Conserved Protein Domain Family
HTH_MlrA-like_sg1

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cd04764: HTH_MlrA-like_sg1 
Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators
Putative helix-turn-helix (HTH) MlrA-like transcription regulators (subgroup 1). The MlrA protein, also known as YehV, has been shown to control cell-cell aggregation by co-regulating the expression of curli and extracellular matrix production in Escherichia coli and Salmonella typhimurium. These proteins belong to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by reconfiguring the spacer between the -35 and -10 promoter elements. Their conserved N-terminal domains contain predicted HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules. Many MlrA-like proteins in this group appear to lack the long dimerization helix seen in the N-terminal domains of typical MerR-like proteins.
Statistics
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PSSM-Id: 133392
View PSSM: cd04764
Aligned: 9 rows
Threshold Bit Score: 76.9853
Threshold Setting Gi: 114565940
Created: 11-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #                 ###                                
ZP_01361430   8 YSISQVAEYTGFKPHVIRFYEKEFNLn--IPRSEnARRYFTKKEINLFLYIKSLQe-kGSSNKEIKKLLK 74  Clostridium sp. OhILAs
ZP_00801427   9 YSMKDVSQITKFKPHVIRFYEKEFELn--IPRASnNRRYFTDTELSQLLTIQSLQe-qGLSNKKIKEVLL 75  Alkaliphilus metalliredige...
ZP_00505037   8 YSITELSGYLNVTDHTLRYYEREFNLy--VPKDKrGRRYYTPELANIMYKIKTMRd-eGLEIKAIKKILQ 74  Clostridium thermocellum A...
CAD30188     13 YKMKEVSELTGLSNDLLRVYEEEFNLq--INRTNgGHRRYTEDDINKFISIKKKIqeqNWSYKKVRSWLN 80  Bacillus thuringiensis ser...
YP_753094     6 YKISEISEILGVEQYTLRYLENSLGLk--IKRNErGDRLYSESDLETLKLVLQLKn-kGLNTTAIKMALE 72  Syntrophomonas wolfei subs...
ZP_01355167   6 YMITEASKMIEVKPNELRYMEDQLELd--IPRNElGYRYYKLQDIELLKTVNILKn-eGFSFKVIQMILP 72  Clostridium phytofermentan...
ZP_01169344  12 YTIKEVSKKIGVPSGTLRQWEKDLNGllvIPRSKqGVRFFTDTEIELLGKIKEMRe-kNLSKEMIRHLMQ 80  Bacillus sp. NRRL B-14911
YP_147601     4 YTLREAAKKIGVTARDLKQWEKQFAGsiaVPRTTeGARMYTDELIDRFRHIRTWLe-dGRHPREVAEMIR 72  Geobacillus kaustophilus H...
ZP_01188439   6 YTTSEAAEILNVAPSTLRYWESELGNylkIPRDKnGYRKFTPDNIETLKKIKEYLyerKFSIKQVREILN 75  Halothermothrix orenii H 168

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