1YXY


Conserved Protein Domain Family
NanE

?
cd04729: NanE 
Click on image for an interactive view with Cn3D
N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of related sugars that are found as a component of glycoproteins, gangliosides, and other sialoglycoconjugates.
Statistics
?
PSSM-Id: 240080
Aligned: 31 rows
Threshold Bit Score: 235.933
Created: 11-Jul-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site cavity [active site]
Evidence:
  • Comment:Based on homology to other members of the family

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    # #                              #                     # #         
1YXY_B        8 EKLMEQLKGGIIVSCQALPGeplysetggIMPLMAKAAQEAGAVGIRANSVRDIKEIQAi-tDLPIIGIIKKDYppqEPF 86  Streptococcus py...
Q8FWN5       16 EEIVNRLRGKLIVSCQPVPEspfd--nvaSVVAYARAAEASGASGLRIEGAANVAATAQa-sTLPVIGLIKRDLddsPVR 92  Brucella suis 1330
ZP_01156625   1 MDRLDQLRGGLVVSCQPVGGgamd--rpeIVAAMAAAAVAGGAAGVRIEGIANLRAVRAr-vAVPIIGLVKRDLpdsAVR 77  Oceanicola granu...
AAS62838      5 SNLRHKLQNGLIASCQPVPGsamd--tpeIVAAMACAALAGGAVGLRIEGISNIQAVRRa-tDAPIIGIIKRDLpdsEVR 81  Yersinia pestis ...
Q6A6A0        6 DRIIASMAGGLVVSCQAYPGeplr--hpeTMAQMAAAVEAGGAVAVRAQGLSDVSAVKGr-vSVPVVGIWKEGDe--GIY 80  Propionibacteriu...
BAC90555      1 MNAVIALRGLIVSCQAPEGSplr---dptIIAAMAASACLNGAVAVRIESPEHIRAVRAr-vDVPIVGLWKRPYadsAVY 76  Gloeobacter viol...
ABG50713      4 KHPNLLLPKGLIVSCQAPTNsplh--hpeVIAAMAQASINQGAVGVRIDTPSHIRAVRQr-iTQPIIGLWKQQVpgfEVY 80  Trichodesmium er...
YP_172350     4 QQQLRRLQGGLIVSCQAPADsplh--qpeIIAAIAVAAVQRGAVGIRLDTPEHVRAVRDrlpETPIIGLWKRTFpdsSVY 81  Synechococcus el...
NP_683050     1 MNLATQIRGGLIVSCQAPADspla--apeIIAAMAKAAVLRGAVAVRINTPAHIQAVRQa-vNVPIIGLWKQTLpayPVY 77  Thermosynechococ...
NP_895162     3 LPAFETLRRGLIVSVQAPEGspmr--hpqVIAAMAETSLCNGAVGVRLESPEHIGAVRRrcpNALIIGLWKRSFpdsAVY 80  Prochlorococcus ...
Feature 1                            #                              #                    #   #  
1YXY_B       87 ITATMTEVDQlAALNIAVIAMDCTKRDRHdgldIASFIRQVKEKypnQLLMADISTFDEGLVAHQaGIDFVGTTLSGYTp 166 Streptococcus py...
Q8FWN5       93 ITPFLEDVAAlCDAGAAIVAVDATDRRRPv--pAAELIGEIKRRg--RIAMADISTLAEARNALAaGADIIGTTMSGYTg 168 Brucella suis 1330
ZP_01156625  78 ITPWLDDVRAlADAGADIIAYDATDRPRPe--tTAALVAAIRAAg--ALAMADCATLADGERARDeGAAILGTTLSGYTe 153 Oceanicola granu...
AAS62838     82 ITPWLEDIDAlSAAGADIIAFDVTCRERPv--sVADLYQRARATg--CLTMADASNIDDGLLAHHlGIDFIGTTLSGYTq 157 Yersinia pestis ...
Q6A6A0       81 ITPTLRHARCvSAAGADVVALDGTRRERAdglsLAETIERLKREy-dVVVMADCGSVDDGLFAAEaGADLIGTTLCGYTg 159 Propionibacteriu...
BAC90555     77 ITPTFGDAAAvAQSGADIVAIDATGRPRPggesLAELIGRIHCEl-dRPVLADVATVAEGETAARlGADIVVTTLCGYTe 155 Gloeobacter viol...
ABG50713     81 ITPRLSDAEAiAQVGADIIAIDGTLRRRPdgatLATLINFIHNEl-gKPVMADVDTIEVAKVAVAaGADFIATTLYGYTe 159 Trichodesmium er...
YP_172350    82 ITPRYVEAEAiAAAGADIVALDCTLRPRPdgedFCQIIPRLQQEl-gCAVMADIDTLEAAIAAAKaGADLVGTTLYGYTe 160 Synechococcus el...
NP_683050    78 ITPRFADAVAvAAAGADIIALDATARSRPe--pLQDLIQRIHNEl-gKPVMADIDSLENAAAAVAaGADWVGTTLFGYTe 154 Thermosynechococ...
NP_895162    81 ITPGWEEVQAvWSAGADVVALDATQRHRPggitLDQLVSRVREDl-gAPLMADVDTIENGLRAAElGCSFVGTTLYGYTe 159 Prochlorococcus ...
Feature 1                                    ###                    #             
1YXY_B      167 ysr-qeagPDVALIEALCka---giAVIAEGKIHSPEEAKKINDLGVAGIVVGGAITRPkEIAERF 228 Streptococcus pyogenes
Q8FWN5      169 egp-tpkdPDLDLVAHCSrl---gsFLIAEGRYNSPQQAGEAIRAGADAVVVGSAITRPeHITGWF 230 Brucella suis 1330
ZP_01156625 154 atagrgegVDTGLIRAFRkl---ggFVMAEGRVNTPELAADAMAAGADAVTVGTALTRLeHVTGWF 216 Oceanicola granulosus HTCC2516
AAS62838    158 atv--ptePDLALVTQLAqa---gcRVIAEGRYHSPALAAAAISAGAYAVTVGSAITRIeHICGWF 218 Yersinia pestis biovar Medieva...
Q6A6A0      160 erp-ktdgPDYEVIEALVkkldgdrPVIAEGRIHTPDQARRAMDLGAHAVVVGTAITHPtSITGWF 224 Propionibacterium acnes KPA171202
BAC90555    156 atl-gtplPALDLVGALAgrl--tvPVWCEGGVQSPEQVALAFARGARAVVVGTALTGLdARVRAF 218 Gloeobacter violaceus PCC 7421
ABG50713    160 etk-tespPGFELLKQMVkki--avPAICEGGIASPAMTKKAIDLGAYAVVVGTDITGIdSKVKAY 222 Trichodesmium erythraeum IMS101
YP_172350   161 atq-gqtpPGWDLLETAAqql-pntPVICEGGIASAQAARQACDRGAFAVVVGTAITGIdLQVQAY 224 Synechococcus elongatus PCC 6301
NP_683050   155 tta-htppPSWSLLSQLVehl--svPILSEGGIASPTMAAKALGLGAWAVVVGTDITGIdLKVQQY 217 Thermosynechococcus elongatus ...
NP_895162   160 vta-vkrpPGLCLLGQLRqqldsdvKLICEGGLDSPQIALEALSSGADMVVVGTAITGVdLQVENY 224 Prochlorococcus marinus str. M...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap