Conserved Protein Domain Family
HTH_HspR-like_MBC

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cd04767: HTH_HspR-like_MBC 
Helix-Turn-Helix DNA binding domain of putative HspR-like transcription regulators
Putative helix-turn-helix (HTH) transcription regulator HspR-like proteins. Unlike the characterized HspR, these proteins have a C-terminal domain with putative metal binding cysteines (MBC). Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133395
View PSSM: cd04767
Aligned: 4 rows
Threshold Bit Score: 187.703
Threshold Setting Gi: 116747808
Created: 26-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###             #              ###                                            
YP_430303     6 LYPISVVAELLGIQPGTLRVWERHKLIQPARKNGRRLYSNNDLKRLRFIKRLID-KGFNLNSLKHYLAFYPCWLL--EDC 82  Moorella thermoa...
YP_519297    18 LYSIGTVAELIEEHPETLRVWERNGLIHPNRDKYQRKYSNNDLLRLKFIKYLMNeKGLNIAGVKQITSMYSCWYNrnCKG 97  Desulfitobacteri...
YP_844495     9 LYPIGIVAELLNIHPRTLRIYEQEGLIKPARRGGKRFYSNIDLQWLRCLRKLLTdEGLNIAGIKKLLTIAPCWSIrdCDE 88  Syntrophobacter ...
ZP_01147991   9 MFNIGVIAELLKVHPETLRIWEKHGLVEPSRRNKQRLYSNNDVKRLQFIHFLINeKGLNIAGVLQIISMYPCWSTk-HCA 87  Desulfotomaculum...
Feature 1                                               
YP_430303    83 PSCSHKTERIGCAKPCWKEegTYCLIsfEDPSLCSKCPYK 122 Moorella thermoacetica ATCC 39073
YP_519297    98 GGMRSSTIPINESKPCWKIegTYCFIasDKSELCSTCEML 137 Desulfitobacterium hafniense Y51
YP_844495    89 ETRKQCPAILNFPVPCWELk-PRCCK--DSDLACSDCEVY 125 Syntrophobacter fumaroxidans MPOB
ZP_01147991  88 GGNQSKDEKVNINKPCWKEqgTYCYVieDKADQCSACPHY 127 Desulfotomaculum reducens MI-1

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