Conserved Protein Domain Family
OYE_like_3_FMN

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cd04734: OYE_like_3_FMN 
Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase. One member of this subgroup, the Sinorhizobium meliloti stachydrine utilization protein stcD, has been idenified as a putative N-methylproline demethylase.
Statistics
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PSSM-Id: 240085
Aligned: 28 rows
Threshold Bit Score: 435.889
Created: 17-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Citation:PMID 7881908
  • Comment:Based on similarity to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # #                               #                          
ZP_01140041   6 LFSPLKLGtTEVKNRISFQPHLTNLaiGNLPSERQMYYWGERAKGGaGLIITEELTVHPTdmayekliDVYHAEVIPGFK 85  Geobacter uraniu...
NP_882944     7 IFSPLRIGgVEIPNRIVRTAHATRLa-QGYVNDDLIAYHLERAKGGaGLSILESTSVHPSstf---slSAADDGAIAPMR 82  Bordetella parap...
ZP_01609655   6 ILSPILINgLEIRNRVARAAHGTSYg-RGAISDDLIAYHEARAKGGvGLNILEATVVHPStsn--htvNALDDSIIPGFA 82  Sphingomonas wit...
YP_705647     9 LFSPLRIGnVTLANRIVSSGHDTVLvqQGKVTAELVAYHEARAAGGaGMIVVQVAGVHETarytshvlMATDDDCIPGYR 88  Rhodococcus sp. ...
ZP_00380094   8 LFEPITLGaRTIRNRIVSSGHDTVLddHGQIGEDLIAYHEARAEGGvGLIVLQVSGVHETarytnhvlMATDDSAVPGYR 87  Brevibacterium l...
ZP_01606638   5 ILDPITINkLDVKNRVVITPHGTFLs-VDSFSEAAIAYQTARARGGcGLSIVECTSTHPSsvn---tlNNFDDRVIPGFK 80  Sphingomonas wit...
ZP_00960149   9 LFAPITLGkLTLRNRIVSTGHETHLnqEGQIGEKLIAYHEARARGGaGLIVTEVALVHPSavfvadpiRVDSDACIPGYR 88  Roseovarius nubi...
ZP_01609632   5 ALSPIRIGgLEIRNRIARTAHATMMarDGKITDELIAYHLARAQGGvGLTILEAAGVHPSavl---slANLDDTIIDGYR 81  Sphingomonas wit...
ZP_01036525  10 LFAPLTLGdFEIRNRIASTGHQTFLaeNNLPGDALVAYHEARARGGaGLIITEAARFHESafaaprelHLVEDSAIPAYA 89  Roseovarius sp. 217
ZP_00959726   6 LSSPYQLRhKTVRNRITFGAHTANMaqDGLPGPQFGAYLLERALGGaGMIVCEPVPVHRTgvltrgnfRHEDDSVIPAFR 85  Roseovarius nubi...
Feature 1                      #                                                                
ZP_01140041  86 KITDYVHQyDAKIFAQLNHNGQqgd--gsiSRLP-VWAPSPIPDVLFREt-PKAmepEDIEEVARYFAKSAIHVREGGFD 161 Geobacter uraniu...
NP_882944    83 RLADAIAPtGMKLFTQLWHGGYtdp---aaDGGL-PWAVGPLPGRYSVAp-PIPmttGQIGELVEAYGKAAARMQAAGLH 157 Bordetella parap...
ZP_01609655  83 KLGEACSRhGMRTFVQLWHGGHrwa---paNGQA-PLSASDVPCPLGVTntPQPmtlDQIEEITEAFADAAERVRKGGLD 158 Sphingomonas wit...
YP_705647    89 RIADVCHRhECVVVGQIFHPGReilesqdgSTPV-ALAPSAVPSERFHVm-PRAmtaGEIDAVVQGYGDAARRLQRAGLD 166 Rhodococcus sp. ...
