Conserved Protein Domain Family
TLF
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cd04517: TLF 
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.
Links
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Statistics
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PSSM-Id: 239953
Aligned: 12 rows
Threshold Bit Score: 216.046
Created: 1-Nov-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative DNA interaction surface [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ## #                           ##   # #       # #   # # # #                
Q9W6Z2      9 LDILITNVVCVFRTRcHLNLRKIALeGLNVIYKr--EVSKVLMKLRK-PRITATIWSSGKIICTGATSEEEAKVGARRLA 85  African clawed frog
Q9YGV8      9 LDILITNVVCVFRTRcHLNLRKIALeGANVIYKr--DVGKVLMKLRK-PRITATIWSSGKVICTGATSEEEAKFGARRLA 85  chicken
14530454  263 IDIQIRNVVCNYTLPlHIDLRKLAMnTHNVTYE---REKGVMMKQKRsPGCYIKVYSSGKVYIVGCRSEADCKRAARSIA 339 Caenorhabditis ele...
12653225    9 LDILITNVVCVFRTRcHLNLRKIALeGANVIYKr--DAGKVLMKLRK-PRITATIWSSGKIICTGATSEEEAKFGARRLA 85  human
AAH85661    9 LDIIVTNVVSVFRTRcHLNLRTIGLeGTNVIYKp--EVGKVLMKLRK-PRITASIWSSGKIICTGATSEEEAKLGARRLA 85  zebrafish
4688630    47 FEFQIRNVVCNYTLPlHIDLHRVALnSGNVAFD---RGRGVLLKQKRnPSCYVKIYSSGKIYIVGCRSESECKRAARGVA 123 Brugia malayi
CAB41475  105 LDIVINNVVCSFSVGcHLKLREIALqGSNVEYRr--ENGMVTMKLRH-PYTTASIWSSGRITCTGATSESMAKVAARRYA 181 fruit fly
XP_798726  98 VDIYINNVVCAFGVRcHLNLRRIGQyGSNVEYRr--EYGKVNMRFRR-PSATATIWSSGKITITGNDSEEHAKKNARRCA 174 purple urchin
AAL24503   41 ASVTAFTIMAKFNLRcEIDLRQLAFaLRHAEYNp-rKHSSLTLRLVE-PRATAMVRSSGVVSITGVLDLDELKQSAKKVA 118 Crypthecodinium co...
XP_828065  77 TVPLVVGIIAQAKLGvGVDLRALSCaTRNVEFTprvRCPAATLRLHE-PNAVVQVRTSGLLGIIGSTSVGEARQATELAA 155 Trypanosoma brucei...
13518083  194 AFPVVVAVQAQASIPvGINLAELSCaTRNVEYMpnnRIPPATMRLHE-PTAVVMMHNSGALSIIGAASVSEARQAAELAA 272 Leishmania donovani
XP_768761  16 LSVKVVGYNCRFSLGfNVDMRLLAAsLLTADYNp--RYPTVRVRLTS-PQCCISVSYHGHCTIFGCESVAQAATAAAVFL 92  Giardia lamblia AT...

Feature 1                      #    # #                                        ##    #        
Q9W6Z2     86 RSLQKLGFqv----kFTEFKVVNVLAVCTMPFEIRLNEFTKQNrp----------hASYEPEL--HPAVCYRIKs----- 144 African clawed frog
Q9YGV8     86 RCLQKLGFqv----iFTDFKVVNVLAVCNMPFEIRLPEFTKNNrp----------hASYEPEL--HPAVCYRIKt----- 144 chicken
14530454  340 RHVQRVMGktkervsIRNYRVNNVLATCRLPFGIKIEEVAAKYps----------eSTYEPEL--SVGLVWRSVt----- 402 Caenorhabditis ele...
12653225   86 RSLQKLGFqv----iFTDFKVVNVLAVCNMPFEIRLPEFTKNNrp----------hASYEPEL--HPAVCYRIKs----- 144 human
AAH85661   86 RCLQKMGFkv----rFSDFKVVNVLAVCSMPFQIRLIEFTKNNrp----------iASYEPEL--HPAASYRIKn----- 144 zebrafish
4688630   124 RMVQKTMGkmmdvvrIRNYRVCNVLATCKMPFGVKIEELAQKYpd----------cSQYEPEL--SVGLIWRSTn----- 186 Brugia malayi
CAB41475  182 RCLGKLGFpt----rFLNFRIVNVLGTCSMPWAIKIVNFSERHre----------nASYEPEL--HPGVTYKMRdp---- 241 fruit fly
XP_798726 175 RALQKLGFnv----rLSKYKVVNVLGTCSMPFAIRIRDFSEKHqn----------sASYEPEL--HPAVTYKLYq----- 233 purple urchin
AAL24503  119 RLVQRSGEghe-kvkFAGFTICSILAKASMGFPIRLDQLAAKWrr----------nALYEPEL--YCGCIFRTTr----- 180 Crypthecodinium co...
XP_828065 156 RIIRKALNln---fsSVQFRVRSLMARFDLCHPIRLDELAKHEgv----------fCSYEPDR--FSGCIVRLSgssr-- 218 Trypanosoma brucei...
13518083  273 RIIRKALNln---fsSLKFRVRSIAARFNVCSPIRLDKLAAYQldpamsigvaklqVSYEPER--FNGCVLRLVgkssrg 347 Leishmania donovani
XP_768761  93 KLLNEIEEfvg-larPSPLTVVSITCLTDLGHGIRLDAAAAATisv-------fssAMYQPEImpSLQVVFKIAe----- 159 Giardia lamblia AT...

Feature 1               # # #   #                     
Q9W6Z2    145 ---LRATLQIFSTGSITVTGPDv-KSVASAIEQIYPFVFE 180 African clawed frog
Q9YGV8    145 ---LRATLQIFSTGSITVTGPNv-KAVASAVEQIYPFVFE 180 chicken
14530454  403 ---PKATLRIHTTGSITVTGAQseADVLEVLSKIYPIVLE 439 Caenorhabditis elegans
12653225  145 ---LRATLQIFSTGSITVTGPNv-KAVATAVEQIYPFVFE 180 human
AAH85661  145 ---LRSTVQVFSTGNITVTGPNv-QSVASAVEEIYPLLFE 180 zebrafish
4688630   187 ---PRATLRIHTTGSITVTGAAseSDVMKAVEVIYPIVKE 223 Brugia malayi
CAB41475  242 --dPKATLKIFSTGSVTVTAASv-NHVESAIQHIYPLVFD 278 fruit fly
XP_798726 234 ---PRATLKIFSTGSITVTAPAv-GNISEAIEFIYPLVEA 269 purple urchin
AAL24503  181 ---PKCTYLLTSGGKVMISGFRnmEDVHEAVQRIYPILAE 217 Crypthecodinium cohnii
XP_828065 219 gnqWQVCCTVFVTGKVIVLGARsrEELLDAFYTVLPIIAQ 258 Trypanosoma brucei TREU927
13518083  348 dnqWSVSCSVFVTGKVQLMGARsmDELRFAFNAFVPIIAK 387 Leishmania donovani
XP_768761 160 ---RNICCSVFADGQVTIVGARniFDARDVITKLYEGLFD 196 Giardia lamblia ATCC 50803

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