Conserved Protein Domain Family
LbH_Dynactin_6

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cd04646: LbH_Dynactin_6 
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p27 is part of the pointed-end subcomplex in dynactin that also includes p25, p26, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain the imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100052
View PSSM: cd04646
Aligned: 15 rows
Threshold Bit Score: 151.324
Threshold Setting Gi: 67609389
Created: 24-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O00399        10 KIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAypdnitpdtedpepkPMIIGTNNV 89  human
AAZ86748       8 KILPKAVVCEESSLRGDITFSSGCVVHPSATVIADAGPIIIGENCIIEEYATVAHRlepgav----wdvnnILSIGTHNV 83  fruit fly
AAW25089      15 HITPGAVVCSECELSGEIIIGANTIIHPRARIIAEAGPIHIGSFNLIEEQVEIVNKip-----------gfTMKIGDHNV 83  Schistosoma jap...
XP_569046     29 TAHATSLICADTDLRGPISVGPNVIIHPRATIYAAAGPIMLGEGCIVEEGCIIVNRkk------------dTMKIGENNH 96  Cryptococcus ne...
EAS06962     254 QKTTATILSQKSEILGNVKFGKGCIIHPNCTILAEGGDIIFGDYNIIEERVSIVNKkskdp------aknkNMFIGSYNL 327 Tetrahymena the...
NP_491116      8 SIASSAIVCVEADIKGEVIIKEGCVVHPFVVFDATKGPIYVGENNIFEEYAVIRNNsd-----------gqPMIIGDWNI 76  nematode
XP_786640     14 KIGAGAVVCVEAELRGDITIGPRTVIHPRARIIAEAGPIVIGESNLVEDQVVIINRkqlgq------egpiTMTIGANNV 87  purple urchin
XP_001629103  12 KIGAGSVVCQEAEIKGEVIIGSKTVVHPKARIIAEAGPIIIGDNNLIEEQVTIINPlqveene-evpperiVMHIGCNNV 90  starlet sea ane...
XP_974941      7 KILPGALVCEESKLRGDITIGAGTIIHPSATILAEAGPIIIGDCCLIEEQAKIIHRlpfdeq---dtektpVLIIGAHNV 83  red flour beetle
XP_001602333 402 KVGVGAIVCEEAILKGDICIGSRTVVHPRASIIAEAGPIIIGEGNIIEEMVTITNRissdp------svtpVQIIGNYNV 475 jewel wasp
O00399        90 FEVGCYSQA-------------------MKMGDNNVIESKAYVGrnVILTSGCIIGACCNLNtf--------eVIPENTV 142 human
AAZ86748      84 FEVGCQVEA-------------------AKIGDKNVFESKCYVGpgVTVSSGCVVGAGIKIHgs--------qRLPENTI 136 fruit fly
AAW25089      84 FEVGAHCYA-------------------LEIGDNNVFEAKCYIGsnMKITHGCVIGAMCSMDsc--------eILPECTV 136 Schistosoma jap...
XP_569046     97 FMVGCRTFYpfdliyldnnligragiesPSIGNNNIFQPKSTASggVIVTDNCIISAGTILLpsptgtdqepeTLPPYTV 176 Cryptococcus ne...
EAS06962     328 FEVGSKIDT-------------------SDIGNMNHFEPRSSVEqdCQIKDKCTIGACVKLPqg--------tIIEDKKI 380 Tetrahymena the...
NP_491116     77 FQVHSKSSA-------------------KYVGSRNVIGVHAVLEdgCSVSDDCSVGAKCTVFsh--------qNLEPSVS 129 nematode
XP_786640     88 FEVGSRCEA-------------------VRVGNNNVVESKAFIGrdTEMSNGCVIGAFCNITsh--------eRLPEHTV 140 purple urchin
XP_001629103  91 FEVGSLCEA-------------------VKIGDNNILEAKSRVGrqTVLSHGCVIGARCEVTsq--------eTIPENTV 143 starlet sea ane...
XP_974941     84 FEVDCHVES-------------------PKIGNCNVFESKCFVGnkVTVTNGCTVGAGCKVTee--------qILKENVI 136 red flour beetle
XP_001602333 476 FEVDSTCEA-------------------SKVGDNNILESKAFVSkeVELTSGCIIGTGCSLTeq--------eTVPENTI 528 jewel wasp
O00399       143 IYGADCLRRvqterp-----qpqtlQLDFLMKILPNYHHLKK 179 human
AAZ86748     137 VYGEQGLQReaidkq-----gsqtlQIDFLRKVLPNYHHLRK 173 fruit fly
AAW25089     137 VYGEECHRRiaterp-----aaqtlQLDFLTKILPNYHHLMK 173 Schistosoma japonicum
XP_569046    177 IYGADSSRRtwdgsghvaemalrskQAEYLREIMPKYVYNDV 218 Cryptococcus neoformans var. neoformans JEC21
EAS06962     381 YYPDKVVKElnfdeqr--fqkhivsMYQALSILIPQNNPVKQ 420 Tetrahymena thermophila SB210
NP_491116    130 VYAATNLSRttktpn-----mtsphQIEFLRKILPSYHHLYG 166 nematode
XP_786640    141 IFGDECRRRlqadkp-----qaqtlQLDFLMKILPNYHHLKK 177 purple urchin
XP_001629103 144 IYGQSCNRRvqaerp-----vpqslQLDFLTKILPNYHHMKK 180 starlet sea anemone
XP_974941    137 IFGEKCQMRegldrp-----glqtlQMETLSKVLPNYHHIRK 173 red flour beetle
XP_001602333 529 IYGNQCQRRemndkp-----ypqigQLDYLMKILPNYHHIYK 565 jewel wasp
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