ZP_00380094  88 GVAEAVHRhGATIFAQLFHPGRevmd-gerGMAPrAVAPSDEPQERFSVv-PETlstDMVKDIIAGYASAAKRITAADID 165 Brevibacterium l...
ZP_01606638  81 KMMASIEPyGMRMFQQLYHGGHnan---qpGKRP-PLAPSAVHGTELKGv-PVPlleEQIEEIVASFGDAAARCQEGGLH 155 Sphingomonas wit...
ZP_00960149  89 RLADRIHAhGTGLIAQLFHPGRemia-sedGTAPvSYSASATPNERFHVm-PRPmppEMIAEVISAYGDAARRMEEAGLD 166 Roseovarius nubi...
ZP_01609632  82 RLATAIAPtGMRLFQQLWHGGHiym---qpDGSP-PLAPSTVPSPIAGVa-PRPftrWQIDELVAAYGAAARRVEKGGLD 156 Sphingomonas wit...
ZP_01036525  90 RLAKVVQGhGARIIGQLSHSGRvshrmregHRGV-AYAPSSVPDRRYQTv-PRQmstELIEELVSAIGAGARRYADAGYD 167 Roseovarius sp. 217
ZP_00959726  86 RIVEPVQDaGAVILQQLYHVGAhgd--sdlSFAP-HWSPSGQPSYHDSDg-SHAmteAEIEDIIAAFIAAARRCQQAGFD 161 Roseovarius nubi...
Feature 1                #                                               #                      
ZP_01140041 162 GIELQFgHSSLARQFLSPLTNFRNDEYGGSLENRMRAPLKFIAAVRKAVgNDFTLGIRMCADEMipggldlaQVQEICAR 241 Geobacter uraniu...
NP_882944   158 GVEVLAgAGYLFSQFFSPVLNQRDDAYGGSFDNRIRALLETLRAIRAATsPDFALGVRIGGSTDaril-stdDVNAIALR 236 Bordetella parap...
ZP_01609655 159 GIELHCgHGYLVHQFLCPLTNRREDDHGGSLENRMRFMHGILGAIRKRVgDDFPLGIRISDYNApggf-speEAGEVVAR 237 Sphingomonas wit...
YP_705647   167 GVEIVAsHGYLPAQFLNPRTNLRTDEYGGSAENRQRFLRAALAAVRAAVgRDFVVGMRISGDEMgsdglrpdESQAVCAS 246 Rhodococcus sp. ...
ZP_00380094 166 GVEIVAsHGYLPIQFFNPRINSRTDEYGGSPANRRRFLAEVVAGVRAAVgPDIVVGLRISGEEKtedglvagEILDLIAA 245 Brevibacterium l...
ZP_01606638 156 GVEIHGaHGYLVHQFLSPLVNRRDDKWGGSLENRMRFLQEVLRAVRRKVgRDYVVGVRLSASNAtggi-telEQRQVVDA 234 Sphingomonas wit...
ZP_00960149 167 GVEVVAsHGYLPAQFLNPEVNQRDDDYGGSLENRTRFLREIAADIRAKTgAGFVVGMRLSGDERshegleqsDTLDAWAH 246 Roseovarius nubi...
ZP_01609632 157 GVEIHAgHGYLLAQFLSPVLNRREDDYGGSFDNRMRLLRRVLAAVRDAVsPGFAVGVRLSDSADpril-amdDVGEVARR 235 Sphingomonas wit...
ZP_01036525 168 GVELMAsHGLLFAQFLNPAVNRRTDDYGGTLDNRMRFLCESLAEVRRKIrIGMVIGLRISAEDFevdgaepdEIESACSY 247 Roseovarius sp. 217
ZP_00959726 162 GVEIWAaYHSLLDQFWTPWSNRRDDQWGGSLENRTRLSMRILEGIRRACgEDFIVGLSVSQSHStevlnspeALCDIVAR 241 Roseovarius nubi...
Feature 1                                                                                       
ZP_01140041 242 FEAsg-----lIDFMDLSIATfynl---ylvEGSMHTPLGyt-ipLAAGIREri-kLPVFCTGRINDPVMAEKVLANGQA 311 Geobacter uraniu...
NP_882944   237 AQAeg-----lIDFVNITHGDyyfh---verYAGMDRPVGyq-lpASDHVSQgi-tVPRIIVGRYATLDDAEQALKEGHA 306 Bordetella parap...
ZP_01609655 238 VCAdg-----lVDYVSGSMGSpysi---asmLGCMDQPSGym-lpSAEPIVQra-tVPTMIAGRFGTLDEGEQVIRAGLA 307 Sphingomonas wit...
YP_705647   247 LDAdr-----lLDYVSVCAGSssslsgavhiAAPMTESAAyt-apLAAAVKSvv-rVPVIVAGRINQPHEGDAVIAQGQA 319 Rhodococcus sp. ...
ZP_00380094 246 LDQmecegvacLDYFSITAGDsstlqgavhiVPSMQVEPGya-asLSEQVKKit-dKPVMVAGRINQPHEAEAAIAEGRT 323 Brevibacterium l...
ZP_01606638 235 LIAed-----lIDYVSGSYGDyyem---rymVGTMAEPTGym-lpSASQILKdv-pLPRLTAGRFRTLDEAQQVLNDGIA 304 Sphingomonas wit...
ZP_00960149 247 IADha-----tLDYLSVVAGSsatlagsvhiAPPMYEEAGyt-apLGQAIKTrt-gLTTIVTGRINQPQEAERIIASGQA 319 Roseovarius nubi...
ZP_01609632 236 LRDeg-----lIDYVNMSYGDyyal---hrqVGGMDAPTGfqiphTAPPVADf--gLPRLLNGRFRTLEEVEQVLRAGEA 305 Sphingomonas wit...
ZP_01036525 248 LAKtg-----aINYLNVTAGSmaglggsihvVPPMEIASAyl-asHAGRLRTat-sLPVLVAGRINQPQEAEQVLAANHA 320 Roseovarius sp. 217
ZP_00959726 242 HDAtg-----hLDYVTCGAGGyldf---ehlMPTFVLGEKpt-vsTTALLKStlthAKVQAEAGIRTPENAESVLSAGEA 312 Roseovarius nubi...
Feature 1            ##                           
ZP_01140041 312 DMIGMCRGLICDPFLPKKAQEGRLEDIRYCIACN 345 Geobacter uraniumreducens Rf4
NP_882944   307 EMISIVRGMIADPMLVAKARDGRGTEVRPCISCN 340 Bordetella parapertussis 12822
ZP_01609655 308 DMVSYVRALIADADLVAKSAAGNAIGVRPCIGCN 341 Sphingomonas wittichii RW1
YP_705647   320 DACAMTRALICDPAMPAKAERSEVDSIRACIGCN 353 Rhodococcus sp. RHA1
ZP_00380094 324 DMAVMTRAMICDPAIAAKSQRDAVDEIRACIGCN 357 Brevibacterium linens BL2
ZP_01606638 305 DMVGMLRAHIADPNLISKTIAGKVEEVRPCIACN 338 Sphingomonas wittichii RW1
ZP_00960149 320 DMCGMTRAMICDPEIGNKAGEGRLDDIRACIGCN 353 Roseovarius nubinhibens ISM
ZP_01609632 306 DLISMVRAHIADPDIVAKSAAGHPDRVRPCIACN 339 Sphingomonas wittichii RW1
ZP_01036525 321 DICGMTRAMITDPELAAKARTGRSEKIRACIGCN 354 Roseovarius sp. 217
ZP_00959726 313 DMVSIVRGQIADPHLARKALDGHAQDIRGCISCN 346 Roseovarius nubinhibens ISM

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