1XBV


Conserved Protein Domain Family
KGPDC_HPS

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cd04726: KGPDC_HPS 
Click on image for an interactive view with Cn3D
3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for L-ascorbate utilization in some eubacteria. HPS catalyzes the formation of D-arabino-3-hexulose-6-phosphate from D-ribulose 5-phosphate and formaldehyde in microorganisms that can use formaldehyde as a carbon source. Both catalyze reactions that involve the Mg2+-assisted formation and stabilization of 1,2-enediolate reaction intermediates.
Statistics
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PSSM-Id: 240077
Aligned: 41 rows
Threshold Bit Score: 194.336
Created: 10-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1XBC; E. coli KGPDC with bound Mg2+ and D-ribulose 5-phosphate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #                      #                            # #                  
1XBV_B      4 PMLQVALDNQtmDSAYETTRLIAee-vDIIEVGTILcVGEGVRAVRDLKALyphKIVLADAKIADAGKILSRMCFEaNAD 82  Escherichia coli
AAM01370    1 MLTQVALDLTslPKAIEIAEASVeagiHVLEVGTPLiKAEGSRAIERLAEEfpeRPIVADTKTMDVGALEAELSIKhGAN 80  Methanopyrus kandl...
Q58842    162 PYLQIALDVPtmENLEFLLQTIPnsdhIILEAGTPLiKKFGLEVIEIMREYf-dGFIVADLKTLDTGRVEVRLAFEaTAN 240 Methanocaldococcus...
CAD74170    3 PIVQISLDLTniDEALETAELAMragvDWLEAGTPLiLAEGLHGVRELRAAfpkTPIVADLKTMDGGYLEAEMMANaGAT 82  Rhodopirellula bal...
O27518    173 PYLQVALDLDsmEEMERIINTLPdrerILLEAGTPLvKKFGVGVVRRIRELrrdAFIIADLKTLDVGRIEVKMAADeTAD 252 Methanothermobacte...
BAA31065    1 MILQVALDLTdiEQAISIAEKAArggaHWLEVGTPLiKKEGMRAVELLKRRfpdRKIVADLKTMDTGALEVEMAARhGAD 80  Pyrococcus horikos...
CAJ73826    6 TIIQVALDFVdiHRAIKVASEAIeggaDWLEIGTPLiKSEGMNAIRRLREIfpdTMLVADMKTMDAGRVEMEMAAKaGAN 85  Candidatus Kueneni...
CAF30826    8 PPVQVALDLVdlPRAINIAKEAVlggaTWVEAGTPLiKSEGMNAIRELRKNfptLTIVADMKTMDAGSTEVEMAAKaGAN 87  Methanococcus mari...
NP_069695   4 PILQVALDLLelKRAIEIAGEAIeggaDWLEAGTPLiKSEGMNAIRELKKHyrgHKVLADMKTIDTGAIEVEMAAKsGAD 83  Archaeoglobus fulg...
AAM07844   30 PIIQVALDLLelDRAVEIAKEAVaggaDWIEIGTPLiKSEGMDSIRTMRKAfpdRTILADMKTVDTGAMEVEMAAKaGAD 109 Methanosarcina ace...
Feature 1                                                            #                        
1XBV_B     83 WVTVICCaDINTAKGALDVakefnGDVQIELTGYWTWEQaqq--wrdAGIGQVVYHRSRDAQaag-----------vaWG 149 Escherichia coli
AAM01370   81 LGCVLGAaPEETIRSFVTRahelcAGALVDTIGVNPVDVlsklkgleEFPDYLLLHAAIDEPi---------------TG 145 Methanopyrus kandl...
Q58842    241 AVAISGVaPKSTIIKAIHEcqkcgLISYLDMMNVSEPQKlyd--slkLKPDVVILHRGIDEEt--------------fGI 304 Methanocaldococcus...
CAD74170   83 HVVVMARaHEETIRCVVRAggdfgCQVMGDNMVSEDMVAgakr-ledLGCGFVIHHIGYDERrgiaar-----gdrmpSP 156 Rhodopirellula bal...
O27518    253 AVAISGLgTVESIEKAIHEaqkqgIYSILDMMNVENFVDklr--glkYKPDIVLLHRNVDLEtlraergeelgemsewGN 330 Methanothermobacte...
BAA31065   81 VVSILGVaDDKTIKDALAVarkygVKIMVDLIGVKDKVQrake-leqMGVHYILVHTGIDEQaq------------gkTP 147 Pyrococcus horikos...
CAJ73826   86 IAVVMGNaPGATIRECVLAgknygIKVCADFMDTDAIDErigi-vekCGVDYISIHTAIDDQms------------gkTP 152 Candidatus Kueneni...
CAF30826   88 VILILGVgPDSMIKDAVKAgkkygVLVGTDLIATEDPVKrave-leeMGVDIINIHVGLDQQvl------------nvDP 154 Methanococcus mari...
NP_069695  84 IVIILALsDDDTIAEAIRAarkygCEVMADLINVPDPASrake-veeLGVDYLNVHVGIDQQmk------------glDP 150 Archaeoglobus fulg...
AAM07844  110 VAIILGSaDDSTILDALRSahkygVRVMADLISAPEPIKravd-leaLGVDYINVHVGIDQQmvgk---------dpiSI 179 Methanosarcina ace...
Feature 1                        # #                   ##               
1XBV_B    150 EADITAIkrlsdmgFKVTVTGGLaLEDLPLFkgIPIHVFIAGRSIRDAaspvEAARQF 207 Escherichia coli
AAM01370  146 EELLHKFgvd-rcpARTAVAGGLtPRKIEEL--DGVDLVIVGGYITSSedpvKAAEAV 200 Methanopyrus kandleri AV19
Q58842    305 KKEWKFKe-----nCLLAIAGGVgVENVEELl-KEYQILIVGRAITKSkdpgRVIRMF 356 Methanocaldococcus jannaschii
CAD74170  157 LDQLREVvea--veIPVQAVGGLsIEQAIECpkYGAPLVVLGAPLTIDadafRTADGD 212 Rhodopirellula baltica SH 1
O27518    331 IREIKEIlg---prGLVAVAGGItPSKMQEAldSGADIIVVGRYIIGSrdvrRAAEDF 385 Methanothermobacter thermautotrophicus s...
BAA31065  148 LEDLEKVvka--vkIPVAVAGGLnLETIPKVieLGATIVIVGSAITKSkdpeGVTRKI 203 Pyrococcus horikoshii OT3
CAJ73826  153 FNVLRHIcen--ahTPVAVAGGInSENVVDAinAGAQIVIVGGYISKSenarDAANNI 208 Candidatus Kuenenia stuttgartiensis
CAF30826  155 VELVKRVsen-ckkAKIAAAGGLnSETAVKAyeAGADIIIAGGTLYKSadpeQTARDI 211 Methanococcus maripaludis S2
NP_069695 151 LEVLKDVvds--vsIPVAAAGGLdAERAAACvsMGASIVIVGSNIVKSrnvtESARKV 206 Archaeoglobus fulgidus DSM 4304
AAM07844  180 LMEISEKv-----sVQLAVAGGLdAEGAAKAvkAGARIVIVGGNITRSdnvtEAAKKI 232 Methanosarcina acetivorans C2A

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