Conserved Protein Domain Family
PLA2_group_III_like

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cd04705: PLA2_group_III_like 
PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.
Statistics
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PSSM-Id: 153094
View PSSM: cd04705
Aligned: 9 rows
Threshold Bit Score: 96.4403
Threshold Setting Gi: 47227807
Created: 5-Jan-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                             #          
NP_056530    314 HQKGSKRPSKANTta----------------lqDPMVSprldvaptglqgpqgglkPQGARWVCRSFRRHLdqCEHQIGP 377 human
XP_587287      5 TTLRIERWTKEKTedd---------------tsSWDESr----------------vRGEFKNTDRCCWKHK--CAGHIVR 51  cattle
XP_001108990   5 TTLTIERWTKEKTepk---------------vrSWDESr----------------cCGDCKEPDKCCWKHKq-CTGHIIY 52  rhesus monkey
EAW51126       7 NRLPSWERGHLLAgv----------------asSTDVStf---------------sEGDCKEPDKCCWRHKq-CTGHIIY 54  human
NP_001020929  30 TRLPSWKRGYPASve-----------------sSSDMSsf---------------sEGENKETERCCWKHQq-CPVHIIH 76  Norway rat
BAC32640       1 MSWTAEGRLLYKVgiyell--------hsiqapAPLCSls--------------lhAGVFHGPDLCCREHDq-CPQTISP 57  house mouse
XP_868232      7 NRLPSWERGHLLAgv----------------asSTDAStf--------------ssEGEFKDPDRCCWKHKq-CTGHIIH 55  dog
BAC28367     295 PSKHPQKRGPQQTqarrhstttttpfqtpaissRPDMIprgqpgvph-lgfqdgpkHQSAHRVCRSLRHLDq-CEHQIKP 372 house mouse
CAG08970      13 DRGTIFRAGLSSPvcigg-----------agapRDLVKadvln--------ravdaEKENKETFSLLNGIF--CAKMLTD 71  Tetraodon nigro...
Feature 1                                                       #                                
NP_056530    378 reiefq---------------------------llnsaQEPLFHCNCTRRLARFLRLHsppe---vtnmLWELLGTTCFK 427 human
XP_587287     52 pfspdc--------------------------vhhdvhLHSLSHCDCDSRLKDCSEKTnsssg-dvgptCSRDVDSTCFD 104 cattle
XP_001108990  53 pfasdc--------------------------vchslhLRSVNHCNCNSRLKDCSEDSsssrg--tgptCSHVIESPCFE 104 rhesus monkey
EAW51126      55 pfasdc--------------------------vrhslhLHSVNHCNCNSRLKDSSEDSsssrg--agptCSHVIESPCFE 106 human
NP_001020929  77 sfsdcg---------------------------hhnrcMHAVSHCNCESRCQSYRPISvaif----hhpTHHMYMTDDLN 125 Norway rat
BAC32640      58 lqynyg---------------------------irnfrFHTISHCDCDARCRAYGSTP-----------LAHLRPRTYYN 99  house mouse
XP_868232     56 pftsdy--------------------------ghhnlhLHSVSHCDCDSRLKDCSEKTnssssrdvgpaCSRDEGSTCFN 109 dog
BAC28367     373 qetkfh---------------------------llnsaQMPLFHCDCTRRLARFLRLHsppa---gtdkVWDLLGTTCFK 422 house mouse
CAG08970      72 ggnflyqvsdgveivesvvspsgavvncsvlfgytnfkWHSISHCDCDEKLKACLRRVnd--------tSSRVVGQAFFN 143 Tetraodon nigro...

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