Conserved Protein Domain Family
HTH_MerR-trunc

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cd04762: HTH_MerR-trunc 
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins
Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.
Statistics
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PSSM-Id: 133390
View PSSM: cd04762
Aligned: 37 rows
Threshold Bit Score: 54.5126
Threshold Setting Gi: 57641776
Created: 8-Nov-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###             #               ###             
ZP_01427479  13 LSLSEASDLLGAAPSTVRRWGDAGLVpTKRTLgGHRRFQrAAVERMVNQ 61  Herpetosiphon aurantiacus ATCC 23779
YP_629353    14 YTTHDISRLLQVDPSTVSKWIDRGILmAFRTPgGHRRVRsADLRTFLIT 62  Myxococcus xanthus DK 1622
YP_466777     5 YTTFEAARLLGVSLPTVVNWIEARRLkAHRTPgGHRRIArEELAAFMLR 53  Anaeromyxobacter dehalogenans 2CP-C
NP_627895     4 YTIGQAARLLGVSPDTARRWADAGRVaTHRDEaGKRLIDgKDLAAFSVE 52  Streptomyces coelicolor A3(2)
YP_120540     4 LRVSEAAALLGVSDDTVRRWMDQGKLpAIQLDnGRKGVAgKDLAEFLRS 52  Nocardia farcinica IFM 10152
ZP_00657802   3 YRIAEAAELLGVSDDTVRRWVEAGRL-ATRQQdGRSVVPgADLAALAES 50  Nocardioides sp. JS614
Q5WGB8        1 MKTKEMSEAIGVNPTTIQRWTKYFKIdCDVTEqGHFLYTeKHLQLFKKI 49  Bacillus clausii KSM-K16
ZP_01171972   3 MNTNKAASSLGVSPSTIQRWVKQFGLeVGRNElGHYHFEeDQLEILKDI 51  Bacillus sp. NRRL B-14911
NP_391584     1 MNTNMVASELGVSAKTVQRWVKQLNLpAERNElGHYSFTaEDVKVLKSV 49  Bacillus subtilis subsp. subtilis str. 168
YP_081028     1 MNTADAANELGVSTKTVQRWVKQLQLpASRNElGHYFFTeDDIAILKEV 49  Bacillus licheniformis ATCC 14580

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