Conserved Protein Domain Family
HTH_MlrA-like_sg2

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cd04765: HTH_MlrA-like_sg2 
Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators
Putative helix-turn-helix (HTH) MlrA-like transcription regulators (subgroup 2), N-terminal domain. The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133393
View PSSM: cd04765
Aligned: 30 rows
Threshold Bit Score: 99.2485
Threshold Setting Gi: 91222808
Created: 11-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###                     #                 ###                                  
YP_356841    11 FKIGEVAQLTGV--------KPHVLRYWESEFRQi-rPVKSQgKQRLYRrDDIEFVLNLKDILYgqGYTIAGAKKILAkq 81  Pelobacter carbi...
YP_616463    18 LAIGELAERIGV--------PTHVLRYWETRFPQl-rPLQRSgRRRYYRaEDVALAERIHHLLHvqGFTVEGARKALAkd 88  Sphingopyxis ala...
ZP_01449195  10 RTITEVSEWLKT--------PSHVLRFWESKFTQi-kPVKRAgGRRYYRpEDLKVIGGIKYLLHdkGTTIAAVKELFKsk 80  alpha proteobact...
YP_759883    16 RSIGEAAAELGL--------ETHVLRYWETRFPRqvhPVKRPdGRRLFRpQDIDALRAIRILVHerGMTLKGAKAVLSqq 87  Hyphomonas neptu...
ZP_00629603   9 RSIGEVSRLVGV--------APHVLRYWESQFTQl-aPVKRAdGRRYYRpDDVRLAAGLCQVLReeGLSIRGAKRLIGad 79  Paracoccus denit...
ZP_01016133   9 RTISEASEELGL--------AQHVLRHWEDMFGAi-rPMRRAgGRRFYRpQDLHLIYGVKILIHekGFTTKGVQRIFAek 79  Parvularcula ber...
ZP_01258127   9 KTIGEVAKILNLksnnkgalPTHVIRFWETQFKQi-kPKILNsNRRYYDeKTINLLKKVKFLLKdqGMTINGVKKILNne 87  Psychroflexus to...
NP_965887     8 YTIGEVAEELHL--------EQHVLRFWEGQFHQi-kPTKRK-GRRLYDrKCIEAIKKVKYMLYdkGYTIKGVQKEFGn- 76  Wolbachia endosy...
YP_266444    10 KSIGEVAKILGLvnkkkgtlNTHTIRFWEKEFKQi-kPKILNgNRRYYNnDTIEVLKKVKYLLKdqGMTIIGVKKVFNsd 88  Candidatus Pelag...
YP_302757    14 QTIGEVAKCLNV--------EQYVLRFWEEKFPQi-nPIKRR-GRRLYTqVDVDILKYIKHLLYdkGYKIKGVQQELSkk 83  Ehrlichia canis ...
Feature 1                                                
YP_356841    82 agseka--------assvnpeeAVELLRDIRRDLLQLRASL 114 Pelobacter carbinolicus DSM 2380
YP_616463    89 gaaptsva----iatptigndpARKGAGVPVEALVALRERL 125 Sphingopyxis alaskensis RB2256
ZP_01449195  81 gekh-------------ikeysIEPIFPDKTSRKSKTVNEK 108 alpha proteobacterium HTCC2255
YP_759883    88 gvaav----------ldgtatiTPDSAPSPARALQQTLARA 118 Hyphomonas neptunium ATCC 15444
ZP_00629603  80 rgsalreigaarlgeaqgdagpAERPAPSPAVRLALPGSAE 120 Paracoccus denitrificans PD1222
ZP_01016133  80 gas---------------hitdIGKRALEGAPESAATTPET 105 Parvularcula bermudensis HTCC2503
ZP_01258127  88 vslkldei-----adksirtenLRNKLLRISNKLKELKYGK 123 Psychroflexus torquis ATCC 700755
NP_965887    77 ----------------------DIKVTKNLLQELTDLRDYL 95  Wolbachia endosymbiont of Drosophila melanogaster
YP_266444    89 kslkldel----pnnsinadynLKNKLKKISDLIKKIKSLK 125 Candidatus Pelagibacter ubique HTCC1062
YP_302757    84 pvnidks-------nasvkqnvYREGLISLLDDMLNLRNDL 117 Ehrlichia canis str. Jake

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