Conserved Protein Domain Family
HTH_TioE_rpt1

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cd04772: HTH_TioE_rpt1 
First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE
Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.
Statistics
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PSSM-Id: 133399
View PSSM: cd04772
Aligned: 9 rows
Threshold Bit Score: 122.886
Threshold Setting Gi: 81681114
Created: 13-Nov-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                ###                                           
CAJ34361      3 FRPADLAHEHGLSPQSVRNYERDGLIPPARRTEsGYRRYTeKHAAALRAYRALIpahGYAESGAIMRDITAgrln-ealT 81  Micromonospora s...
ZP_01427849   7 FRTVDLAKAINVSVQQVRNYQAEGFLPNVERGSnGYRQYTqQHIDAIKTAHQLIkgyGWRNAQQIMAALHQanhq-tafN 85  Herpetosiphon au...
NP_628643     8 LRTVDLARAVGLSTQQVRNYEDAGVLPPAGRTDaGYRVFGeRHRDALLTYRALQpgyGAVTATRVMRAVHAgdva-galA 86  Streptomyces coe...
YP_700217     9 LRTVDVARRAGCSVQHVRNLERDGVLPPATRTAtGYRIYTdVHVQSALAYRELAigvGPVEATRIVRSVHTcpaa-ttvA 87  Rhodococcus sp. ...
ZP_01431216   9 YRPVDLARAHGLSAQAVRNYEAAGVIPPARRTAsGYRIYTdDQAAALTAYVALVrgyGFQPAGKIMRLVLRddlp-salA 87  Salinispora trop...
YP_177270     4 YRPIDIARELNISTSALRHYESWGIIPPPERAAnQYRLYTnEHLAYFRCLRAMIpgfGFPLTAKVLRAVQNgdvd-kafW 82  Bacillus clausii...
NP_350095     4 YRPIELAKMFNLHSNTIRFYESIGYISKASRKPnGYREFTdKHILQLTICRHIL---GYRYTNRHIRDTGKliiicsaeS 80  Clostridium acet...
ZP_01369029   4 YKTSEIAHSIGIHPNTVRLYEELELIPKPLRKAnGYRVFTdFHMEQIKLARIAL---KVEVLQNGLRKQAIaiiktsalG 80  Desulfitobacteri...
ZP_01229481   4 YTTSEVADLIGVHPNTVRLYEELNLIPKPKRNTnGYRIFNdFHIEQFRFARTAL---KIEVVQRGLRKDALeivrtsanR 80  Clostridium diff...
Feature 1                           
CAJ34361     82 TIDRSHAELLRDRGTLDAVA 101 Micromonospora sp. ML1
ZP_01427849  86 LINQHHAKLDSIRQQLDQTL 105 Herpetosiphon aurantiacus ATCC 23779
NP_628643    87 LVDAAHAALHEERVALRAAG 106 Streptomyces coelicolor A3(2)
YP_700217    88 LLDAAHARLHTERTELALAK 107 Rhodococcus sp. RHA1
ZP_01431216  88 IVDAAHVLLQRDRETLDQVT 107 Salinispora tropica CNB-440
YP_177270    83 LVSGEQAQLYNEKTVAEQTL 102 Bacillus clausii KSM-K16
NP_350095    81 KLIEGKQYAQDYIKIIQNEI 100 Clostridium acetobutylicum ATCC 824
ZP_01369029  81 KFSKAICLTEYYRQQIRNEQ 100 Desulfitobacterium hafniense DCB-2
ZP_01229481  81 DFDKAISLVNQYLQQLEIEK 100 Clostridium difficile QCD-32g58

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