1POC


Conserved Protein Domain Family
PLA2_bee_venom_like

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cd04704: PLA2_bee_venom_like 
Click on image for an interactive view with Cn3D
PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers. Bee venom PLA2 has fewer conserved disulfide bridges than most canonical PLA2s.
Statistics
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PSSM-Id: 153093
View PSSM: cd04704
Aligned: 15 rows
Threshold Bit Score: 137.818
Threshold Setting Gi: 114153140
Created: 5-Jan-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic sitemetal binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Structure:1POC: Bee venom phospholipase A2 bound with a transition state analogue, contacts at 3.5 A.
    View structure with Cn3D
  • Citation:PMID 2274788

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                #            
1POC           1 IIYPGTLWCGHGNKSs-GPNELGrfKHTDACCRTHDMCPDVMSAg--ESKHG-LTNTASHTRLSCDCDDKFYDCLKNSad 76  honeybee
XP_001120293  41 TIVPSTKWCGPGNKAk-NYNDLGfnHITDACCREHDYCPDSIKAl--RRKHN-LWNASLFLRSKCSCDHKFYKCLKNSte 116 honey bee
EAT33614      60 LTLPGTKWCGPGNVAd-DYDDLGkhEDEDKCCREHDHCDNIASG---EEKYG-LKNDDYFTRLHCKCDRDFQQCLKKInt 134 yellow fever mo...
AAF46339     139 LIAPNTRWCGRGNLAngTYNDLGgaSKADKCCRKHDHCKMWIDGm--SNRYD-LFNYRPYTLSHCSCDLRFRTCLKMAgd 215 Drosophila mela...
AAF44746     151 WTMPGTLWCGVGDSAg-NSSELGvfQGPDLCCREHDRCPQNISPl--QYNYG-IRNYRFHTISHCDCDTRFQQCLQNQhd 226 Homo sapiens
NP_572180    102 FIYPGTKWCGPGTAAt-SYDDLGahAREDRCCREHDMCPDVLNVg--ECRRG-LCNRGTFTRSHCDCDARFRRCLQAAnt 177 fruit fly
NP_572855    253 GIIPGTKWCGTGDIAe-TYSDLGseMAMDRCCRQHDLCPIKIRAy--QNKYE-LMNDSLYTKSHCICDDMLFSCLKMTnt 328 fruit fly
ABI52736      28 FIFPDTKWCGAGNVSn-GTGDYGaaRRTDMCCEIHDNATDYILAgksYANHSsLRNPRPHTVTHCKDDMKLFDCLYNDns 106 Argas monolakensis
P59888        31 ETMWGTKWCGSGNEAt-DISELGywSNLDSCCRTHDHCDNIPSG---QTKYG-LTNEGKYTMMNCKCETAFEQCLRNVtg 105 emperor scorpion
Q6PXP0        27 LIVSGTKWCGNNNIAa-NYSDLGf-LEADKCCRDHDHCDHIASG---ETKYG-LENKGLFTILNCDCDEAFDHCLKEIsn 100 Anuroctonus pha...
Feature 1                          #            
1POC          77 --------tiSSYFVGKMYFNLId-TKCYKL 98  honeybee
XP_001120293 117 ---------lIAVGIGKVYFNDIiiPKCFEL 138 honey bee
EAT33614     135 ---------tLSNRLGSFYFAVR--DKCYKK 154 yellow fever mosquito
AAF46339     216 ---------eDANAIGKLFFNVVq-TQCFGL 236 Drosophila melanogaster
AAF44746     227 ---------sISDIVGVAFFNVLe-IPCFVL 247 Homo sapiens
NP_572180    178 ---------eTANTLGAIFYNVVq-VTCFQE 198 fruit fly
NP_572855    329 ---------sASQLMGSIYFNLVq-VPCLDG 349 fruit fly
ABI52736     107 --------tnVSLQFGQAFFDALq-VPCFIE 128 Argas monolakensis
P59888       106 gm-----egpAAGFVRKTYFDLYg-NGCYNV 130 emperor scorpion
Q6PXP0       101 nvttdirqkgGAENVWRFYFQWYn-ANCYRL 130 Anuroctonus phaiodactylus

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