1EXI,1JBG


Conserved Protein Domain Family
HTH_BmrR-like

?
cd04768: HTH_BmrR-like 
Click on image for an interactive view with Cn3D
Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators
Helix-turn-helix (HTH) BmrR-like transcription regulators (TipAL, Mta, SkgA, BmrR, and BltR), N-terminal domain. These proteins have been shown to regulate expression of specific regulons in response to various toxic substances, antibiotics, or oxygen radicals in Bacillus subtilis, Streptomyces, and Caulobacter crescentus. They are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
?
PSSM-Id: 133396
View PSSM: cd04768
Aligned: 8 rows
Threshold Bit Score: 120.92
Threshold Setting Gi: 16800165
Created: 25-Jan-2007
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Structure:1EXI; Bacillus subtilis BmrR bound to DNA; defined at 3.5A contacts.
    View structure with Cn3D
  • Comment:these residues contact two consecutive major grooves

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1      ###             #                 ###                                          
1EXI_A      6 YSIGEVSKLANVSIKALRYYDKIDLFkPAYVDPdtSYRYYTdSQLIHLDLIKSLKyIGTPLEEMKKAQDleme-elfAFY 84  Bacillus subtilis
1JBG_A      3 YQVKQVAEISGVSIRTLHHYDNIELLnPSALTDa-GYRLYSdADLERLQQILFFKeIGFRLDEIKEMLDhpnf-drkAAL 80  Bacillus subtilis
BAA12356    9 FTTGEFSKLCRVKKQTLFHYDEIGLFsPEIKKEn-GYRYYSyHQFETFQVISLFKeLGVPLKEIKCLIKgktpdkilHVL 87  Bacillus subtilis
NP_470433   4 LSTGEIAQLFQISKYKIRHYIDEGILvPKRNPEn-GYYYFEeADIYRLYQIILFRkIGFSIQEIKESLLsek---vtPML 79  Listeria innocua C...
YP_794991   2 LTIRKFAELAGTTRRTLLFYDQEDVFkPAHIADn-GYRYYSyDQLYQLKFILQLRhLDLPLATIKELLAtndatqlnEQL 80  Lactobacillus brev...
CAE46893    7 LSISEFAKIAQTTRRTLIFYDQKDIFkPAKIAEn-GYRYYSyGQLYQIGFILGLRdLGLSVEEIKDYLSddssdalnKKL 85  Lactobacillus helv...
YP_803932   6 VTISTLARLLKTTNHTIRYYEDEGLFkPAEIAPn-GYRKYGmSQAYQLSFILFLRqLDFSVASIKQILQtnp--svtDLL 82  Pediococcus pentos...
YP_395423   6 LTISAFAKLFKTTQYTIRYYEDKGLLlPAKIAEn-GYRQYGmAEAYQLSFILFLRaLDLSVAEIKLILTtdy--peqTML 82  Lactobacillus sake...
Feature 1                       
1EXI_A     85 TEQERQIREKLDFLSALE 102 Bacillus subtilis
1JBG_A     81 QSQKEILMKKKQRMDEMI 98  Bacillus subtilis
BAA12356   88 KEKSIEIDKKINELKQLQ 105 Bacillus subtilis
NP_470433  80 EQAEQDLQQKIEELVEIQ 97  Listeria innocua Clip11262
YP_794991  81 RTVLSHIQTEIDNLTLLK 98  Lactobacillus brevis ATCC 367
CAE46893   86 IPLRQKIEQRIQNLQQIL 103 Lactobacillus helveticus
YP_803932  83 LAKKIAIQTERHRLEQLE 100 Pediococcus pentosaceus ATCC 25745
YP_395423  83 LNKKQALQQEIARLQALE 100 Lactobacillus sakei subsp. sakei 23K

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap