix-Turn-Helix DNA binding domain of Cfa-like transcription regulators
Putative helix-turn-helix (HTH) MerR-like transcription regulators; the HTH domain of Cfa, a cyclopropane fatty acid synthase, and other related methyltransferases, as well as, the N-terminal domain of a conserved, uncharacterized ~172 a.a. protein. Based on sequence similarity of the N-terminal domain, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133402
View PSSM: cd04775
Aligned: 3 rows
Threshold Bit Score: 141.907
Threshold Setting Gi: 78060378
Created: 13-Nov-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###             #                 ###                                         
ZP_01166093   1 MFTVFQVCETLDISRSTLLYYERRGLI-TAVRNPanNYRLFPqSEIDKLRAIKLLQAGGLSLSESLSCLQgkl--tpGQM 77  Oceanospirillum ...
YP_366953     1 MYRISELATKAGLSRSTLLYYEKMGLI-SSTRQAn-GYRTYTdQDLQQLKLLQQLQAGGLTLKECQACLEtri--drSLL 76  Burkholderia sp....
YP_437552     1 MYTIGQMSRKFGVSRSTLLYYDSIGLLsPSARSEa-NYRLYSeADLSRMEKIVFYREAGLPLENIAGVLAqphdgvqAIL 79  Hahella chejuens...
Feature 1                                 
ZP_01166093  78 HERLSSLAEQINRLEQAYSILQALSG 103 Oceanospirillum sp. MED92
YP_366953    77 LERLQSLEQEIAEKQQSRDLLAAMLG 102 Burkholderia sp. 383
YP_437552    80 EQRLQSINREIQRLRAQQQVIATILK 105 Hahella chejuensis KCTC 2396

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