Conserved Protein Domain Family
HTH_YfmP

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cd04774: HTH_YfmP 
Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator
Helix-turn-helix (HTH) transcription regulator, YfmP, and related proteins; N-terminal domain. YfmP regulates the multidrug efflux protein, YfmO, and indirectly regulates the expression of the Bacillus subtilis copZA operon encoding a metallochaperone, CopZ, and a CPx-type ATPase efflux protein, CopA. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133401
View PSSM: cd04774
Aligned: 4 rows
Threshold Bit Score: 123.391
Threshold Setting Gi: 15807297
Created: 8-Dec-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ###             #                ###                                           
BAA20105    4 MKIDQVAKRSGLTKRTIRFYEEIGLIpaPKRTDgGVRLYSeDDMEELEKVISTKe---vLGFSLQELQHFMEtsrqleln 80  Bacillus subtilis
NP_835034   2 YKIDEVTKQVGLTKRTLRYYEEIGLIhpPERSEgNIRLYTdEDIARIKRIVEAKe---vLGITLQEMQHFLSlkerme-- 76  Bacillus cereus AT...
YP_558658  20 LTVRDAAERLGVTPRTLKYYEERGLVs-PTRSEgRYRLYDeEDLKRFGRILRLRs----LGFSLHSVTEMLKrplep--- 91  Burkholderia xenov...
NP_296027  10 YKVGEVAARLGLTLRTLKYYEELGLVt-PERTDsRYRMYSeADVQRLERIRRMRalglsLGTIQAISTHPQEsdp----- 83  Deinococcus radiod...
Feature 1                                 
BAA20105   81 kegyllsldPKERKEKLEEIQETLNHQL 108 Bacillus subtilis
NP_835034  77 ---qrrnseNPRDREVIQEIKDMLEKQV 101 Bacillus cereus ATCC 14579
YP_558658  92 -----vdggHRYSAESLRQIHDAIAQQV 114 Burkholderia xenovorans LB400
NP_296027  84 ------dgrQVLTQEALHTLESDLSSQL 105 Deinococcus radiodurans R1

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