Conserved Protein Domain Family
PLA2_plant

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cd04706: PLA2_plant 
PLA2_plant: Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers. This sub-family does not appear to have a conserved active site and metal-binding loop.
Statistics
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PSSM-Id: 153095
View PSSM: cd04706
Aligned: 9 rows
Threshold Bit Score: 132.943
Threshold Setting Gi: 13473404
Created: 3-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative catalytic residues
Evidence:
  • Comment: by similarity, to similar proteins with structure having catalytic activity. The conserved catalytic His residue is well conserved but not the second residue which in catalytically active PLA2s is usually an Asp residue.
  • Citation:PMID 2274788
  • Citation:PMID 1948070
  • Citation:PMID 9276469
  • Citation:PMID 9013608

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                     #                  
NP_179559     25 VARSEECTRTCIAQNCDTL-----SIRYGKYCGIGHSGC-------PGEEPCDDLDACCKIHDHCVEl--------NGMT 84  thale cress
NP_001048622  23 SPPPPPCSRSCAALNCDSV-----GIRYGKYCGVGWSGC-------DGEEPCDDLDACCRDHDHCVDk--------KGLM 82  Japanese rice
ABE90600      33 ISMNETCSRKCESNFCSVPp----LLSYGKYCGINYSGC-------PGETPCDDLDTCCMNHDLCVKak------nYDYL 95  barrel medic
BAD90927      41 ISLEKECSRTCESKFCAVPp----FLRYGKYCGVLYSGC-------PGEQPCDGLDACCMKHDLCIQrk------gNNYL 103 common tobacco
NP_565337     32 ISLTKECSRKCESEFCSVPp----FLRYGKYCGLLYSGC-------PGERPCDGLDSCCMKHDACVQsk------nNDYL 94  thale cress
NP_001051034  49 ASKAGLCSRTCESDHCTTPp----LLRYGKYCGILYSGC-------PGEQPCDELDACCMHHDNCVQa-------kNDYL 110 Japanese rice
ABA94229      42 ADNDEKCSRTCESEHCLGTyaqapLMRYGKYCGVSYTGC-------PGEAPCDALDACCMLHDACVQat------dNDYL 108 Japanese rice
AAM64464     114 PYVSKVPWHTGTRAFLSQL-----FPRYGHYCGPNWSSGkdggsmvWDQRPIDXLDHCCYCHDIGYDthdqaellkADMA 188 thale cress
NP_104971     21 TKVPEAELPKPIRYVMAGPs----PFVFGNYCGPGTRTGd------LSARPVDRLDAVCQTHDACYI---------ARHN 81  Mesorhizobium l...
Feature 1                                         #                                     
NP_179559     85 NISCHKKFQRCVNRLSKAikqsknKKVGFSTKCPYSVVIPTVNQGM------------DIGILFSQLGNDM 143 thale cress
NP_001048622  83 SVKCHEKFKNCMRKVKKA------GKIGFSRKCPYEMAMATMTSGM------------DMAIMLSQLGTQK 135 Japanese rice
ABE90600      96 SQECSQTFIKCLNKFKKSg-----GPTFDGNTCEVDYIIELLSVVM------------EGALLAGSLKQAL 149 barrel medic
BAD90927     104 NLECNQNFLNCVATFTKSg-----APSFKGNTCSVGTVVRVITDVI------------DAAVVAGNIFKKP 157 common tobacco
NP_565337     95 SQECSQKFINCMNNFSQKk-----QPTFKGNKCDADEVIDVISIVM------------EAALIAGKVLKKP 148 thale cress
NP_001051034 111 STACNEELLECLARLREG------SSTFQGNKCMIDEVIDVISLVI------------EAAVVAGRLLHKP 163 Japanese rice
ABA94229     109 NMLCNQSLLDCVAAVRSPaa---rIRTFEGNQCNVTDVADEITSLV------------EAAVFAKRILHRP 164 Japanese rice
AAM64464     189 FLECLESNKRVVTRGDAQ------VAHFYKTMCITGLKSILIPYRSylvkiqygqnllDFGWIVSNLSKRS 253 thale cress
NP_104971     82 HCDCDGALVASARAIRDDrta-prKMRDEAELLIATFAIPVCKVFPqgfm----pprdPAQLSAMKAGATG 147 Mesorhizobium loti MAFF3...

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