2RIJ


Conserved Protein Domain Family
LbH_THP_succinylT_putative

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cd04649: LbH_THP_succinylT_putative 
Click on image for an interactive view with Cn3D
Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal domain of unknown function and a C-terminal LbH domain with similarity to THP succinyltransferase LbH. THP succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA. It is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The enzyme is trimeric and displays the left-handed parallel alpha-helix (LbH) structural motif encoded by the hexapeptide repeat motif.
Statistics
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PSSM-Id: 100054
View PSSM: cd04649
Aligned: 10 rows
Threshold Bit Score: 199.947
Threshold Setting Gi: 46205004
Created: 10-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative trimerputative CoA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the trimer structures of some members of the superfamily including E. coli Maltose O-acetyltransferase, Chlamydia Trachomatis Lpxd, and E. coli serine acetyltransferase.
  • Comment:Most characterized members of the LbH superfamily form trimeric structures in their active form. However, there are a few members that form different quaternary structures such as Glucose-1-phosphate adenylyltransferase which forms a tetramer. Hence, not all members may form trimers.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               # # # #         #     # #               
2RIJ_A      217 NTRILESSKVRXGASLAa-GTTIXPgaSYVNFNAGTTGACXVEGRISSSAIVGEGSDVGGGASILGVLSGTsgNAISVGK 295 Campylobacter je...
ABF84676    227 NIRLLDSSKTRFGAYLGtgGYTQMPgaSYVNFNAGAMGVCMNEGRISSSVIVGAGTDIGGGASVLGVLSGGnnNPISIGK 306 Helicobacter pyl...
AAG07054    181 GVRIADTARVRLGAYIGe-GTTVMHe-GFVNFNAGTEGPGMIEGRVSAGVFVGKGSDLGGGCSTMGTLSGGgnIVISVGE 258 Pseudomonas aeru...
AAT82386    162 GVRIGDADRVRLGAHLAv-GTTVMHe-GFVNFNAGTLGHSMVEGRISQGVIVGDGTDIGGGASIMGTLSGGgkERVTIGR 239 Propionibacteriu...
ZP_01258209 164 GVRIADTARVRLGAYLGe-GTTVMHe-GFVNYNAGTEGPNMIEGRISSGVFIGKDTDLGGGSSTMGTLSGGneKIISVGE 241 Psychroflexus to...
ZP_00049184   9 GVRIADADRVRLGAHLAa-GTTVMHe-GFVNFNAGTLGTSMVEGRISAGVVVGDGSDVGGGASIMGTLSGGgrEVISVGQ 86  Magnetospirillum...
YP_556055   139 GVRVADADRVRLGAYLAs-GTTVMHe-GFVNFNAGTLGESMVEGRVTPGVVVGKNSDVGAGSSIMGTLSGGgkSKNSIGE 216 Burkholderia xen...
YP_802415   160 NVRISNTNRVRLGAYLCs-GTTIMSe-GYVNFNTFIGKNCMIEGRVSSGVSVFNNTDIGGSSSIMGTLSGGgnNIISIGD 237 Candidatus Carso...
ZP_01872940 184 GVRIGNGAKIRLGAHLGe-GTTVMQa-GFVNFNAGTEGNAMIEGRVSAGVFVSKDSDVGGGASIMGTLSGGgkEVVCIGS 261 Lentisphaera ara...
AAK45496    159 GVRIADADRVRLGAHLAp-GTTVMHe-GFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGgtHVISIGK 236 Mycobacterium tu...
Feature 1         #    ## #       #   # # #                                                     
2RIJ_A      296 ACLLGANSVTGIPLGDNCIVDAGIAVLEGTKFLlkdaeelakl---npyfnfdkeiYKGLELKGLngLHFRQDSISGAXI 372 Campylobacter je...
ABF84676    307 NCLLGANSVTGISLGDGCIVDAGVTILAGSVIEieenefkkllevnsalekhannlYKGKELSGKngVHFRSNSQNGKLI 386 Helicobacter pyl...
AAG07054    259 GCLIGANAGIGIPLGDRNIVEAGLYITAGTKVAlldeqn------------alvkvVKARDLAGQpdLLFRRNSQNGAVE 326 Pseudomonas aeru...
AAT82386    240 GCLLGAEAGIGISLGDNCVVEAGLYVTAGTKVTlpn-----------------gkvVKASELSGAsdILYIRDSTTGIVK 302 Propionibacteriu...
ZP_01258209 242 RCLLGANSGIGISLGNDCTVEAGLYLTAGTKVTlvdn---------------eekiVKALELSGKdgILYYRDSLSGKVC 306 Psychroflexus to...
ZP_00049184  87 RSLLGANAGLGIPLGDDCVVESGLYVTAGTKVTvvgqrda----------sgeplvVKARDLAGRsgILFRRNSLTGGVE 156 Magnetospirillum...
YP_556055   217 RSLLGANAGIGISLGDECIVEAGLYVTAGTKVKlpd-----------------gtiLAARELSGRhgLLFRRNSQTGAVE 279 Burkholderia xen...
YP_802415   238 KCLLGANSGIGISLGNNCIVEAGLYITSGTKIFflfnn--------------kkilIKANKLSFKnnIIFFRNSVNGKVE 303 Candidatus Carso...
ZP_01872940 262 KCLLGANAGTGISLGFGCTVGAGTYITASSKVSlydensnpvnl-ngdlvaegenvVKGLDLSGRdkLLIYQDSVSGKLI 340 Lentisphaera ara...
AAK45496    237 RCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTmpd-----------------snsVKARELSGSsnLLFRRNSVSGAVE 299 Mycobacterium tu...
Feature 1        
2RIJ_A      373 V 373 Campylobacter jejuni
ABF84676    387 A 387 Helicobacter pylori HPAG1
AAG07054    327 C 327 Pseudomonas aeruginosa PAO1
AAT82386    303 A 303 Propionibacterium acnes KPA171202
ZP_01258209 307 A 307 Psychroflexus torquis ATCC 700755
ZP_00049184 157 A 157 Magnetospirillum magnetotacticum MS-1
YP_556055   280 V 280 Burkholderia xenovorans LB400
YP_802415   304 C 304 Candidatus Carsonella ruddii PV
ZP_01872940 341 C 341 Lentisphaera araneosa HTCC2155
AAK45496    300 V 300 Mycobacterium tuberculosis CDC1551

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